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Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation.
Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments.
AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types.
Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Drosophila melanogaster aurora A phosphorylates the dynactin (show DCTN1 ELISA Kits) subunit p150(glued (show DCTN1 ELISA Kits)) on sites required for its association with the mitotic spindle.
One of the functions of Aurora A kinase is to direct centrosomal organization such that D-TACC complexed to the MSPS/XMAP215 (show CKAP5 ELISA Kits) microtubule-associated protein (show FAM82A2 ELISA Kits) may be recruited, and thus modulate the behavior of astral microtubules.
Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.
Deletion mapping identifies a central domain of Aurora-A as essential for its centrosomal localization that is augmented by both the amino and the carboxyl terminal ends of the protein.
Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin (show TUBG1 ELISA Kits) to the centrosome and to organize microtubule-nucleating sites via interaction with CNN.
Aurora-A is essential for many crucial events during mitosis and phosphorylation of a series of substrates by Aurora-A at different stages of mitosis may promote diverse critical events in mitosis to maintain chromosome integrity in cells
Zebrafish Aurora-A is critically required for embryonic proliferation during development.
Aurora kinase inhibitor CCT137690 induces necrosis-like death in pancreatic ductal adenocarcinoma cells, via RIPK1, RIPK3, and MLKL signaling.
our data indicate that hnRNP (show HNRNPC ELISA Kits) Q1 is a novel trans-acting factor that binds to Aurora-A mRNA 5'-UTRs and regulates its translation, which increases cell proliferation and contributes to tumorigenesis in colorectal cancer
A central role of Aurora kinase A (AURKA) in promoting Epithelial-to-mesenchymal transition and cancer stem cell phenotypes via ALDH1A1 (show ALDH1A1 ELISA Kits).
Switching Aurora-A kinase on and off at an allosteric site has been documented. (Review)
This is the first report of F31I and V57I polymorphisms in AURKA gene in breast cancer in Iran
High Aurora A kinase expression is associated with triple-negative breast cancer.
Results provide evidence that AURKA is a target for the VHL (show VHL ELISA Kits) E3 ligase ubiquitination.
Results has uncovered a previous unknown positive feedback loop between AURKA and FOXM1 (show FOXM1 ELISA Kits) that promotes breast cancer stem cells (BCSCs) phenotypes and drug resistance. It showed that nuclear AURKA is recruited by FOXM1 (show FOXM1 ELISA Kits) to transactivate the expression of target genes, which also include FOXM1 (show FOXM1 ELISA Kits), whereas AURKA itself is also a downstream transcriptional target of FOXM1 (show FOXM1 ELISA Kits).
AURKA protein over expression is associated with poor prognosis of malignant melanoma patients.
AURKC (show AURKC ELISA Kits) rs758099 TT and (CC + CT) genotypes were positively associated with increased intestinal type gastric cancer (GC)risk, but not with an increased diffuse type GC risk. Based on these results, we can conclude that AURKA rs1047972 and AURKC (show AURKC ELISA Kits) rs758099 polymorphisms could affect the risk of GC development.
CIP2A (show KIAA1524 ELISA Kits) acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 (show PLK1 ELISA Kits) and aurora A during meiotic maturation in mouse oocytes
AURKA stabilizes MYC (show MYC ELISA Kits) to promote tp53 (show TP53 ELISA Kits)-altered liver tumor cell survival.
Bcl2l10 (show BCL2L10 ELISA Kits), Tpx2 (show DAZL ELISA Kits), and Aurka co-localized on the meiotic spindles, and Bcl2l10 (show BCL2L10 ELISA Kits) was present in the same complex with Tpx2 (show DAZL ELISA Kits).
Suppression of neuroendocrine and NEPC development by ICT was associated with dose-dependent inhibitory effects on abnormally elevated IL-6 (show IL6 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) and Aurora kinase A in vitro and in vivo
Our findings demonstrate that prolonged overexpression of Aurora-A can be a driver somatic genetic event in mammary adenocarcinomas associated with deregulated tumor-relevant pathways in the Aurora-A subset of human breast cancer
Data show that aurora-A kinase (AURKA) supports effective spindle formation in zygote.
observations revealed that the alteration of PKB-GSK-3beta axis, Plk-1, and Aurora kinase-A expressions in HSPC compartment due to DNA damage response was associated with the proliferative impairment and apoptosis during aplastic anemia.
Augmented expression of Aurora kinase-A and Polo-like kinase-1 (show PLK1 ELISA Kits) at the lactogenic switch likely mediates the formation of binucleated cells.
Aurora A inhibition causes delocalized clustering of Lck (show LCK ELISA Kits) at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A is required for maintaining Lck (show LCK ELISA Kits) active during T-cell activation.
Aurora A was the most abundant form in oocytes, both at mRNA and protein levels, in bovine oocytes during meiotic maturation.
Aurora kinase A is unlikely to be involved in CPEB1 (show CPEB1 ELISA Kits) activating phosphorylation and cyclin B1 (show CCNB1 ELISA Kits) mRNA polyadenylation during meiotic maturation of porcine oocytes.
Aurora-A may be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during porcine oocyte meiotic maturation, fertilization and early embryonic mitosis
Aurora A stimulates the protein synthesis and promotes the meiotic resumption.
These results suggest a novel relationship between AurA and protein phosphatases during progression throughout the early embryonic cell cycle and shed new light on potential defects caused by AurA overexpression.
MCAK (show KIF2C ELISA Kits) colocalized with NuMA (show NUMA1 ELISA Kits) and XMAP215 (show CKAP5 ELISA Kits) at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing
Plx1 (show PLK1 ELISA Kits) promotes activation of Aurora A, most likely through TPX2.
Aurora-A kinase is required for astral microtubule polymerization and spindle microtubule flux during chromosome segregation.
Data show that Aurora A is a key regulator of microtubule assembly during M phase and therefore of bipolar spindle formation.
binding and elution properties of both the phosphopeptides and unphosphorylated peptides of His6-Aurora A
Results suggest that phosphorylation of maskin (show TACC3 ELISA Kits) by Aurora-A prevents meiosis II proteins from being produced during meiosis I.
The N-terminal non-catalytic domain of Aurora-A can localize to the centrosome in Xenopus egg extracts, while GFP fusions of either the N-terminal or catalytic domains are targeted to the centrosome in Xenopus XL2 cells.
Here we identify G205 in Xenopus Aurora A as a key determinant of both intrinsic activity and regulation by TPX2
The catalytic domain alone of Aurora-A is sufficient to restore spindle bipolarity; additional N-terminal sequences function in mitotic timing.
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.
A-type aurora kinase
, aurora A
, aurora A kinase
, aurora kinase
, Aurora A
, hypothetical protein
, aurora kinase A
, serine/threonine-protein kinase 6
, serine/threonine protein kinase 6
, aurora A kinase protein
, serine/threonine-protein kinase 6-like
, Aurora-A kinase
, IPL1-related kinase
, aurora 2
, aurora-related kinase 1
, aurora/IPL1-like kinase
, aurora/IPL1-related kinase 1
, breast tumor-amplified kinase
, breast-tumor-amplified kinase
, protein phosphatase 1, regulatory subunit 47
, serine/threonine kinase 6
, serine/threonine protein kinase 15
, serine/threonine-protein kinase 15
, serine/threonine-protein kinase aurora-A
, aurora family kinase 1
, ipl1- and aurora-related kinase 1
, serine/threonine-protein kinase Ayk1
, Serine/threonine-protein kinase 6
, aurora kinase A-A
, serine/threonine-protein kinase 6-A
, serine/threonine-protein kinase Eg2
, serine/threonine-protein kinase Eg2-A