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Browse our Aurora A Proteins (AURKA)

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Aurora Kinase A Proteins (AURKA)
On are 25 Aurora Kinase A (AURKA) Proteins from 9 different suppliers available. Additionally we are shipping Aurora A Antibodies (244) and Aurora A Kits (1) and many more products for this protein. A total of 290 Aurora A products are currently listed.
87A7-9/2, AIK, AIRK1, ARK-1, Ark1, AU019385, aur-a, AURA, aurka, aurka-a, Aurora-A, AURORA2, AW539821, Ayk1, BTAK, CG3068, ck10, ck[10], Dmel\\CG3068, Eg2, IAK, IAK1, l(3)87Ac, l(3)ck10, pEg2, PPP1R47, Stk6, STK7, STK15, wu:fb37c10, wu:fc02c02, zgc:100912
list all proteins Gene Name GeneID UniProt
AURKA 6790 O14965
AURKA 20878 P97477
AURKA 261730  

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Aurora A Proteins (AURKA) by Origin

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Top referenced Aurora A Proteins

  1. Human Aurora A Protein expressed in Escherichia coli (E. coli) - ABIN667117 : Chen, Chang, Cheng, Tang, Lin: Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. in The EMBO journal 2002 (PubMed)
    Show all 2 references for ABIN667117

More Proteins for Aurora A Interaction Partners

Fruit Fly (Drosophila melanogaster) Aurora Kinase A (AURKA) interaction partners

  1. Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation.

  2. Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments.

  3. AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types.

  4. Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.

  5. Drosophila melanogaster aurora A phosphorylates the dynactin (show DCTN1 Proteins) subunit p150(glued (show DCTN1 Proteins)) on sites required for its association with the mitotic spindle.

  6. One of the functions of Aurora A kinase is to direct centrosomal organization such that D-TACC complexed to the MSPS/XMAP215 microtubule-associated protein may be recruited, and thus modulate the behavior of astral microtubules.

  7. Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.

  8. Deletion mapping identifies a central domain of Aurora-A as essential for its centrosomal localization that is augmented by both the amino and the carboxyl terminal ends of the protein.

  9. Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin (show TUBG1 Proteins) to the centrosome and to organize microtubule-nucleating sites via interaction with CNN.

  10. Aurora-A is essential for many crucial events during mitosis and phosphorylation of a series of substrates by Aurora-A at different stages of mitosis may promote diverse critical events in mitosis to maintain chromosome integrity in cells

Zebrafish Aurora Kinase A (AURKA) interaction partners

  1. Zebrafish Aurora-A is critically required for embryonic proliferation during development.

Human Aurora Kinase A (AURKA) interaction partners

  1. Aurora A and B inhibition had a significant antitumor effect against TNBC, and this antitumor effect was maximized by the combination of selumetinib with Aurora A and B inhibition.

  2. Aurora kinase A has a role in inducing papillary thyroid cancer lymph node metastasis by promoting cofilin-1 (show CFL1 Proteins) activity

  3. we show for the first time that targeting of the Aurora A kinase in mice using drugs such as Alisertib results in a curative sterilizing therapy that may be useful in treating HPV-driven cancers.

  4. Augmented expression of Aurora kinase-A and Polo-like kinase-1 at the lactogenic switch likely mediates the formation of binucleated cells.

  5. Aurora A kinase inhibitor alisertib 60 mg/m(2) per dose for 7 days is tolerable with a standard irinotecan and temozolomide backbone and has promising response and progression-free survival rates in neuroblastoma (show ARHGEF16 Proteins).

  6. Aurora A inhibition causes delocalized clustering of Lck (show LCK Proteins) at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A is required for maintaining Lck (show LCK Proteins) active during T-cell activation.

  7. Combined treatment with aurora kinase inhibitor SNS (show SCN10A Proteins)-314and quercetin-hyaluronic acid hydrogel results in synergistic cytotoxic effects in papillary and medullary thyroid carcinoma cells.

  8. PC4 (show IFRD1 Proteins) associates with Aurora A and Aurora B (show AURKB Proteins) and undergoes phosphorylation, following which PC4 (show IFRD1 Proteins) activates both Aurora A and B to sustain optimal kinase activity to maintain the phosphorylation gradient for the proper functioning of the mitotic machinery.

  9. Ndel1 (show NDEL1 Proteins) acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.

  10. This present meta-analysis suggests that the Aurora-A expression may be associated with poor prognosis in patients with ovarian cancer.

Mouse (Murine) Aurora Kinase A (AURKA) interaction partners

  1. Augmented expression of Aurora kinase-A and Polo-like kinase-1 at the lactogenic switch likely mediates the formation of binucleated cells.

  2. Aurora A inhibition causes delocalized clustering of Lck (show LCK Proteins) at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A is required for maintaining Lck (show LCK Proteins) active during T-cell activation.

  3. Ndel1 (show NDEL1 Proteins) acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.

  4. The Aurora kinase A and c-Myc expression and histone H3 phosphorylation level were comparatively higher in the cranial tumor than the caudal.

  5. aurora kinase A (AURKA) represents a new therapeutic target in primary myelofibrosis.

  6. A novel function was identified for Aurora-A in controlling the polarization of macrophages and inflammation.

  7. Wdr62 interacts with Aurora A to control mitotic progression, and loss of these interactions leads to mitotic delay and cell death of NPCs, which could be a potential cause of human microcephaly.

  8. Reduced levels of Aurora A protein immediately post-thaw may be associated with the impaired oocyte maturation manifested by the delayed progression through meiosis

  9. Aurka is required for hematopoiesis, but is dispensable for megakaryocyte endomitosis.

  10. Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles.

Cow (Bovine) Aurora Kinase A (AURKA) interaction partners

  1. Aurora A was the most abundant form in oocytes, both at mRNA and protein levels, in bovine oocytes during meiotic maturation.

Pig (Porcine) Aurora Kinase A (AURKA) interaction partners

  1. Aurora kinase A is unlikely to be involved in CPEB1 (show CPEB1 Proteins) activating phosphorylation and cyclin B1 (show CCNB1 Proteins) mRNA polyadenylation during meiotic maturation of porcine oocytes.

  2. Aurora-A may be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during porcine oocyte meiotic maturation, fertilization and early embryonic mitosis

  3. Aurora A stimulates the protein synthesis and promotes the meiotic resumption.

Xenopus laevis Aurora Kinase A (AURKA) interaction partners

  1. These results suggest a novel relationship between AurA and protein phosphatases during progression throughout the early embryonic cell cycle and shed new light on potential defects caused by AurA overexpression.

  2. MCAK (show KIF2C Proteins) colocalized with NuMA and XMAP215 at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing

  3. Plx1 promotes activation of Aurora A, most likely through TPX2.

  4. Aurora-A kinase is required for astral microtubule polymerization and spindle microtubule flux during chromosome segregation.

  5. Data show that Aurora A is a key regulator of microtubule assembly during M phase and therefore of bipolar spindle formation.

  6. binding and elution properties of both the phosphopeptides and unphosphorylated peptides of His6-Aurora A

  7. Results suggest that phosphorylation of maskin (show TACC3 Proteins) by Aurora-A prevents meiosis II proteins from being produced during meiosis I.

  8. The N-terminal non-catalytic domain of Aurora-A can localize to the centrosome in Xenopus egg extracts, while GFP fusions of either the N-terminal or catalytic domains are targeted to the centrosome in Xenopus XL2 cells.

  9. Here we identify G205 in Xenopus Aurora A as a key determinant of both intrinsic activity and regulation by TPX2

  10. The catalytic domain alone of Aurora-A is sufficient to restore spindle bipolarity; additional N-terminal sequences function in mitotic timing.

Aurora A (AURKA) Protein Profile

Protein Summary

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Aurora A (AURKA)

  • aurora (aur)
  • aurora kinase A (aurka)
  • hypothetical protein (Aurora-A)
  • aurora kinase A (AURKA)
  • aurora kinase A (Aurka)
  • 87A7-9/2 protein
  • AIK protein
  • AIRK1 protein
  • ARK-1 protein
  • Ark1 protein
  • AU019385 protein
  • aur-a protein
  • AURA protein
  • aurka protein
  • aurka-a protein
  • Aurora-A protein
  • AURORA2 protein
  • AW539821 protein
  • Ayk1 protein
  • BTAK protein
  • CG3068 protein
  • ck10 protein
  • ck[10] protein
  • Dmel\\CG3068 protein
  • Eg2 protein
  • IAK protein
  • IAK1 protein
  • l(3)87Ac protein
  • l(3)ck10 protein
  • pEg2 protein
  • PPP1R47 protein
  • Stk6 protein
  • STK7 protein
  • STK15 protein
  • wu:fb37c10 protein
  • wu:fc02c02 protein
  • zgc:100912 protein

Protein level used designations for Aurora Kinase A Proteins (AURKA)

A-type aurora kinase , AuroraA , CG3068-PA , aur-PA , aurora A , aurora A kinase , aurora kinase , aurora-A , early-A , fruhe2 , Aurora A , hypothetical protein , aurora kinase A , fb37c10 , fc02c02 , serine/threonine-protein kinase 6 , serine/threonine protein kinase 6 , aurora A kinase protein , serine/threonine-protein kinase 6-like , ARK-1 , Aurora-A kinase , IPL1-related kinase , aurora 2 , aurora-related kinase 1 , aurora/IPL1-like kinase , aurora/IPL1-related kinase 1 , breast tumor-amplified kinase , breast-tumor-amplified kinase , hARK1 , protein phosphatase 1, regulatory subunit 47 , serine/threonine kinase 6 , serine/threonine protein kinase 15 , serine/threonine-protein kinase 15 , serine/threonine-protein kinase aurora-A , aurora family kinase 1 , ipl1- and aurora-related kinase 1 , serine/threonine-protein kinase Ayk1 , ratAurA , Aurora-A , Serine/threonine-protein kinase 6 , aurora kinase A-A , p46Eg265 , pEg2 , serine/threonine-protein kinase 6-A , serine/threonine-protein kinase Eg2 , serine/threonine-protein kinase Eg2-A

41446 Drosophila melanogaster
549324 Xenopus (Silurana) tropicalis
7200473 Phaeodactylum tricornutum CCAP 1055/1
428167 Gallus gallus
445246 Danio rerio
469980 Pan troglodytes
698190 Macaca mulatta
100216431 Ovis aries
100303586 Saccoglossus kowalevskii
100398107 Callithrix jacchus
100459866 Pongo abelii
100469600 Ailuropoda melanoleuca
6790 Homo sapiens
20878 Mus musculus
261730 Rattus norvegicus
504437 Bos taurus
485940 Canis lupus familiaris
574063 Sus scrofa
397925 Xenopus laevis
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