Browse our Aurora Kinase C Proteins (AURKC)

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Aurora Kinase C Proteins (AURKC)
On are 10 Aurora Kinase C (AURKC) Proteins from 5 different suppliers available. Additionally we are shipping Aurora Kinase C Antibodies (125) and many more products for this protein. A total of 145 Aurora Kinase C products are currently listed.
AIE1, AIE2, AIK3, ARK-3, ARK3, AurC, AURKC, aurora-C, IAK3, SPGF5, Stk13
list all proteins Gene Name GeneID UniProt
AURKC 20871  
AURKC 292554  

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Aurora Kinase C Proteins (AURKC) by Origin

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More Proteins for Aurora Kinase C Interaction Partners

Human Aurora Kinase C (AURKC) interaction partners

  1. Aurora-C interactions with members of the Chromosome Passenger Complex (CPC), Survivin (show BIRC5 Proteins) and Inner Centromere Protein (INCENP (show INCENP Proteins)) in reference to known Aurora-B (show AURKB Proteins) interactions to understand the functional significance of Aurora-C overexpression in human cancer cells, is reported.

  2. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2 (show DPY19L2 Proteins).

  3. Homozygous c.144delC mutation in AURKC gene in infertile men with macrozoospermia in the Tunisian population

  4. AURKC mutations are more frequent than Klinefelter syndrome and constitute the leading genetic cause of infertility in North African men.

  5. Low AURKC expression is associated with cancer.

  6. Overexpression of AURKC is associated with breast tumors.

  7. Data indicate that the selective Aurora A (show AURKA Proteins), B, and C inhibitor SAR156497 showed antineoplastic activity in HCT116 cell xenograft model.

  8. This review will describe the functions of each Aurora kinase (show AURKA Proteins) which include Aurora A (AURKA (show AURKA Proteins)), Aurora B (AURKB (show AURKB Proteins)) and Aurora C (AURKC summarize their involvement in leukemia and discuss inhibitor development and efficacy in leukemia clinical trials

  9. Aberrantly expressed Aurora-C in somatic cancer cells may impair spindle checkpoint assembly by displacing the centromeric localization of chromosomal passenger complexes.

  10. Our data indicate that the AURKC c.144delC mutation has a relatively high carrier frequency in the Moroccan population.

Mouse (Murine) Aurora Kinase C (AURKC) interaction partners

  1. These data uncover a role for haspin (show GSG2 Proteins) as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers in oocytes.

  2. these data suggest that mammalian oocytes contain AURKC to efficiently execute meiosis I and ensure high-quality eggs necessary for sexual reproduction.

  3. These findings suggest a model for the presence of AURKC in oocytes: that AURKC compensates for loss of AURKB (show AURKB Proteins) through differences in both message recruitment and protein stability.

  4. Overexpressed Aurora-C (aurkc) is an oncogene (show RAB1A Proteins). Overexpression of Aurora-C induces abnormal cell division resulting in centrosome amplification and multinucleation. Cells overexpressing active Aurora-C induced tumour formation.

  5. Conditional deletion of aurora B in somatic cells that do not express aurora C results in chromosomal misalignment and lack of chromosome segregation.

  6. Aurora-C, but not Aurora-B, plays essential roles in female mouse meiosis.

  7. role in regulating the cleavage furrow-specific vimentin (show VIM Proteins) phosphorylation in the cytokinetic process

  8. INCENP (show INCENP Proteins) recruits Aurora-C (or some other factor(s) recruit INCENP (show INCENP Proteins) and Aurora-C) to meiotic chromosomes, while Aurora-C may either work alone or cooperate with Aurora-B to regulate chromosome segregation during male meiosis

  9. Aurora-B and Aurora-C serve specialized functions in mammalian spermatogenesis.

  10. AURK may be an oocyte histone-H3 (show HIST3H3 Proteins) kinase capable of regulating chromatin remodeling throughout oocyte meiosis.

Cow (Bovine) Aurora Kinase C (AURKC) interaction partners

  1. AURKB (show AURKB Proteins), AURKC, and Thr (show TRH Proteins)-phosphorylated AURKA (show AURKA Proteins) were detected at a contractile ring/midbody during the first polar body extrusion.

Aurora Kinase C (AURKC) Protein Profile

Protein Summary

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Aurora Kinase C (AURKC)

  • aurora kinase C (AURKC)
  • aurora kinase C (LOC100343856)
  • aurora kinase C (Aurkc)
  • aurora kinase C-like (LOC618599)
  • AIE1 protein
  • AIE2 protein
  • AIK3 protein
  • ARK-3 protein
  • ARK3 protein
  • AurC protein
  • AURKC protein
  • aurora-C protein
  • IAK3 protein
  • SPGF5 protein
  • Stk13 protein

Protein level used designations for Aurora Kinase C Proteins (AURKC)

aurora kinase C , ARK-3 , aurora 3 , aurora-related kinase 3 , aurora/IPL1-related kinase 3 , aurora/IPL1/EG2 protein 2 , serine/threonine kinase 13 (aurora/IPL1-like) , serine/threonine-protein kinase 13 , serine/threonine-protein kinase aurora-C , aurora B , aurora/Ipl1/Eg2 protein 1 , serine/threonine kinase 13 (aurora/IPL-like)

740217 Pan troglodytes
100343856 Oryctolagus cuniculus
709801 Macaca mulatta
6795 Homo sapiens
20871 Mus musculus
292554 Rattus norvegicus
618599 Bos taurus
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