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anti-Human CDC25C Antibodies:
anti-Mouse (Murine) CDC25C Antibodies:
anti-Rat (Rattus) CDC25C Antibodies:
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Human Monoclonal CDC25C Primary Antibody for BI, WB - ABIN967552
Peng, Graves, Thoma, Wu, Shaw, Piwnica-Worms: Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. in Science (New York, N.Y.) 1997
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Human Polyclonal CDC25C Primary Antibody for IF (p), IHC (p) - ABIN1387108
Ghate, Chaudhuri, Sarkar, Sajem, Panja, Rout, Mandal: An antioxidant extract of tropical lichen, Parmotrema reticulatum, induces cell cycle arrest and apoptosis in breast carcinoma cell line MCF-7. in PLoS ONE 2013
Show all 2 Pubmed References
Human Monoclonal CDC25C Primary Antibody for IHC, ELISA - ABIN1724739
Busch, Barton, Morgenstern, Götz, Günther, Noll, Montenarh: The G2/M checkpoint phosphatase cdc25C is located within centrosomes. in The international journal of biochemistry & cell biology 2007
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Human Polyclonal CDC25C Primary Antibody for IF (p), IHC (p) - ABIN746993
Yin, Jiang, Peng, Cui, Zhou, He, Zuo, Ouyang, Fan, Fang: The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum. in Oncotarget 2016
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Human CDC25C Primary Antibody for IHC - ABIN965833
Chen, Zhang, Bower, Lu, Leonard, Ding, Castranova, Piwnica-Worms, Shi: Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. in Proceedings of the National Academy of Sciences of the United States of America 2002
Myelodysplastic syndrome -related P95 (show NBN Antibodies) point mutants of SRSF2 (show SRSF2 Antibodies) lead to alternative splicing of CDC25C in a manner that is not dependent on the DNA damage response.
The aim of this review is to shed light on the role of four different phosphatases (PTEN (show PTEN Antibodies), PP2A (show PPP2R4 Antibodies), CDC25 (show RASGRF1 Antibodies) and DUSP1 (show DUSP1 Antibodies)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Data show that TRIB2 (show TRIB2 Antibodies)-mediated degradation of CDC25C is associated with lysine-48-linked CDC25C polyubiquitination driven by the TRIB2 (show TRIB2 Antibodies) kinase-like domain.
the biology of the activation/deactivation of CDC25 (show RASGRF1 Antibodies) by kinases/phosphatases to maintain the level of CDK (show CDK4 Antibodies)-cyclin (show PCNA Antibodies) activities and thus the genomic stability
the knockdown of CDC25C can reduce both the radiotherapy sensitivity and the proliferation activity of EC9706 cells.
results identify CDC25C as a downstream target of the mutated tyrosine kinase (show TXK Antibodies) FLT3 (show FLT3 Antibodies)-ITD affecting cell-cycle regulation in a model of AML (show RUNX1 Antibodies)
Suggest that the p53 (show TP53 Antibodies)-p21 (show CDKN1A Antibodies)-DREAM-CDE/CHR pathway regulates p53 (show TP53 Antibodies)-dependent repression of Survivin (show BIRC5 Antibodies), CDC25C, and PLK1 (show PLK1 Antibodies) in HCT116 cells.
Data indicate that nine compounds were identified with Ki values for CDC25A, -B and -C ranging from 0.01 to 4.4 muM.
These miR (show MLXIP Antibodies)-142-3p functioned as a tumor suppressor by targeting CDC25C.
Cdc25C negatively regulates proapoptotic ASK1 (show MAP3K5 Antibodies) in a cell cycle-dependent manner and may play a role in G2/M checkpoint-mediated apoptosis.
oxidative stress-induced (show SQSTM1 Antibodies) DNA damage of mouse zygotes triggers the cell cycle checkpoint, which results in G2/M cell cycle arrest, and that phospho-Cdc25B (show CDC25B Antibodies) (Ser323), phospho-Cdc25C (Ser216), and phospho-Cdc2 (show CDK1 Antibodies) (Tyr15) participate in activating the G2/M checkpoint.
The role of Cdc25c and Cdc25b (show CDC25B Antibodies) in activating G2/M cell cycle checkpoint in zygote.
an asymmetrical distribution pattern for Cdc25c transcripts in 2-cell embryos.
CDC25A (show CDC25A Antibodies) and CDC25B (show CDC25B Antibodies) but not CDC25C compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells
A single cell cycle genes homology region controls transcription of the cdc25C gene and is able to cooperate with E2F (show E2F1 Antibodies) or Sp1 (show SP1 Antibodies)/3 sites
Cdc25A (show CDC25A Antibodies), or possibly other phosphatases, is able to functionally compensate for the loss of Cdc25B (show CDC25B Antibodies) and Cdc25C in mice
The present study was aimed to investigate the possibility that selenium (Se)-induced oxidative stress mediated alterations in Cdc25c and p21 (show D4S234E Antibodies) may cause modulations in the CDC2 (show CDK1 Antibodies)/Cyclin B1 (show CCNB1 Antibodies) complex responsible for G2/M phase checkpoint in spermatogenesis.
In Lzts1 (show LZTS1 Antibodies)(-/-) mouse embryo fibroblasts (MEFs), Cdc25C degradation was increased during M phase, resulting in decreased Cdk1 (show CDK1 Antibodies) activity.
PP2A:B56delta as a key upstream regulator of Cdk1 (show CDK1 Antibodies) activity upon exit from mitosis
Blocking mitotic entry by adding the catalytic subunit of protein kinase A results in increased wee1 Ser549 phosphorylation and maintenance of cdc25C.
These observations identify PP2A (show PPP2R2B Antibodies)/B56delta as a central checkpoint effector and suggest a mechanism for controlling 14-3-3 (show YWHAQ Antibodies) interactions to promote mitosis.
In Xenopus oocytes, p42 MAPK (show MAPK1 Antibodies) interacts with hypophosphorylated Cdc25 before meiotic induction. During meiotic induction, p42 MAPK (show MAPK1 Antibodies) phosphorylates Cdc25 at three sites, increasing Cdc25's phosphatase activity.
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
cell division cycle 25 homolog C (S. pombe)
, m-phase inducer phosphatase 3-like
, cell division cycle 25 homolog C
, cell division cycle 25C
, Dual specificity phosphatase Cdc25C
, M-phase inducer phosphatase 3
, dual specificity phosphatase Cdc25C
, dual specificity phosphatase CDC25C
, mitosis inducer CDC25
, phosphotyrosine phosphatase
, protein phosphatase 1, regulatory subunit 60
, cell cycle phosphatase CDC25C
, cell division cycle control protein 25C