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Browse our CDK8 Proteins (CDK8)

Full name:
Cyclin-Dependent Kinase 8 Proteins (CDK8)
On www.antibodies-online.com are 12 Cyclin-Dependent Kinase 8 (CDK8) Proteins from 6 different suppliers available. Additionally we are shipping CDK8 Antibodies (90) and CDK8 Kits (15) and many more products for this protein. A total of 125 CDK8 products are currently listed.
Synonyms:
K35, wu:fk95h11
list all proteins Gene Name GeneID UniProt
CDK8 1024 P49336
CDK8 264064 Q8R3L8
CDK8 447409 Q66KH9

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CDK8 Proteins (CDK8) by Origin

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Human Cyclin-Dependent Kinase 8 (CDK8) interaction partners

  1. Data suggest that, during neurogenesis, Mediator complex cyclin (show PCNA Proteins)-dependent kinases (CDK8, CDK19 (show CDK19 Proteins)) interact directly with PRC2 (polycomb (show CBX2 Proteins) repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2 (show EZH2 Proteins)), as well as SUZ12 (suppressor of zeste 12 homolog (show SUZ12 Proteins)).

  2. the expression of CDK8 and its interactive genes has a profound impact on the response to adjuvant therapy in breast cancer in accordance with the role of CDK8 in chemotherapy-induced tumor-supporting paracrine activities--{REVIEW}

  3. Data suggest that MED13, MED12, CDK8 and cyclin C (CycC (show CCNC Proteins)) comprise a four-subunit "kinase" module of the Mediator complex that functions as a major ingress of oncogenic and developmental signaling/gene expression in humans. [REVIEW]

  4. our data provided evidence that CDK-8 played a significant role in colon cancer hepatic metastasis by regulating the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signal pathway

  5. Collectively, our results implicate Ste12 and Tec1 as general and important contributors to the Cdk8, RNAPII-CTD regulatory circuitry as it relates to the maintenance of genome integrity

  6. miR (show MLXIP Proteins)-101 is a potent tumor repressor that directly represses CDK8 expression

  7. Mediator-associated kinases CDK8 and CDK19 (show CDK19 Proteins) restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML (show RUNX1 Proteins)) cells

  8. The Skp2-mH2A1 (show H2AFY Proteins)-CDK8 axis has a critical role in breast cancer development via dysregulation of the G2/M transition, polyploidy, cell growth dysregulation, and loss of tumor suppression.

  9. our results suggest that mTORC1 activation in NAFLD and insulin (show INS Proteins) resistance results in down-regulation of the CDK8-CycC (show CCNC Proteins) complex and elevation of lipogenic protein expression.

  10. Current state of the art confirms that further development of CDK8 inhibitors will translate into targeted therapies in oncology

Zebrafish Cyclin-Dependent Kinase 8 (CDK8) interaction partners

  1. Cloning, sequencing and developmental expression pattern of cyclin-dependent kinase 8.

Mouse (Murine) Cyclin-Dependent Kinase 8 (CDK8) interaction partners

  1. our findings uncover a tumour suppressor function for CDK8 in vivo and suggest that the role of CDK8 activity in driving oncogenesis is context-specific.

  2. The Skp2-mH2A1 (show H2AFY Proteins)-CDK8 axis has a critical role in breast cancer development via dysregulation of the G2/M transition, polyploidy, cell growth dysregulation, and loss of tumor suppression.

  3. our results suggest that mTORC1 activation in NAFLD and insulin (show INS Proteins) resistance results in down-regulation of the CDK8-CycC (show CCNC Proteins) complex and elevation of lipogenic protein expression.

  4. Constitutive phosphorylation of S727 depends on cyclin-dependent kinase 8 (CDK8).

  5. CDK8 is a key regulator of STAT1 (show STAT1 Proteins) and antiviral responses.

  6. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities

  7. This study illustrates a new gene-repressive mechanism of RIP140 (show NRIP1 Proteins) that can affect the transcription machinery by directly interacting with CDK8.

  8. knockdown of CDK8 in cells depleted of mH2A suppresses the proliferative advantage induced by mH2A loss

  9. Results suggest that transcriptional repression of genes critical for early-cell-fate determination underlies the requirement of Cdk8 in embryogenesis.

  10. As receptor-activated Smads form transcriptional complexes, they are phosphorylated at an interdomain linker region by CDK8 and CDK9 (show CDK9 Proteins), which are components of transcriptional mediator and elongation complexes.

Caenorhabditis elegans (C. elegans) Cyclin-Dependent Kinase 8 (CDK8) interaction partners

  1. The C. elegans CDK8 Mediator module regulates axon guidance decisions in the ventral nerve cord and during dorsal axon navigation.

CDK8 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

Alternative names and synonyms associated with CDK8

  • cyclin-dependent kinase 8 (LOC100353845)
  • cyclin-dependent kinase 8 (CDK8)
  • cyclin-dependent kinase 8 (cdk8)
  • cyclin-dependent kinase 8 (Cdk8)
  • cyclin-dependent kinase 8 (LOC100355706)
  • Protein CDK-8 (cdk-8)
  • K35 protein
  • wu:fk95h11 protein

Protein level used designations for CDK8

cyclin-dependent kinase 8 , CDK8 protein kinase , cell division protein kinase 8 , mediator complex subunit CDK8 , mediator of RNA polymerase II transcription subunit CDK8 , protein kinase K35 , mediator complex subunit cdk8 , mediator of RNA polymerase II transcription subunit cdk8

GENE ID SPECIES
100353845 Oryctolagus cuniculus
1024 Homo sapiens
373868 Danio rerio
447409 Xenopus laevis
428080 Gallus gallus
486035 Canis lupus familiaris
264064 Mus musculus
100524102 Sus scrofa
100355706 Oryctolagus cuniculus
172677 Caenorhabditis elegans
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