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anti-Human CDKN1C Antibodies:
anti-Rat (Rattus) CDKN1C Antibodies:
anti-Mouse (Murine) CDKN1C Antibodies:
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Human Monoclonal CDKN1C Primary Antibody for WB - ABIN967507
Graña, Reddy: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). in Oncogene 1995
Show all 3 Pubmed References
Human Polyclonal CDKN1C Primary Antibody for ICC, IF - ABIN4343023
Mochizuki, Tamai, Imai, Sugawara, Ogama, Nakamura, Matsuura, Yamaguchi, Satoh, Sato, Motohashi, Sugamura, Tanaka: CD271 regulates the proliferation and motility of hypopharyngeal cancer cells. in Scientific reports 2016
Data provide evidence that SLC22A18 and/or CDKN1C are tumor modifier genes involved in the tumorigenesis of SDHD (show SDHD Antibodies)-mutated paraganglioma.
The differences in p18(INK4c (show CDKN2C Antibodies))and p57(Kip2)activities in chronic myeloid leukemia (show BCL11A Antibodies) and normal stem cells suggest a different cell cycle regulation.
The data has been provided on fetal growth patterns and on the molecular subtypes of Beckwith-Wiedemann syndrome, including gain or loss of DNA methylation (show HELLS Antibodies), 11p15.5 paternal uniparental disomy, and CDKN1C mutation.
Analysis of the chromatin status of Cdkn1c promoter and KvDMR1 in unresponsive compared to responsive cell types showed that their differential responsiveness to the MyoD (show MYOD1 Antibodies)-dependent induction of the gene does not involve just their methylation status but, rather, the differential H3 lysine 9 dimethylation at KvDMR1.
CDKN1C protein expression in the BM of newly diagnosed, treatment-naive MDS (show PAFAH1B1 Antibodies) and secondary AML (show RUNX1 Antibodies) patients was identified as a prognostic factor for poor survival in patients treated with antiproliferative chemotherapy.
Low P57KIP2 Expression is associated with Hydatidiform Moles.
These results indicate that the inhibitory effect of rapamycin may be due mainly to increased p14 (show S100A9 Antibodies), p15 (show CDKN2B Antibodies), and p57 expression via promoter demethylation and decreased mTOR (show FRAP1 Antibodies) and p70S6K (show RPS6KB1 Antibodies) expression in ALL cell lines.
Jab1/Csn5 (show COPS5 Antibodies) expression with concurrent low p57 expression associated with poor overall survival in hepatocellular carcinoma
We identified a novel variant (rs7164338) on chromosome 15q25.1 in the CIB2 associated with lower pulse wave velocity.
CIB2 (Calcium and Integrin Binding Protein (show CIB1 Antibodies) 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family
Myod (show MYOD1 Antibodies) in turn up-regulates cdkn1c, thereby providing a positive feedback loop that switches myogenic cells to terminal differentiation
p57Kip2 is both necessary and sufficient to mediate Shh (show SHH Antibodies)-induced cell-cycle exit in the deveoping zebrafish retina.
during late embryogenesis, neural cells that have low but functional levels of Cdkn1c, regulated by Notch (show NOTCH1 Antibodies) activity, are specified for oligodendrocyte fate
Methylation of KvDMR1 involved in regulating the imprinting of CDKN1C
proper expression levels of the imprinted genes CDKN1C and PHLDA2 (show PHLDA2 Antibodies) are critical for embryo development
This is the first report linking elevated Cdkn1c to altered behaviour in mice. Importantly, the findings from our study may have relevance for Silver Russell Syndrome and highlight a potentially underreported aspect of this disorder.
Dnmt3a (show DNMT3A Antibodies)-cKO muscles exhibit fewer Pax7 (show PAX7 Antibodies)+ SCs (show TWIST1 Antibodies), which show increased expression of p57Kip2 protein
indicate that the effects of insulin-like growth factor 2 (IGF2 (show IGF2 Antibodies)) are mediated by direct upregulation of the cyclin-dependent kinase inhibitor p57 (p57).
Data show that transforming growth factor beta (TGFbeta (show TGFB1 Antibodies))-induced changes in Gata2 transcription factor (show GATA2 Antibodies) and cyclin-dependent kinase inhibitor 1C (P57) expression in hematopoietic progenitors are conveyed through Smad (show SMAD1 Antibodies) signaling via Smad4 protein (show SMAD4 Antibodies).
This study reveals a key requirement for Cdkn1c in the early development of the brown adipose lineages.
Lhx6 (show LHX6 Antibodies) and Lhx8 (show LHX8 Antibodies) promote palate development through negative regulation of a cell cycle inhibitor (show CDKN2A Antibodies) gene, p57Kip2
hepatoblasts in p57(Kip2)-/- mice were highly proliferative and had deficient maturation compared with those in wild-type (WT) mice.
Data indicate that cyclin-dependent kinase inhibitor 1C (P57 was post-transcriptionally regulated by microRNA miR (show MLXIP Antibodies)-221 in embryonic stem (ES) cells.
Data show that disruption of potassium voltage-gated channel, KQT-like subfamily Q, member1 (KCNQ1 (show KCNQ1 Antibodies)) results in increased expression of cyclin-dependent kinase inhibitor 1C (Cdkn1c) only when the mutation is on the paternal allele.
Results support a model where ARX regulates the expansion of cortical progenitor cells through repression of Cdkn1c
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
, DNA-dependent protein kinase catalytic subunit-interacting protein 2
, KIP 2
, Usher syndrome 1J (autosomal recessive)
, calcium and integrin-binding family member 2
, cyclin-dependent kinase inhibitor 1C, p57
, cyclin-dependent kinase inhibitor p57
, p57KIP2 A3sh
, cyclin-dependent kinase inhibitor 1C (p57, Kip2)
, cyclin-dependent kinase inhibitor 1C