Browse our CDKN2C Proteins (CDKN2C)

Full name:
Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) Proteins (CDKN2C)
On are 11 Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C) Proteins from 6 different suppliers available. Additionally we are shipping CDKN2C Antibodies (100) and CDKN2C Kits (6) and many more products for this protein. A total of 123 CDKN2C products are currently listed.
C77269, CDKN2C, INK4c, INK4d, p18, p18-INK4C, p18INK4c
list all proteins Gene Name GeneID UniProt
CDKN2C 1031 P42773
CDKN2C 12580 Q60772
Rat CDKN2C CDKN2C 54238  

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CDKN2C Proteins (CDKN2C) by Origin

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Top referenced CDKN2C Proteins

  1. Human CDKN2C Protein expressed in Escherichia coli (E. coli) - ABIN667655 : Blais, Labrie, Pouliot, Lachance, Labrie: Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. in Biochemical and biophysical research communications 1998 (PubMed)
    Show all 2 references for 667655

More Proteins for CDKN2C Interaction Partners

Human Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C) interaction partners

  1. CDKN2C gene deletion is associated with plasma cell post-transplantation lymphoproliferative disorders.

  2. The differences in p18(INK4c)and p57(Kip2 (show CDKN1C Proteins))activities in chronic myeloid leukemia (show BCL11A Proteins) and normal stem cells suggest a different cell cycle regulation.

  3. Our study suggests that p18 is a limiting factor for the noncanonical HSC (show FUT1 Proteins) differentiation path in lymphoid lineages.

  4. CDKN2C inactivation contributes to the leukemogenesis in acute promyelocytic leukemia (show PML Proteins).

  5. DNA methyltransferase 3A (show DNMT3A Proteins) promotes cell proliferation by silencing CDK (show CDK4 Proteins) inhibitor p18INK4C in gastric carcinogenesis

  6. Data suggest that cell cycle-dependent kinase inhibitors CDKN2C/p18 and CDKN1A/p21 (show CDKN1A Proteins) facilitate cell cycle entry/cell proliferation of quiescent adult human pancreatic beta cells in primary culture (from tissues obtained from organ donors).

  7. this studydemonstrated abundant levels of the critical negative cell-cycle regulators, p27(Kip1 (show CDKN1B Proteins)), its phosphorylated form, p-p27 (show PAK2 Proteins)(S10 (show L1CAM Proteins)), p18Ink4c, and GSK-3, in beta-cells of both adult human and mouse pancreatic islets, which contribute to maintenance of beta-cell quiescence.

  8. in 85 sporadic parathyroid adenomas, study identified alterations in 5 adenomas: 2 contained heterozygous changes in CDKN1A, 1 germline and 1 of undetermined germline status; 1 had a CDKN2B (show CDKN2B Proteins) germline alteration, accompanied by loss of the normal allele in the tumor (LOH); 2 had variants of CDKN2C, 1 somatic and 1 germline with LOH

  9. Mutations in CDKN2C is associated with sporadic parathyroid adenoma.

  10. Analysis of B1a lymphocyte phenotypes of p18-deficient C57BL/6 mice finds that p18 is a key regulator of the size of the B1a cell pool.

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C) interaction partners

  1. CD4 (show CD4 Proteins)+ T cells from mice genetically deficient for p18ink4c divide more rapidly than wild-type cells in response to antigenic, costimulatory and growth factor signals.

  2. p18 represents a potent and specific target for enhancing the self-renewal property of HSC (show FUT1 Proteins), as demonstrated the effect of inhibitors

  3. p18 may play protective roles and may be associated with or partially account for the cytoprotective effects of HO-1 (show HMOX1 Proteins) in cisplatin-induced acute kidney injury.

  4. Cdk4 (show CDK4 Proteins) and Cdk6 (show CDK6 Proteins) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (show CDK6 Proteins) in sequestering INK4 proteins away from Cdk4 (show CDK4 Proteins).

  5. Gata3 (show GATA3 Proteins)/Ruvbl2 (show RUVBL2 Proteins) complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.

  6. deletion of P18 results in a deacreased proliferation of hematopoietic progenitor cells (HPCs) suggesting a positive role for P18 on HPCs in vivo

  7. A p18 -74 C/T mutation is the leading causal variant for the cell expansion that characterizes NZB and NZM2410 lupus-prone mouse strains.

  8. This study demonstrated the predominant expression MEN1 (show MEN1 Proteins)-related genes, particularly MLL (show MLL Proteins) and p27 (show CDKN1B Proteins), in the endocrine organs, and a tissue-specific haploinsuffiency of MLL (show MLL Proteins) may lead to a decrease in levels of p27 (show CDKN1B Proteins) and p18 mRNAs in endocrine organs.

  9. Cdkn2c plays a critical role in B1a cell self-renewal and its impaired expression leads to an accumulation of these cells with high autoreactive potential.

  10. define the first physiologic function for Noxa (show PMAIP1 Proteins) and suggest that by repressing Noxa (show PMAIP1 Proteins), induction of G arrest by p18INK4c bypasses a homeostatic cell-cycle checkpoint in intermediate plasma cells (iPCs) for PC differentiation

CDKN2C Protein Profile

Protein Summary

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

Alternative names and synonyms associated with CDKN2C

  • cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (CDKN2C)
  • cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (cdkn2c)
  • cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (Cdkn2c)
  • C77269 protein
  • CDKN2C protein
  • INK4c protein
  • INK4d protein
  • p18 protein
  • p18-INK4C protein
  • p18INK4c protein

Protein level used designations for CDKN2C

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) , cyclin-dependent kinase 4 inhibitor C , CDK6 inhibitor p18 , cyclin-dependent inhibitor , cyclin-dependent kinase 6 inhibitor p18 , p18-INK6 , cyclin-dependent kinase 6 inhibitor , p18-INK4c

429104 Gallus gallus
469319 Pan troglodytes
505691 Bos taurus
711877 Macaca mulatta
100144705 Xenopus (Silurana) tropicalis
1031 Homo sapiens
12580 Mus musculus
475359 Canis lupus familiaris
54238 Rattus norvegicus
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