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p19 may play an important role in the ototoxic effects of cisplatin and is probably involved in the pathogenesis of hearing loss.
MiR (show MLXIP Proteins)-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D and MAP3K1 (show MAP3K1 Proteins) expression.
Data indicate that upon oxidative DNA damage, cyclin-dependent kinase (show CDK1 Proteins) inhibitor p19INK4d strongly binds to and relaxes chromatin.
CDKN2D repression by PML (show PML Proteins)/RARalpha (show RARA Proteins) disrupts both cell proliferation and differentiation in the pathogenesis of acute promyelocytic leukemia (show PML Proteins).
p19-INK4d inhibits neuroblastoma (show ARHGEF16 Proteins) cell growth, induces differentiation and is hypermethylated and downregulated in MYCN (show MYCN Proteins)-amplified neuroblastomas.
CDKN2D-WDFY2 (show ZFYVE22 Proteins) fusion could be an important molecular signature for understanding and classifying sub-lineages among heterogeneous high-grade serous ovarian carcinomas.
Mutations in CDKN2D is associated with sporadic parathyroid adenoma.
P19(INK4d) expression is a poor prognostic factor in ovarian cancer patients.
PTB (show PTBP1 Proteins) plays as a negative regulator in H1299 cell proliferation at least by inducing p19(Ink4d) expression at transcriptional and post-transcriptional levels.
Up-regulation of CDKN2D during in-vitro passages of human amniotic fluid-derived mesenchymal stromal cells may indicate the begging of early senescence process in a p53 (show TP53 Proteins)-independent mechanism.
Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase (show CDK1 Proteins) inhibitor p19Ink4d.
p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging
Cdk4 (show CDK4 Proteins) and Cdk6 (show CDK6 Proteins) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (show CDK6 Proteins) in sequestering INK4 proteins away from Cdk4 (show CDK4 Proteins).
Deletion of p19(Ink4d) (p19), a cyclin-dependent kinase (show CDK1 Proteins) CDK (show CDK4 Proteins) inhibitor gene, in mice results in spontaneous development of tumors in multiple organs and tissues.
We propose that p19INK4d participates in the cellular mechanisms that trigger senescence by contributing to chromatin compaction
CDK5 (show CDK5 Proteins)-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions.
an asymmetrical distribution pattern for Cdkn2d transcripts in 2-cell embryos.
Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner.
DeltaNp63alpha has oncogenic activity and its overexpression in human squamous cell carcinomas contributes to the malignant phenotype, and implicate its ability to regulate p16(ink4a)/p19(arf) in the process.
A significant proportion of immortalised cell cultures apparently had neither a p53 mutation nor loss of p19/ARF.
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
, cyclin-dependent kinase 4 inhibitor D
, Cyclin-dependent kinase 4 inhibitor D
, CDK inhibitor p19INK4d
, cell cycle inhibitor, Nur77 associating protein
, cyclin-dependent kinase 4 inhibitor D p19
, inhibitor of cyclin-dependent kinase 4d