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Data revealed that MLF interacts with CSN3 in vivo and that the PCI (show SERPINA5 ELISA Kits) domain of the dCSN3 protein is sufficient for this to occur, possibly functioning as a structural scaffold for assembly of the COP9 (show COPS8 ELISA Kits) signalosome complex.
CSN3 (show CSN3 ELISA Kits) and CSN5 (show COPS5 ELISA Kits) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (show CCNB1 ELISA Kits) and Securin (show PTTG1 ELISA Kits) via APC (show APC ELISA Kits)/C.
Cops3 encodes the third subunit of the COP9 (show COPS8 ELISA Kits) signalosome, which controls a wide vasriety of molecules of different functions.
CSN3 functions in a distinct protein complex that is required for proper auxin signaling.
this study demonstrates Csn3 (show CSN3 ELISA Kits) as an oncogene (show RAB1A ELISA Kits) that regulates the tumorigenesis process in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) cells.
of the COPS3 gene might have important roles in metastasis of osteosarcoma cells.
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila COP9 signalosome homolog 3
, COP9 signalosome complex subunit 3
, COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
, COP9 constitutive photomorphogenic homolog subunit 3
, COP9 signalosome complex subunit 3-like
, COP9 (constitutive photomorphogenic), subunit 3
, COP9 complex S3
, JAB1-containing signalosome subunit 3
, signalosome subunit 3
, COP9 complex subunit 3
, COP9 (constitutive photomorphogenic) homolog, subunit 3