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COP9 (show COPS8 Proteins) signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.
we link the CSN to the degradation of Cyclin E, which promotes the G1-S transition in the cell cycle and then is rapidly degraded by the ubiquitin-proteasome pathway
the CSN4 subunit of the COP9 (show COPS8 Proteins) signalosome co-occupies retinoblastoma target gene promoters with Rbf2
CSN4 silencing decreases CSN5 (show COPS5 Proteins) protein levels and suggest that the CSN4 effects on sGCA1 and p53 (show TP53 Proteins) proteins are mediated by CSN5 (show COPS5 Proteins).
Identified is a novel-binding partner of torsin A (show TOR1A Proteins), the subunit 4 (CSN4) of CSN signalosome.
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene.
, COP9 signalosome subunit 4
, drosophila COP9 signalosome homolog 4
, COP9 signalosome complex subunit 4
, JAB1-containing signalosome subunit 4
, COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
, COP9 (constitutive photomorphogenic), subunit 4
, COP9 complex S4
, signalosome subunit 4
, COP9 constitutive photomorphogenic-like protein subunit 4
, COP9 constitutive photomorphogenic homolog subunit 4
, COP9 (constitutive photomorphogenic) homolog, subunit 4