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Browse our anti-COPS5 (COPS5) Antibodies

Full name:
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) Antibodies (COPS5)
On www.antibodies-online.com are 109 COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) Antibodies from 24 different suppliers available. Additionally we are shipping COPS5 Proteins (7) and COPS5 Kits (3) and many more products for this protein. A total of 126 COPS5 products are currently listed.
Synonyms:
AI303502, BcDNA.LD14392, BcDNA:LD14392, CG14884, CH5, COPS5, CSN-5, CSN5, dch5, Dmel\\CG14884, Jab1, jab1/csn5, JadBp, l(3)89Cf, l(3)L4032, l(3)M203, MGC76063, MOV-34, Mov34, quo, SGN5, zgc:73130
list all antibodies Gene Name GeneID UniProt
COPS5 26754 O35864
COPS5 10987 Q92905
COPS5 312916  

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Most Popular Reactivities for anti-COPS5 (COPS5) Antibodies

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anti-Mouse (Murine) COPS5 Antibodies:

anti-Human COPS5 Antibodies:

anti-Rat (Rattus) COPS5 Antibodies:

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Top referenced anti-COPS5 Antibodies

  1. Human Monoclonal COPS5 Primary Antibody for IF, WB - ABIN968614 : Chauchereau, Georgiakaki, Perrin-Wolff, Milgrom, Loosfelt: JAB1 interacts with both the progesterone receptor and SRC-1. in The Journal of biological chemistry 2000 (PubMed)
    Show all 6 references for ABIN968614

  2. Chicken Polyclonal COPS5 Primary Antibody for WB - ABIN2777332 : Zhang, Chen, Su, Yang, Lee: Roles for CSN5 in control of p53/MDM2 activities. in Journal of cellular biochemistry 2008 (PubMed)

  3. Human Polyclonal COPS5 Primary Antibody for IHC, WB - ABIN2777618 : Oono, Yoneda, Manabe, Yamagishi, Matsuda, Hitomi, Miyata, Mizuno, Imaizumi, Katayama, Tohyama: JAB1 participates in unfolded protein responses by association and dissociation with IRE1. in Neurochemistry international 2004 (PubMed)

  4. Human Polyclonal COPS5 Primary Antibody for ELISA, WB - ABIN1534047 : Claret, Hibi, Dhut, Toda, Karin: A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. in Nature 1996 (PubMed)

More Antibodies against COPS5 Interaction Partners

Fruit Fly (Drosophila melanogaster) COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) interaction partners

  1. COP9 (show COPS8 Antibodies) signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.

  2. during oogenesis CSN5/JAB1, one subunit of the CSN, is required for meiotic progression and for establishment of both the AP and DV axes of the Drosophila oocyte

  3. we link the CSN to the degradation of Cyclin E, which promotes the G1-S transition in the cell cycle and then is rapidly degraded by the ubiquitin-proteasome pathway

  4. results presented here indicate that CSN5 is a negative regulator of Dorsal subcellular localization, and of hemocyte proliferation and differentiation

Mouse (Murine) COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) interaction partners

  1. CSN3 (show CSN3 Antibodies) and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 (show CCNB1 Antibodies) and Securin (show PTTG1 Antibodies) via APC (show APC Antibodies)/C.

  2. COPS5 overexpression reduced spinophilin (show PPP1R9B Antibodies) in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills

  3. Jab1 is an essential regulator of early embryonic limb development.

  4. Lack of COPS5 in regenerating livers causes substantial replicative stress which triggers a cyclin-dependent kinase (show CDK1 Antibodies) inhibitor(CDKN)2A genetic program leading to cell cycle arrest, polyploidy, and apoptosis.

  5. Jab1 may transduce laminin211 signals to regulate Schwann cell number and differentiation during axonal sorting.

  6. Study demonstrates that Jab1 represses chondrocyte hypertrophy in vivo, likely in part by downregulating BMP signaling and Runx2 (show RUNX2 Antibodies) activity.

  7. Data indicate that in Cul4b (show CUL4B Antibodies)-deficient embryonic fibroblasts showed Jab1 accumulation.

  8. CSN5 functions through CDK2 (show CDK2 Antibodies) to control premature senescence in a novel way, depending on cyclin E (show CCNE1 Antibodies) in the cytoplasm.

  9. It was shown that disruption of CSN5 prevented the formation of tumors by p53 (show TP53 Antibodies)-null cells that were transformed with an active form of Ras in subcutaneously injected mice. Depletion of CSN5 suppressed cell proliferation, and induced premature senescence.

  10. These findings identify JAB1 as an important factor in checkpoint control during early B cell development, as well as in fate decisions in mature Ag-primed B cells.

Pig (Porcine) COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) interaction partners

  1. The porcine JAB1 gene was cloned and characterized.

Human COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) interaction partners

  1. Copine3 binding to ErbB2 (show ERBB2 Antibodies) increases when Jab1 is overexpressed in SKBr3 breast cancer cells. PI3 kinase (show PIK3CA Antibodies) and AKT (show AKT1 Antibodies) were also activated by Jab1 overexpression.Copine3 and Jab1 binding regulates the ErbB2 (show ERBB2 Antibodies) signaling pathway.

  2. The reverse correlation of Jab1 and Smad4 (show SMAD4 Antibodies) in PANC-1 cells may be involved in the Pathogenesis of prostate cancer. Jab1 can cause degradation of Smad4 (show SMAD4 Antibodies) via TGF-beta (show TGFB1 Antibodies) signal pathway.

  3. Jab1/Csn5 expression with concurrent low p57 (show CDKN1C Antibodies) expression associated with poor overall survival in hepatocellular carcinoma

  4. LPA (show APOA Antibodies) stimulated interaction of CSN5 with HIF1alpha (show HIF1A Antibodies) and MIF (show AMH Antibodies). Depletion of CSN5 mitigated the association between HIF1alpha (show HIF1A Antibodies) and MIF (show AMH Antibodies). We suggest HIF1alpha (show HIF1A Antibodies), MIF (show AMH Antibodies), and CSN5 form a ternary complex that is necessary to prevent degradation of HIF1alpha (show HIF1A Antibodies) under aerobic conditions

  5. Integrin beta-1 (show ITGB1 Antibodies), transforming growth factorbeta1 and nuclear factorkappaB pathways are modified by CSN5 in hepatocllular carcinoma cells.

  6. Down regulation of CSN5 may inhibit invasion and arrests cell cycle progression in colorectal cancer via PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies)/NF-kappaB (show NFKB1 Antibodies) signal pathway.

  7. Knockdown of CSN5 could inhibit proliferation and promote apoptosis of gastric cancer cells. Additionally, suppression of CSN5 expression contributed to the increased expression levels of p53 (show TP53 Antibodies) and Bax (show BAX Antibodies).

  8. Jab1 expression was increased in endometriosis.

  9. CSN5 promotes SIAH-1 degradation in HCT116 and SW480 cells and that this is associated with its deNEDDylase activity.

  10. CSN4 (show COPS4 Antibodies) silencing decreases CSN5 protein levels and suggest that the CSN4 (show COPS4 Antibodies) effects on sGCA1 and p53 (show TP53 Antibodies) proteins are mediated by CSN5.

Caenorhabditis elegans (C. elegans) COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) interaction partners

  1. The work described here supports a previously unknown role for the CSN/COP9 (show COPS8 Antibodies) signalosome in chromosome behavior during meiotic prophase I.

  2. Data show that CSN-5 functions in muscle cells to regulate UNC-98 and -96, two M-line proteins.

  3. KGB-1 and CSN-5 regulate GLH-1 levels, with GLH-1 targeted for proteosomal degradation by KGB-1 and stabilized by CSN-5.

COPS5 Antigen Profile

Antigen Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.

Alternative names and synonyms associated with COPS5

  • COP9 complex homolog subunit 5 (CSN5) antibody
  • COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) (COPS5) antibody
  • COP9 constitutive photomorphogenic homolog subunit 5 (cops5) antibody
  • COP9 signalosome complex subunit 5 (CpipJ_CPIJ012314) antibody
  • COP9 signalosome complex subunit 5 (Bm1_46585) antibody
  • COP9 signalosome complex subunit 5 (VDBG_06932) antibody
  • COP9 signalosome complex subunit 5 (LOAG_01443) antibody
  • COP9 signalosome complex subunit 5 (csn5) antibody
  • COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) (Cops5) antibody
  • COP9 signalosome subunit 5 (COPS5) antibody
  • COP9 signalosome subunit 5 (Cops5) antibody
  • COP9 signalosome subunit 5 (cops5) antibody
  • Protein CSN-5 (csn-5) antibody
  • AI303502 antibody
  • BcDNA.LD14392 antibody
  • BcDNA:LD14392 antibody
  • CG14884 antibody
  • CH5 antibody
  • COPS5 antibody
  • CSN-5 antibody
  • CSN5 antibody
  • dch5 antibody
  • Dmel\\CG14884 antibody
  • Jab1 antibody
  • jab1/csn5 antibody
  • JadBp antibody
  • l(3)89Cf antibody
  • l(3)L4032 antibody
  • l(3)M203 antibody
  • MGC76063 antibody
  • MOV-34 antibody
  • Mov34 antibody
  • quo antibody
  • SGN5 antibody
  • zgc:73130 antibody

Protein level used designations for COPS5

CG14884-PA , CG14884-PB , COP9 complex subunit 5 , CSN5-PA , CSN5-PB , JUN activation domain-binding protein-1 , Jun activation domain binding protein , drosophila COP9 signalosome homolog 5 , COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) , COP9 signalosome complex subunit 5 , signalosome subunit 5 , COP9 signalosome subunit 5 , COP9 signalosome complex subunit 5-like , COP9 complex S5 , Jun activation domain-binding protein 1 , Jun coactivator , Kip1 C-terminus-interacting protein 2 , COP9 constitutive photomorphogenic-like subunit 5 , c-Jun activation domain binding protein-1 , 38 kDa Mov34 homolog , COP9 constitutive photomorphogenic homolog subunit 5 , jun activation domain-binding protein 1 , COP9 (constitutive photomorphogenic) homolog, subunit 5

GENE ID SPECIES
42000 Drosophila melanogaster
704584 Macaca mulatta
507179 Bos taurus
744682 Pan troglodytes
394714 Xenopus (Silurana) tropicalis
6044976 Culex quinquefasciatus
6104199 Brugia malayi
9537583 Verticillium alfalfae VaMs.102
9938819 Loa loa
100305144 Oncorhynchus mykiss
100388876 Callithrix jacchus
100476549 Ailuropoda melanoleuca
100589547 Nomascus leucogenys
26754 Mus musculus
393698 Danio rerio
426579 Gallus gallus
477901 Canis lupus familiaris
100125955 Sus scrofa
10987 Homo sapiens
312916 Rattus norvegicus
444720 Xenopus laevis
177342 Caenorhabditis elegans
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