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Browse our anti-COPS6 (COPS6) Antibodies

Full name:
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) Antibodies (COPS6)
On www.antibodies-online.com are 37 COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) Antibodies from 10 different suppliers available. Additionally we are shipping COPS6 Proteins (11) and many more products for this protein. A total of 52 COPS6 products are currently listed.
Synonyms:
CG6932, CH6, CSN6, Dch6, Dmel\\CG6932, MOV34-34KD, Sgn3, VIP/MOV34, zgc:112075
list all antibodies Gene Name GeneID UniProt
COPS6 304343  
COPS6 26893 O88545
COPS6 10980 Q7L5N1

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Most Popular Reactivities for anti-COPS6 (COPS6) Antibodies

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anti-Rat (Rattus) COPS6 Antibodies:

anti-Mouse (Murine) COPS6 Antibodies:

anti-Human COPS6 Antibodies:

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Top referenced anti-COPS6 Antibodies

  1. Human Polyclonal COPS6 Primary Antibody for WB - ABIN2788037 : Pick, Golan, Zimbler, Guo, Sharaby, Tsuge, Hofmann, Wei: The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. in PLoS ONE 2012 (PubMed)

More Antibodies against COPS6 Interaction Partners

Fruit Fly (Drosophila melanogaster) COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

  1. the 2.5A crystal structure of MPN (show PRSS27 Antibodies) domain from Drosophila melanogaster CSN6.

Zebrafish COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

  1. Findings indicate that cops6 plays an anti-apoptotic role during segmentation.

Mouse (Murine) COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

  1. results define a mechanism for the regulation of Myc (show MYC Antibodies) stability through the CSN-Cullin-Fbxw7 (show FBXW7 Antibodies) axis and provide insights into the correlation of CSN6 overexpression with Myc (show MYC Antibodies) stabilization/activation during tumorigenesis

  2. loss of CSN6 enhances p53 (show TP53 Antibodies)-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2 (show MDM2 Antibodies)-p53 (show TP53 Antibodies) signaling pathway

Human COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

  1. CSN6 positively regulates c-Jun (show JUN Antibodies) in a MEKK1 (show MAP3K1 Antibodies)-dependent manner

  2. our results indicate that CSN6 is a positive regulator of E6AP (show ube3a Antibodies) and is important for cervical cancer development.

  3. CSN6 interacts with p27(Kip1 (show CDKN1B Antibodies)) and facilitates ubiquitin-mediated degradation of p27(Kip1 (show CDKN1B Antibodies)).

  4. Findings indicate that the deregulation of beta-catenin (show CTNNB1 Antibodies) by extracellular signal-regulated kinase 2 (ERK2 (show MAPK1 Antibodies))-activated CSN6 protein is important for colorectal cancer (CRC (show CALR Antibodies)) development.

  5. Analyses of the pseudo metal-binding motif in CSN6 suggest that the loss of two key histidine residues may contribute to the lack of catalytic activity in CSN6.

  6. Data suggest that CSN6 is an important negative regulator of p57 (Kip2 (show CDKN1C Antibodies)) , and that overexpression of CSN6 in many types of cancer could lead to decreased expression of p57 (Kip2 (show CDKN1C Antibodies)) and result in promoted cancer cell growth.

  7. COPS6 is a target gene of the BACH1 (show BACH1 Antibodies) transcription factor according to ChIP-seq analysis in HEK (show EPHA3 Antibodies) 293 cells.

  8. loss of CSN6 enhances p53 (show TP53 Antibodies)-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2 (show MDM2 Antibodies)-p53 (show TP53 Antibodies) signaling pathway

  9. critical role of caspase 8 (show CASP8 Antibodies) in the processing of CSN6.

  10. For the first time our data demonstrate that CSN-mediated deneddylation can be regulated by active Casp3 (show CASP3 Antibodies) and that the CSN executes a specific function during the apoptotic process.

COPS6 Antigen Profile

Antigen Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.

Alternative names and synonyms associated with COPS6

  • COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) (COPS6) antibody
  • COP9 signalosome subunit 6 (Cops6) antibody
  • COP9 complex homolog subunit 6 (CSN6) antibody
  • COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) (cops6) antibody
  • COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) (Cops6) antibody
  • COP9 signalosome subunit 6 (COPS6) antibody
  • Protein CSN-6 (csn-6) antibody
  • CG6932 antibody
  • CH6 antibody
  • CSN6 antibody
  • Dch6 antibody
  • Dmel\\CG6932 antibody
  • MOV34-34KD antibody
  • Sgn3 antibody
  • VIP/MOV34 antibody
  • zgc:112075 antibody

Protein level used designations for COPS6

COP9 (constitutive photomorphogenic) homolog, subunit 6 , COP9 constitutive photomorphogenic homolog subunit 6 , COP9 signalosome complex subunit 6 , CG6932-PA , CSN6-PA , drosophila COP9 signalosome homolog 6 , COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) , COP9 (constitutive photomorphogenic), subunit 6 , COP9 complex S6 , JAB1-containing signalosome subunit 6 , SGN6 , signalosome subunit 6 , COP9 signalosome subunit 6 , COP9 subunit 6 (MOV34 homolog, 34 kD) , H_NH0506M12.12 , MOV34 homolog, 34 kD , hVIP , vpr-interacting protein

GENE ID SPECIES
479738 Canis lupus familiaris
304343 Rattus norvegicus
42661 Drosophila melanogaster
463587 Pan troglodytes
550465 Danio rerio
26893 Mus musculus
512756 Bos taurus
100125954 Sus scrofa
100171609 Pongo abelii
10980 Homo sapiens
178289 Caenorhabditis elegans
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