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Browse our COPS8 Proteins (COPS8)

Full name:
COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) Proteins (COPS8)
On www.antibodies-online.com are 12 COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) Proteins from 5 different suppliers available. Additionally we are shipping COPS8 Antibodies (63) and many more products for this protein. A total of 83 COPS8 products are currently listed.
Synonyms:
9430009J09Rik, AA408242, CG13383, CG33297, CG42522, CH8, CONSTITUTIVE PHOTOMORPHOGENIC 9, COP9, COP9 SIGNALOSOME SUBUNIT 8, cops8, CSN8, Dch8, DDBDRAFT_0167123, DDBDRAFT_0233107, DDB_0167123, DDB_0233107, DL3095C, Dmel\\CG42522, Dmel_CG13383, EMB143, EMBRYO DEFECTIVE 143, FCAALL.131, FUS7, FUSCA 7, FUSCA PROTEIN FUS7, l(2)SH2 1829, l(2)SH1829, MGC76051, MGC80215, MGC86182, SGN8, zgc:56319, zgc:86840
list all proteins Gene Name GeneID UniProt
COPS8 108679 Q8VBV7
COPS8 10920 Q99627
COPS8 363283 Q6P4Z9

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COPS8 Proteins (COPS8) by Origin

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Top referenced COPS8 Proteins

  1. Human COPS8 Protein expressed in Escherichia coli (E. coli) - ABIN667600 : Bech-Otschir, Kraft, Huang, Henklein, Kapelari, Pollmann, Dubiel: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. in The EMBO journal 2001 (PubMed)
    Show all 2 references for ABIN667600

More Proteins for COPS8 Interaction Partners

Fruit Fly (Drosophila melanogaster) COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) interaction partners

  1. Mutants in protein phosphatase type 2A (PP2A (show PPP2R2B Proteins)) also display reduced genome-wide H3 dephosphorylation, and sites of H3 phosphorylation that do not contain heat shock genes remain transcriptionally active during heat shock in PP2A (show PPP2R2B Proteins) mutants.

  2. CSN8 is present exclusively as part of the CSN holo-complex, and lack of CSN8 in the mutants leads to CSN instability. Consistent with this, Cullin (show CUL5 Proteins) deneddylation is impaired in the csn8(null) mutants.

Mouse (Murine) COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) interaction partners

  1. CSN8/CSN promotes the ubiquitination and degradation of misfolded proteins and protects against cardiac proteotoxicity, and cullin-RING ligases participate in degradation of cytosolic misfolded proteins.

  2. Csn8 exerts profound impacts on hepatic ubiquitin-proteasome system function and is critical to the stability of the pro-apoptotic protein Bim (show BCL2L11 Proteins).

  3. CSN8/COP9 signalosome regulates both proteasome-mediated proteolysis and the autophagic-lysosomal pathway, critical to the removal of oxidized proteins in the heart.

  4. Data indicate that a decreased level of Csn8 accelerated cell growth and shortened G1 duration. (show COPS5 Proteins)

  5. Likely through regulating the expression of Rab7 (show RAB7A Proteins), Csn8/CSN plays a critical role in autophagosome maturation in myocardium.

  6. The Csn8 is essential to the ability of mature hepatocytes to proliferate effectively in response to hepatic injury.

  7. Csn8/CSN plays an essential role in cullin deneddylation, UPS-mediated degradation of a subset of proteins, and the survival of cardiomyocytes

Arabidopsis thaliana COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) interaction partners

  1. while constitutively photomorphogenic9 (COP9) signalosome (CSN) mutants can complete embryogenesis and are able to germinate, they progressively lose meristem activity upon germination until they become unable to sustain growth

  2. This review provides an overview of the highly complex regulation of CULLIN-RING E3 ubiquitin ligase (show MUL1 Proteins) activity by COP9 signalosome (CSN), and the many roles of the CSN in plant development and defense.

  3. SMAP1 (show SMAP1 Proteins) interacts with the COP9 signalosome.

  4. study concludes that the COP9 signalosome maintains a precise regulation of eIF3e (show EIF3E Proteins) levels, which is necessary for normal development in Arabidopsis

  5. COP9 has a role in ethylene signaling.

  6. COP9 signalosome- and 26S proteasome (show Psmd4 Proteins)-dependent regulation of SCFTIR1 accumulation in Arabidopsis

Human COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) interaction partners

  1. Data indicate that silencing of Csn8 caused an increased growth rate, whereas silencing of Csn5 (show COPS5 Proteins) impaired proliferation in HeLa cells.

  2. miR (show MLXIP Proteins)-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 (show CARD10 Proteins) and COPS8, inhibiting GPCR (show NMUR1 Proteins)-mediated activation of NF-kappaB (show NFKB1 Proteins).

  3. analysis of the COP9 signalosome and its common architecture with the 26S proteasome (show Psmd4 Proteins) lid and eIF3 (show EIF3A Proteins)

  4. DDB2 (show DDB2 Proteins) and CSA (show ERCC8 Proteins) are each integrated into nearly identical complexes via interaction with DDB1 (show DDB1 Proteins). Both complexes contain cullin 4A (show CUL4A Proteins) and Roc1 (show RIT1 Proteins) and display ubiquitin ligase activity. They also contain the COP9 signalosome (CSN)

  5. The COP9 signalosome (CSN) controls NF-kappaB (show NFKB1 Proteins) by deubiquitinylation of IkappaBalpha (show NFKBIA Proteins).

  6. COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination

COPS8 Protein Profile

Protein Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with COPS8

  • COP9 complex homolog subunit 8 (CSN8)
  • COP9 constitutive photomorphogenic homolog subunit 8 (csn8)
  • COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) (COPS8)
  • MGC80215 protein (MGC80215)
  • COP9 signalosome complex subunit 8 (CSN8)
  • COP9 signalosome complex subunit 8 (csn8)
  • COP9 (constitutive photomorphogenic) homolog, subunit 8 (cops8)
  • COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana) (Cops8)
  • COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) (cops8)
  • COP9 signalosome complex subunit 8 (COP9)
  • COP9 signalosome subunit 8 (COPS8)
  • COP9 signalosome subunit 8 (Cops8)
  • 9430009J09Rik protein
  • AA408242 protein
  • CG13383 protein
  • CG33297 protein
  • CG42522 protein
  • CH8 protein
  • CONSTITUTIVE PHOTOMORPHOGENIC 9 protein
  • COP9 protein
  • COP9 SIGNALOSOME SUBUNIT 8 protein
  • cops8 protein
  • CSN8 protein
  • Dch8 protein
  • DDBDRAFT_0167123 protein
  • DDBDRAFT_0233107 protein
  • DDB_0167123 protein
  • DDB_0233107 protein
  • DL3095C protein
  • Dmel\\CG42522 protein
  • Dmel_CG13383 protein
  • EMB143 protein
  • EMBRYO DEFECTIVE 143 protein
  • FCAALL.131 protein
  • FUS7 protein
  • FUSCA 7 protein
  • FUSCA PROTEIN FUS7 protein
  • l(2)SH2 1829 protein
  • l(2)SH1829 protein
  • MGC76051 protein
  • MGC80215 protein
  • MGC86182 protein
  • SGN8 protein
  • zgc:56319 protein
  • zgc:86840 protein

Protein level used designations for COPS8

CG42522-PB , CSN8-PB , Cop9 signalosome subunit 8 , drosophila COP9 signalosome homolog 8 , lethal (2) SH1829 , COP9 signalosome complex subunit 8 , signalosome subunit 8 , COP9 signalosome subunit 8 , MGC80215 protein , COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) , COP9 (constitutive photomorphogenic) homolog, subunit 8 , COP9 homolog , JAB1-containing signalosome subunit 8 , COP9 constitutive photomorphogenic homolog subunit 8 , hCOP9 , SGN8

GENE ID SPECIES
49077 Drosophila melanogaster
394711 Xenopus (Silurana) tropicalis
424020 Gallus gallus
443917 Xenopus laevis
8620221 Dictyostelium discoideum AX4
100286467 Salmo salar
460043 Pan troglodytes
477417 Canis lupus familiaris
540493 Bos taurus
447626 Xenopus laevis
108679 Mus musculus
100171561 Pongo abelii
393198 Danio rerio
827049 Arabidopsis thaliana
10920 Homo sapiens
363283 Rattus norvegicus
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