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CDK8-CycC may serve as transcriptional cofactors for EcR-dependent transcription.
observed biochemical association between Integrator proteins and cyclin C/Cdk8 (show CDK8 Proteins), and that overexpression of a kinase-dead Cdk8 (show CDK8 Proteins) causes snRNA misprocessing
our results suggest that mTORC1 activation in NAFLD and insulin (show INS Proteins) resistance results in down-regulation of the CDK8 (show CDK8 Proteins)-CycC complex and elevation of lipogenic protein expression.
results suggest that CCNC temporarily protects SRC-2 (show NCOA2 Proteins) against degradation and this event is involved in the transcriptional regulation of SRC-2 (show NCOA2 Proteins) cell cycle target genes.
Cancer-mediated CDK8 (show CDK8 Proteins) point mutations (D173A and D189N) change the binding pattern of cdk8 (show CDK8 Proteins) to its partner, CycC.
cyclin-C-CDK (show CDK4 Proteins) complexes phosphorylate the Notch1 (show NOTCH1 Proteins) intracellular domain (ICN1) and promote ICN1 degradation
analysis of the structure-kinetic relationship of the cyclin-dependent kinase 8 (CDK8 (show CDK8 Proteins))/cyclin C (CycC) complex
Silencing beta-catenin gene may induce changes of cell cycle and in cyclin B1 and cyclin C protein expression.
2.2-A crystal structure of CDK8 (show CDK8 Proteins)/CycC in complex with sorafenib; CDK8 (show CDK8 Proteins) structure reveals a unique CycC recognition helix that explains the specificity of the CDK8 (show CDK8 Proteins)/CycC pair and discrimination among the highly promiscuous binding in the CDK (show CDK4 Proteins)/cyclin (show PCNA Proteins) family
Studies establish cyclin C as a critical regulator of the G(0)/G(1) transition of human HSPCs and suggest that modulating cyclin C levels may be useful for HSC (show FUT1 Proteins) expansion and more efficient engraftment.
The present observations suggest different cellular functions of cyclin C in neurons and astrocytes in alzheimer's disease.
A cellular pool of cyclin C combines with cdk3 (show CDK3 Proteins) to stimulate pRb (show RB1 Proteins) phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
these data indicate that CycC activates adipogenesis in part by stimulating the transcriptional activity of C/EBPalpha (show CEBPA Proteins).
cyclin C connects stress-induced mitochondrial hyperfission and programmed cell death in mammalian cells.
Data show that the isolated 3.6-KB promoter fragment alone is not sufficient for the complete physiological modulation of cyclin C RNA.
Results identify LSF (show TFCP2 Proteins) as only the second known target (in addition to pRb (show PGR Proteins)) of cyclin C/CDK2 (show CDK2 Proteins) activity during progression from quiescence to early G(1).
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.
, SRB11 homolog
, dJ199J3.4 (cyclin C)