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miR (show MYLIP Proteins)-15/16 and CPEB co-regulate cyclin E1 (show CCNE1 Proteins) mRNA.
cyclin E (show CCNE1 Proteins) is dynamically and highly conjugated to SUMO2 (show SUMO2 Proteins)/3 on chromatin, independently of Cdk2 (show CDK2 Proteins) activity and origin activation.
These results show that cyclin E (show CCNE1 Proteins) destruction at the midblastula transition requires both phosphorylation and nuclear import, as well as proteasomal activity.
These observations indicate an absolute requirement of cyclin E2 for Xenopus embryogenesis.
In breast cancer patients, high levels of HMGA1 (show HMGA1 Proteins) and CCNE2 expression are associated with the YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) signature.
data suggests the potential role of monomorphic morphology, high cyclin E2 and Ki67 (show MKI67 Proteins) expression as adverse prognostic factors for TNKLPD
miR (show MLXIP Proteins)-144-5p functions as tumour suppressor in BC cells. CCNE1 (show CCNE1 Proteins) and CCNE2 were directly regulated by miR (show MLXIP Proteins)-144-5p and might be good prognostic markers for survival of bladder cancer patients
Our study shows miR (show MLXIP Proteins)-25 is overexpressed in small cell lung cancer and acting as oncogenic regulator by regulating cyclin E2.
Results suggest that the miR (show MLXIP Proteins)-30d-5p/CCNE2 axis may contribute to NSCLC cell proliferation and motility.
Data indicate that miR (show MLXIP Proteins)-26a overexpression inhibited pancreatic cancer cell growth by the downregulation of cyclin E2 expression.
In cancer cells Fbw7 (show FBXW7 Proteins), fails to effectively target cyclin E2 for proteosomal degradation.
Cyclin E2 induction of genomic instability by a mechanism distinct from cyclin E1 (show CCNE1 Proteins) indicates that these two proteins have unique functions in a cancer setting.
protein and mRNA expressions of Cyclin E2 in nasopharyngeal carcinoma
Tamoxifen resistant tumors displayed enriched expression of genes related to cell cycle and proliferation, as well as elevated activity of E2F (show E2F1 Proteins) transcription factors.
These results highlight a new role for E-type cyclins (Ccne1 (show CCNE1 Proteins) and Ccne2) as important regulators of male meiosis.
These findings define a molecular function for E type cyclins (cyclins E1 and E2) in cell cycle reentry and reveal a differential requirement for cyclin E (show CCNE1 Proteins) in normal versus oncogenic proliferation.
During embryonic development, the needs for this cyclin (show PCNA Proteins) can be overcome in mitotic cycles but not in endoreplicating cells.
We propose that such increased E2F (show E2F1 Proteins) activity stabilizes cyclin E (show CCNE1 Proteins) and contributes to establish the high and persistent levels of the protein commonly found in human neoplasias.
CaM (show Calm2 Proteins)-dependent cyclin E (show CCNE1 Proteins)/CDK2 (show CDK2 Proteins) activity is mediator of known Ca2 (show CA2 Proteins)+ sensitivity of G1/S transition of vascular smooth muscle cells.
This work indicates that-in addition to their function as CDK (show CDK4 Proteins) activators-E cyclins play kinase-independent functions in cell-cycle progression.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.
, G1/S-specific cyclin-E2
, g1/S-specific cyclin-E2-like
, G1/S-specific cyclin-E1