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Kbtbd5 regulates skeletal muscle myogenesis through the regulation of E2F1 (show E2F1 ELISA Kits)-DP1 (show REEP5 ELISA Kits) activity
Cell cycle suppression by Cdk5 (show CDK5 ELISA Kits) is made through the formation of a previously unknown complex consisting of the p35 (show CDK5R1 ELISA Kits)-Cdk5 (show CDK5 ELISA Kits) dimer and E2F1 (show E2F1 ELISA Kits), which excludes the E2F1 (show E2F1 ELISA Kits) cofactor, DP1 (show REEP5 ELISA Kits), thus inhibiting E2F1 (show E2F1 ELISA Kits) binding to the promoters of various cell cycle genes.
Persistent PP2A expression prevented the appearance of the phosphorylated form of DP-1 required for cellular differentiation and reversal of dysplasia after loss of oncogene (show RAB1A ELISA Kits) expression.
Results show that Dp1 (show REEP5 ELISA Kits) is largely dispensable for embryonic development, despite the absolute extraembryonic requirement for Dp1 (show REEP5 ELISA Kits).
Here, the authors show that an acidic region of DP1 (show PTGDR ELISA Kits), whose function has remained elusive, binds to the plekstrin homology (PH) domain of the p62 (show GTF2H1 ELISA Kits) subunit of TFIIH (show GTF2H1 ELISA Kits) that contributes to transcriptional activation.
role for E2F1 (show E2F1 ELISA Kits) and TFDP1 in the transcriptional regulation of PITX1 (show PITX1 ELISA Kits) in articular chondrocytes
According to our study results, the gene TFDP1 and the cell cycle pathway are strongly associated with high-grade glioblastoma multiforme (GBM); this result may provide new insights into the pathogenesis of GBM.
Amplification of CUL4A (show CUL4A ELISA Kits), IRS2 (show IRS2 ELISA Kits), and TFDP1 genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma.
The TFDP1 indel84 mutation generates a gain-of-function phenotype by increasing cell proliferation, migration, and invasion of colorectal cancer cells.
somatic mutations in DP-1 (show PTGDR ELISA Kits) uncouple normal control of the E2F (show E2F1 ELISA Kits) pathway, and thus define a new mechanism that could contribute to aberrant proliferation in tumor cells
The authors demonstrate that adenovirus E1A (show BCKDHA ELISA Kits) binds to E2F/DP (show E2F1 ELISA Kits)-1 (show PTGDR ELISA Kits) complexes through a direct interaction with DP-1 (show PTGDR ELISA Kits) and may selectively activate a subset of E2F (show E2F1 ELISA Kits)-regulated cellular genes during infection.
the DP-1 (show PTGDR ELISA Kits) "Stabilon" domain was a C-terminal acidic motif and was quite important for DP-1 (show PTGDR ELISA Kits) stability.
13q34 amplification may be of relevance in tumor progression of breast cancers by inducing overexpression of CUL4A (show CUL4A ELISA Kits) and TFDP1, important in cell cycle regulation. These genes were also overexpressed in non-basal-like tumor samples.
TFDP1, CUL4A (show CUL4A ELISA Kits), and CDC16 (show CDC16 ELISA Kits) are probable targets of an amplification mechanism and therefore may be involved, together or separately, in development and/or progression of some hepatocellular carcinomas
The authors propose that these dual functions of DP1 can promote and stabilize biphasic Wnt (show WNT2 ELISA Kits)-on and Wnt (show WNT2 ELISA Kits)-off states in response to a gradual gradient of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signalling to determine differential cell fates.
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.
RNA-binding protein MEX3A
, transcription factor Dp-1, like
, transcription factor Dp-1
, Transcription factor Dp-1
, transcription factor Dp-1-like
, DRTF1-polypeptide 1
, E2F dimerization partner 1
, cell cycle regulatory transcription factor DP1
, E2F-related transcription factor
, transcription factor Dp-1 a