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FOXO4 has an inhibitory effect in clearcell renal carcinoma (show TSC2 ELISA Kits) cells, at least in part through inducing apoptosis via upregulation of Bim (show BCL2L11 ELISA Kits) in the mitochondria-dependent pathway.
knockdown of Ku70 (show XRCC6 ELISA Kits) inhibited cell proliferation accompanying an increase in p27(kip1 (show CDKN1B ELISA Kits)) levels through interacting with FOXO4
miR (show MLXIP ELISA Kits)-664 functions as an oncogene (show RAB1A ELISA Kits) miRNA and has an important role in promoting human osteosarcoma cell proliferation by suppressing FOXO4 expression.
The data demonstrated that elevated miR (show MLXIP ELISA Kits)-150 targets FOXO4 expression and therefore regulates multiple genes expression, resulting in cervical cancer cell growth and survival.
Porphyromonas gingivalis-induced reactive oxygen species activate FOXO (show FOXO3 ELISA Kits) transcription factors through JNK (show MAPK8 ELISA Kits) signalling, and that FOXO1 (show FOXO1 ELISA Kits) controls oxidative stress responses, inflammatory cytokine production and cell survival.
Cox (show COX8A ELISA Kits) regression analysis indicated FoxO4 to be an independent prognostic factor in non-small cell lung cancers and suggested that FoxO4 might inhibit the process of EMT (show ITK ELISA Kits) in non-small cell lung cancers, and might therefore be a target for therapy.
FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 (show IDH1 ELISA Kits) expression.
data strongly suggest that increased PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits)-mediated metastatic invasiveness in CaP is associated with FOXO4 loss, and that mechanisms to induce FOXO4 re-expression might suppress CaP metastatic aggressiveness.
study demonstrated that miR (show MLXIP ELISA Kits)-1274a prompted gastric cancer cells growth and migration through dampening FOXO4 expression thus provided a potential target for human gastric cancer therapy
Data indicate that glycogen synthase kinase 3 beta (GSK3beta) and transcription factors FOXO1/3/4 promote hepatoma cell proliferation through type I insulin-like growth factor receptor (IGF-IR).
Foxo1 (show FOXO1 ELISA Kits), Foxo3a (show FOXO3 ELISA Kits), and Foxo4 in chondrocytes regulate endochondral bone formation.
The effect of Sirt1 (show SIRT1 ELISA Kits) stimulators on osteoclastogenesis was abrogated in cells lacking FoxO1 (show FOXO1 ELISA Kits), FoxO3 (show FOXO3 ELISA Kits), and FoxO4.
FoxO4 is collectively required to maintain MODYrelated gene networks, which in turn are required to enable a gene expression program that permits proper substrate selection (glucose versus fatty acids) for mitochondrial oxidative phosphorylation.
FoxO4 transcription factor is present during both oocyte and embryo in vivo maturation and FoxOs may regulate in vitro embryo development under stress conditions.
FoxO4 activates Arg1 (show ARG1 ELISA Kits) transcription in endothelial cells in response to MI, leading to downregulation of nitric oxide and upregulation of neutrophil infiltration to the infarct area.
Foxo1, Foxo3, and Foxo4 transcriptional network regulates autophagy and the ubiquitin-proteasome system during muscle atrophy.
Liver-specific ablation of FoxO1 (show FOXO1 ELISA Kits),FoxO3 (show FOXO3 ELISA Kits) and FoxO4 prevents the induction of glucose-6-phosphatase (show G6PC ELISA Kits) and the repression of glucokinase (show GCK ELISA Kits) during fasting, thus increasing lipogenesis.
FOXO1 (show FOXO1 ELISA Kits), FOXO3a (show FOXO3 ELISA Kits) and FOXO4, are indispensable for SIRT1 (show SIRT1 ELISA Kits)-dependent cell survival against oxidative stress.
FoxO1 (show FOXO1 ELISA Kits)/3/4 transcription factors play important roles in hepatic glucose homeostasis.
Mice lacking Foxo1 (show FOXO1 ELISA Kits), -3, and -4 in bipotential progenitors of osteoblast and adipocytes exhibit increased osteoblast number and high bone mass.
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
similar to Putative fork head domain transcription factor AFX1 (Forkhead box protein O4)
, forkhead box O4
, forkhead box protein O4-like
, fork head domain transcription factor AFX1
, forkhead box protein O4
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
, forkhead protein
, myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog
, forkhead box O1A