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investigated the functional effects of Coiled-Coil Domain Containing 80 (show CCD80 ELISA Kits)-loss-of-function during embryonic development and verified its interaction with gadd45beta2 in somitogenesis
regulated expression of gadd45beta genes in the anterior PSM is required for somite segmentation.
Data suggest that the increased expression of Gadd45beta induced by repeated administration of L-DOPA may be beneficial in patients with Parkinson's disease.
lower nucleus accumbens levels may affect Bdnf (show BDNF ELISA Kits) expression possibly leading to altered alcohol-drinking behavior
Gadd45b mediates the action of electroconvulsive shock-induced neural stem cell proliferation in the hippocampus.
Results suggest the possibility that differential Gadd45a (show GADD45A ELISA Kits), Gadd45b and Gadd45g (show GADD45G ELISA Kits) expression during development affects neurons, contributing cortical evolution and diversity
Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3 (show STAT3 ELISA Kits).
Modulation of the TGFbeta (show TGFB1 ELISA Kits)/NFkappaB/Gadd45b signaling pathway may provide a means to enhance the neuroprotective effect of Gadd45b in RGCs.
These results implicate Gadd45b as a learning-induced gene and a regulator of memory formation and are consistent with its potential role in active DNA demethylation in memory.
The data suggest that GADD45beta plays a complex role in regulating adaptive immunity and, depending on the model, either enhances or suppresses inflammation.
The current studies suggest that Gadd45b may be important for long-term hippocampus-dependent memory storage.
these data highlight a novel role for both Gadd45a (show GADD45A ELISA Kits) and Gadd45b in myeloid innate immune functions by differential modulation of p38 (show CRK ELISA Kits) and JNK (show MAPK8 ELISA Kits) signaling in granulocytes compared to macrophages.
Nrf2 (show GABPA ELISA Kits)-Gadd45b signaling axis exhibited a protective role in antimony trioxide-induced cell apoptosis.
our data demonstrate that C/EBPbeta (show CEBPB ELISA Kits) plays a central role in controlling Gadd45beta gene expression in articular chondrocytes
The gadd45b gene has both tumor suppressor and tumor promoter functions, dependent on the tissue/cell type and transforming event. (Review)
Gadd45B protects the liver through two entirely different processes: binding MKK7 (show MAP2K7 ELISA Kits) to block damaging signal transduction or binding CAR to coactivate anabolic transcription. (Review)
as such may play an unappreciated role in tumorigenesis. The exact mechanism of GADD45B inactivation and overexpression requires further investigation. GADD45B could be a potential therapeutic target for CRC (show CALR ELISA Kits) treatment in future
Cadmium chloride can induce DNA damage and increase expression levels of the gadd153 (show DDIT3 ELISA Kits) and gadd45beta promoters in HepG2 cells.
finding show there is an increased expression and decreased promoter binding of GADD45b in psychotic subjects.
GADD45beta is a novel pituitary tumor suppressor whose reexpression blocks proliferation, survival, and tumorigenesis
The association of GADD45beta expression and pathological grading of chondrosarcoma in the present study suggests that the immunohistochemical study of GADD45beta may be a specific diagnostic parameter for chondrosarcoma cell differentiation.
PXR (show NR1I2 ELISA Kits) activates the GADD45beta gene, increasing p38 MAPK (show MAPK14 ELISA Kits) phosphorylation, and leading HepG2 cells to change morphology and migrate.
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.
, growth arrest and DNA damage 45 beta
, Myeloid differentiation primary response protein MyD118
, growth arrest and DNA damage-inducible protein GADD45 beta
, growth arrest and DNA-damage-inducible protein GADD45 beta
, myeloid differentiation primary response gene 118
, myeloid differentiation primary response protein MyD118
, negative growth regulatory protein MyD118
, myeloid differentiation primary response
, growth arrest and DNA-damage-inducible 45 beta