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MDM2 T309G polymorphism is associated with endometrial cancer, especially in Caucasians.
WDR79 (show WRAP53 ELISA Kits) colocalized and interacted with USP7 (show USP7 ELISA Kits) in the nucleus of non-small cell lung cancer cells. This event, in turn, reduced the ubiquitination of Mdm2 and p53 (show TP53 ELISA Kits), thereby increasing the stability and extending the half-life of the two proteins.
p53 (show TP53 ELISA Kits) expression is low in luminal breast carcinomas than HER-2 (show ERBB2 ELISA Kits) and triple-negative subtypes. MDM2 amplification frequency was found to be 5.4% in total.
Our findings support no major role for the MDM2 SNP309 in KS development although it might influence the clinical outcome of KS in younger patients.
the present study is the first to provide evidence suggesting that miR610 directly targets MDM2 proto-oncogene (show RAB1A ELISA Kits) E3 ubiquitin protein ligase (show UBE2K ELISA Kits) to function as a tumor suppressor in glioma.
P53 (show TP53 ELISA Kits) and MDM2 mRNA and protein were elevated in endometrial polyps and endometrial adenocarcinoma and their expressions were correlated with clinical staging of endometrial adenocarcinoma.
Results suggest that microRNA miRNA-509-5p negatively regulates c-mdm2 proto-oncogene (show RAB1A ELISA Kits) protein (MDM2) expression via targeting the 3' untranslated region (3'-UTR (show UTS2R ELISA Kits)) of genes.
our study suggests that FOXQ1 (show FOXQ1 ELISA Kits) regulates prostate cancer cell proliferation and apoptosis by regulating BCL11A (show BCL11A ELISA Kits)/MDM2 expression and indicates that FOXQ1 (show FOXQ1 ELISA Kits) may serve as a potential therapeutic target for prostate cancer.
The cells with siRNA-MDM2 transfection had a greater decrease in cell viability.
expression of MDM2, somatostatin (show SST ELISA Kits) receptor 2A, and PD-L1 (show CD274 ELISA Kits) in follicular dendritic cell sarcoma
Inhibition of MDM2 re-sensitizes rapamycin resistant renal cancer cells via the activation of p53 (show TP53 ELISA Kits).
Inactivation of Mdm2 in sertoli cells triggers p53 (show TP53 ELISA Kits) activation and apoptosis as early as 15.5 days post conception with a significant increase in apoptosis.
These findings elucidate a critical role of Mdm2-p53-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.
These studies demonstrate that Mdm2 holds promise as a therapeutic target in combination with conventional therapy and may lead to new clinical therapies for Triple-negative breast cancers .
there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2/p53 (show TP53 ELISA Kits) axis which is important in normal hematopoiesis.
Study showed that demonstrate that Mdm2 intertwines the mammalian target of RAPA (show TRERF1 ELISA Kits), mTOR (show FRAP1 ELISA Kits), and the receptor kinase GRK2 (show ADRBK1 ELISA Kits) in regulating the desensitization/inactivation of the GPR17 (show GPR17 ELISA Kits) receptor
MDM2 mediates p73 (show ARHGAP24 ELISA Kits) ubiquitination
MDM2 supports the PRC2 mediated repression of lineage-specific genes in stem cells, independent of p53 (show TP53 ELISA Kits).
physiological activation of the 5S RNP (show RNPC3 ELISA Kits)-Mdm2-p53 (show TP53 ELISA Kits) pathway may contribute to functional decline of the hematopoietic system in a cell-autonomous manner over time.
Ribosomal proteins L11 (show RPL11 ELISA Kits) and L5 activate TAp73 (show TP73 ELISA Kits) by overcoming MDM2 inhibition.
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, double minute 2 protein
, p53-binding protein Mdm2