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Expressions of COX-2 (show COX2 ELISA Kits), p53 (show TP53 ELISA Kits), and MDM2 increased with oral submucous fibrosis progression.
LRRC8A (show LRRC8A ELISA Kits) is an essential regulator of cisplatin induced p53 (show TP53 ELISA Kits) protein activity and its downstream signaling involving increased expression of p21Waf1/Cip1 and MDM2, as well as activation of caspase-9 (show CASP9 ELISA Kits) and -3 in tumor cell lines.
These results indicate that p53 (show TP53 ELISA Kits)-independent upregulation of MDM2 by increasing selected clones may lead to oncogenesis.
The interaction between USP26 and Mdm2, and the subsequent deubiquitination of Mdm2, serves, most probably to regulate Mdm2. Future therapeutic modalities that interfere with the association between USP26 and Mdm2 will be used to destabilize the ligase in malignancies where it is upregulated.
VEGF-A (show VEGFA ELISA Kits) driven Mdm2 phosphorylation on Ser166 is dependent on the ERK1/2 (show MAPK1/3 ELISA Kits)/p90RSK (show RPS6KA1 ELISA Kits) signaling pathway in primary human endothelial cells.
Vif (show BTG1 ELISA Kits) stabilization by CBFbeta (show CBFB ELISA Kits) is mainly caused by impairing MDM2-mediated degradation.
AXL (show AXL ELISA Kits) overexpression or activation through growth arrest-specific 6 (Gas6 (show GAS6 ELISA Kits)) ligand stimulation increases MDMX (show MDM4 ELISA Kits) and MDM2 protein levels and decreases p53 (show TP53 ELISA Kits) activity.
p53 (show TP53 ELISA Kits) stabilization, along with antagonism of its signaling partners, MDM2 and MDMX (show MDM4 ELISA Kits), is a promising strategy for anticancer targeted therapy. (Review)
specific inhibitor of CDK4/6 (show CDK4 ELISA Kits) kinase blocked Her4 (show ERBB4 ELISA Kits)-induced stabilization of MDMX (show MDM4 ELISA Kits)-MDM2 and rescued p53 (show TP53 ELISA Kits) activity.
the study elucidates the regulatory mechanism of ORF50 stability and implicates that MDM2 may have a significant role in the maintenance of viral latency by lowering basal level of ORF50.
These results demonstrated a critical prosurvival role for MDM2 in the oocytes
we failed to detect any increase in p53 (show TP53 ELISA Kits) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (show TP53 ELISA Kits)-/- mice restored the fertility of females. This study is the first to show that Mdm2, but not Mdm4 (show MDM4 ELISA Kits), has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.
Inhibition of MDM2 re-sensitizes rapamycin resistant renal cancer cells via the activation of p53 (show TP53 ELISA Kits).
Inactivation of Mdm2 in sertoli cells triggers p53 (show TP53 ELISA Kits) activation and apoptosis as early as 15.5 days post conception with a significant increase in apoptosis.
These findings elucidate a critical role of Mdm2-p53-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.
These studies demonstrate that Mdm2 holds promise as a therapeutic target in combination with conventional therapy and may lead to new clinical therapies for Triple-negative breast cancers .
there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2/p53 (show TP53 ELISA Kits) axis which is important in normal hematopoiesis.
Study showed that demonstrate that Mdm2 intertwines the mammalian target of RAPA (show TRERF1 ELISA Kits), mTOR (show FRAP1 ELISA Kits), and the receptor kinase GRK2 (show ADRBK1 ELISA Kits) in regulating the desensitization/inactivation of the GPR17 (show GPR17 ELISA Kits) receptor
MDM2 mediates p73 (show ARHGAP24 ELISA Kits) ubiquitination
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, double minute 2 protein
, p53-binding protein Mdm2