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Results provide an alternative context-specific role of MDM2 in EMT (show ITK ELISA Kits), cell migration, metastasis, and therapy resistance.
MDM2 Amplification is associated with Adipocytic Tumors.
MDM2-309 polymorphism variant genotypes decrease the risk of recurrence in vocal leukoplakia.
The study found the frequency of Mdm2 SNP309 G/G in the Thai population to be very low, and suggests that this can explain to some extent the low incidence of severe inflammation and gastric cancer changes in the Thai population.
Data show that c-mdm2 proto-ocogene protein (MDM2) expression levels were correlated with hypoxia-inducible factor 1 (show HIF1A ELISA Kits), alpha subunit (show POLG ELISA Kits) (HIF1alpha (show HIF1A ELISA Kits)) levels, necrosis and proliferation index in malignant pleural mesothelioma.
the MDM2 SNP309 G/G homozygous genotype might be a risk factor for gastric cancer in Thailand
The proposed non-linear feedback control and perturbations compensation method for the p53 (show TP53 ELISA Kits)-mdm2 system can result in more efficient chemotherapy schemes where the infusion of medication will be better administered.
we demonstrated that rLZ-8 promoted the interaction between MDM2 and Slug (show SNAI2 ELISA Kits), resulting in Slug (show SNAI2 ELISA Kits) degradation
Both cases positive for MDM2 amplification showed MDM2 expression by immunohistochemistry. At last follow-up, both patients had died of disease
This review will focus on the aberrant splicing of tumor suppressor/oncogenes that belong to the DMP1 (show DMP1 ELISA Kits)-ARF-MDM2-p53 (show TP53 ELISA Kits) pathway
These findings elucidate a critical role of Mdm2-p53-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.
These studies demonstrate that Mdm2 holds promise as a therapeutic target in combination with conventional therapy and may lead to new clinical therapies for Triple-negative breast cancers .
there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2/p53 (show TP53 ELISA Kits) axis which is important in normal hematopoiesis.
Study showed that demonstrate that Mdm2 intertwines the mammalian target of RAPA (show TRERF1 ELISA Kits), mTOR (show FRAP1 ELISA Kits), and the receptor kinase GRK2 (show ADRBK1 ELISA Kits) in regulating the desensitization/inactivation of the GPR17 (show GPR17 ELISA Kits) receptor
MDM2 mediates p73 (show ARHGAP24 ELISA Kits) ubiquitination
MDM2 supports the PRC2 mediated repression of lineage-specific genes in stem cells, independent of p53 (show TP53 ELISA Kits).
physiological activation of the 5S RNP (show RNPC3 ELISA Kits)-Mdm2-p53 (show TP53 ELISA Kits) pathway may contribute to functional decline of the hematopoietic system in a cell-autonomous manner over time.
Ribosomal proteins L11 (show RPL11 ELISA Kits) and L5 activate TAp73 (show TP73 ELISA Kits) by overcoming MDM2 inhibition.
The Mdm2(SNP309-)(G) allele significantly impacts CRC (show SCRIB ELISA Kits) through mechanisms outside the p53 (show TP53 ELISA Kits) pathway.
MDM2 maintains homeostasis and long survival in podocytes preventing apoptosis.
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, double minute 2 protein
, p53-binding protein Mdm2