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Mdm2 P53 Binding Protein Homolog (Mouse) ELISA Kits (MDM2)
On www.antibodies-online.com are 1 Mdm2 P53 Binding Protein Homolog (Mouse) (MDM2) ELISA Kits from 1 different suppliers available. A total of 1 MDM2 products are currently listed.
Synonyms:
1700007J15Rik, AA415488, ACTFS, hdm2, HDMX, Mdm-2
list all ELISA KIts Gene Name GeneID UniProt
MDM2 4193 Q00987
Mouse MDM2 MDM2 17246 P23804

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Human Mdm2 P53 Binding Protein Homolog (Mouse) (MDM2) interaction partners

  1. Chromatin-bound MDM2 regulates serine metabolism and redox homeostasis independently of p53 (show TP53 ELISA Kits) status in tumor cells.

  2. Disruption of CK1alpha (show CSNK1A1 ELISA Kits) function in myeloma cells resulted in decreased Mdm2, increased p53 (show TP53 ELISA Kits) and p21 (show CDKN1A ELISA Kits) and reduced expression of beta-catenin (show CTNNB1 ELISA Kits) and AKT (show AKT1 ELISA Kits).

  3. In conclusion, the authors revealed that E3 ligase HDM2 promotes NEDD8 (show NEDD8 ELISA Kits) NEDDylation of HBx to enhance HBx stability and chromatin localization, which in turn favors HBx-dependent transcriptional regulation, cell proliferation, and hepatitis B virus-driven tumor growth.

  4. Results show that monoubiquitination of mutant p53 (show TP53 ELISA Kits) following DNA damage is MDM2 dependent and its RING domain is required for this modulation.

  5. Mdm2 acts as a positive regulator of NUB1 function, by modulating NUB1 ubiquitination on lysine 159.

  6. conclude that p16 is highly sensitive for retroperitoneal DDL. However, the lack of specificity limits the diagnostic utility compared with the more established markers MDM2 and CDK4 (show CDK4 ELISA Kits)

  7. HIV-1 Tat (show TAT ELISA Kits) appears to stabilise Mdm2, which in turn enhances Tat (show TAT ELISA Kits)-mediated viral replication.

  8. Overexpression of long non-coding RNA LOC572558 was associated with dephosphorylation of AKT (show AKT1 ELISA Kits), MDM2 and phosphorylation of p53 (show TP53 ELISA Kits) protein in bladder cancer cells.

  9. In conclusion, genetic variants of the p14ARF/MDM2/TP53 (show TP53 ELISA Kits) pathway are significantly related to overall survival and disease-free survival, and may be predictors of the prognosis of esophageal squamous cell carcinoma after surgery.

  10. 2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol shows excellent anti-breast cancer activity in vivo and in vitro and induces p53 (show TP53 ELISA Kits)-independent apoptosis, which is associated with MDM2 inhibition.

Mouse (Murine) Mdm2 P53 Binding Protein Homolog (Mouse) (MDM2) interaction partners

  1. The case emphasizes that MDM2 expression represents a possible pitfall in the diagnosis of spindle cell tumors. The differential diagnostic distinction between FDCS and a dedifferentiated liposarcoma is discussed.

  2. MDM2 is involved in fibroblast activation, mediating renal tubulointerstitial fibrosis via a p53 (show TP53 ELISA Kits)-independent pathway dependant on Notch1 (show NOTCH1 ELISA Kits) ubiquitination and proteasome degradation.

  3. These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 ELISA Kits)/Mdm2-Mdm4 (show MDM4 ELISA Kits) via a RING domain-mediated biochemical mechanism.

  4. both MDM2 and MDMX (show MDM4 ELISA Kits) deletion-caused pancreatic defects are completely rescued by loss of p53 (show TP53 ELISA Kits), verifying the crucial role of the MDM2 and/or MDMX (show MDM4 ELISA Kits) in regulating p53 (show TP53 ELISA Kits) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  5. Vif (show BTG1 ELISA Kits) stabilization by CBFbeta (show CBFB ELISA Kits) is mainly caused by impairing MDM2-mediated degradation.

  6. These results demonstrated a critical prosurvival role for MDM2 in the oocytes

  7. we failed to detect any increase in p53 (show TP53 ELISA Kits) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (show TP53 ELISA Kits)-/- mice restored the fertility of females. This study is the first to show that Mdm2, but not Mdm4 (show MDM4 ELISA Kits), has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.

  8. Inhibition of MDM2 re-sensitizes rapamycin resistant renal cancer cells via the activation of p53 (show TP53 ELISA Kits).

  9. Inactivation of Mdm2 in sertoli cells triggers p53 (show TP53 ELISA Kits) activation and apoptosis as early as 15.5 days post conception with a significant increase in apoptosis.

  10. These findings elucidate a critical role of Mdm2-p53-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.

MDM2 Antigen Profile

Antigen Summary

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Alternative names and synonyms associated with MDM2

  • MDM2 oncogene, E3 ubiquitin protein ligase (MDM2) Elisa Kit
  • transformed mouse 3T3 cell double minute 2 (Mdm2) Elisa Kit
  • 1700007J15Rik Elisa Kit
  • AA415488 Elisa Kit
  • ACTFS Elisa Kit
  • hdm2 Elisa Kit
  • HDMX Elisa Kit
  • Mdm-2 Elisa Kit

Protein level used designations for MDM2

E3 ubiquitin-protein ligase Mdm2 , Mdm2, p53 E3 ubiquitin protein ligase homolog , Mdm2, transformed 3T3 cell double minute 2, p53 binding protein , double minute 2, human homolog of; p53-binding protein , oncoprotein Mdm2 , double minute 2 protein , p53-binding protein Mdm2

GENE ID SPECIES
4193 Homo sapiens
17246 Mus musculus
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