Browse our anti-MDM4-binding Protein (MDM4) Antibodies

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anti-Mdm4-binding Protein Antibodies (MDM4)
On www.antibodies-online.com are 145 Mdm4-binding Protein (MDM4) Antibodies from 25 different suppliers available. Additionally we are shipping MDM4-binding Protein Proteins (10) and MDM4-binding Protein Kits (7) and many more products for this protein. A total of 170 MDM4-binding Protein products are currently listed.
Synonyms:
4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, HDMX, Mdmx, MRP1, wu:fa09h09, wu:fi33d10

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Top referenced anti-MDM4-binding Protein Antibodies

  1. Human Polyclonal MDM4-binding Protein Primary Antibody for IP, WB - ABIN151988 : Patton, Mayo, Singhi, Gudkov, Stark, Jackson: Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3. in Cancer research 2006 (PubMed)
    Show all 32 references for 151988

  2. Human Monoclonal MDM4-binding Protein Primary Antibody for ICC, IHC - ABIN969282 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 3 references for 969282

  3. Human Monoclonal MDM4-binding Protein Primary Antibody for WB - ABIN1449256 : Yang, Roe, Cliff, Williams, Ladbury, Cohen, Barford: Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. in The EMBO journal 2005 (PubMed)
    Show all 3 references for 1449256

  4. Human Polyclonal MDM4-binding Protein Primary Antibody for IHC, ELISA - ABIN1533176 : Shvarts, Bazuine, Dekker, Ramos, Steegenga, Merckx, van Ham, van der Houven van Oordt, van der Eb, Jochemsen: Isolation and identification of the human homolog of a new p53-binding protein, Mdmx. in Genomics 1997 (PubMed)
    Show all 2 references for 1533176

  5. Human Polyclonal MDM4-binding Protein Primary Antibody for IHC, ELISA - ABIN1532152 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)
    Show all 2 references for 1532152

  6. Cow (Bovine) Polyclonal MDM4-binding Protein Primary Antibody for WB - ABIN2774604 : Gilkes, Pan, Coppola, Yeatman, Reuther, Chen: Regulation of MDMX expression by mitogenic signaling. in Molecular and cellular biology 2008 (PubMed)

More Antibodies against MDM4-binding Protein Interaction Partners

Human Mdm4-binding Protein (MDM4) interaction partners

  1. These results demonstrate that cisplatin-mediated p53 (show TP53 Antibodies)(V172F) mutation regulates p53 (show TP53 Antibodies) stability at the normothermic temperature, but it is the increased recruitment of MDM4 by the homomeric or heteromeric mutant p53 (show TP53 Antibodies)(V172F) complex that inhibits p53 (show TP53 Antibodies)-dependent transactivation. This represents a novel cellular mechanism of p53 (show TP53 Antibodies) inhibition, and, thereby, induction of cisplatin resistance

  2. MDM4 protein is frequently abundant in the context of mutant p53 (show TP53 Antibodies) in basal-like breast cancer (BC) samples. MDM4 plays a critical role in the proliferation of these BC cells. MDM4 is crucial for the establishment and progression of tumours.

  3. Study used polymer statistics to estimate a global KD value for p53 (show TP53 Antibodies) binding to MdmX in the presence of the flexible linker and the intramolecular binding motif by assuming the flexible linker behaves as a wormlike chain. Calculations and measurements showed that the intramolecular binding motif reduces the apparent affinity of p53 (show TP53 Antibodies) for MdmX by a factor of 400.

  4. Data indicate that knockdown of otubain 1 (show OTUB1 Antibodies) protein (Otub1) reduced the levels of double minute 4 protein (MDMX).

  5. these data identify MDM4 as a nutrient-sensor able to inhibit mTORC1 and highlight its metabolism-related tumor-suppressing function.

  6. Data indicate that two single-nucleotide polymorphism (SNPs)rs10900598 and rs4245739, located at 3'-untranslated region (UTR (show UTS2R Antibodies)) of double minute 4 protein (MDM4) gene, contribute to clinical outcome of advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy.

  7. These findings suggest that Mdm2 (show MDM2 Antibodies) splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 Antibodies)/Mdm2 (show MDM2 Antibodies)-Mdm4 via a RING domain-mediated biochemical mechanism.

  8. AXL (show AXL Antibodies) overexpression or activation through growth arrest-specific 6 (Gas6 (show GAS6 Antibodies)) ligand stimulation increases MDMX and MDM2 (show MDM2 Antibodies) protein levels and decreases p53 (show TP53 Antibodies) activity.

  9. p53 (show TP53 Antibodies) stabilization, along with antagonism of its signaling partners, MDM2 (show MDM2 Antibodies) and MDMX, is a promising strategy for anticancer targeted therapy. (Review)

  10. identified a novel Her4 (show ERBB4 Antibodies)-induced posttranslational modification on MDMX

Zebrafish Mdm4-binding Protein (MDM4) interaction partners

  1. Data indicate that knockdown of the Mdm2 (show MDM2 Antibodies) and Mdm4 caused dramatic accumulation of mutant p53 protein (show TP53 Antibodies).

  2. crystal structure of N-terminal domain of Mdmx bound to 15-residue p53 (show TP53 Antibodies) peptide was determined; structure reveals that although principle features of Mdm2 (show MDM2 Antibodies)-p53 (show TP53 Antibodies) interaction are preserved, the Mdmx hydrophobic cleft on which the p53 (show TP53 Antibodies) peptide binds is altered

Mouse (Murine) Mdm4-binding Protein (MDM4) interaction partners

  1. The p53 (show TP53 Antibodies)-null mice with the highest level of Mdm4 tended to have multiple tumours. Mdm4 transgenic mice in various genetic backgrounds shows synergy in tumour development in vivo. Mdm4 may thus serve as a therapeutic target in cancers.

  2. These findings suggest that Mdm2 (show MDM2 Antibodies) splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 Antibodies)/Mdm2 (show MDM2 Antibodies)-Mdm4 via a RING domain-mediated biochemical mechanism.

  3. both MDM2 (show MDM2 Antibodies) and MDMX deletion-caused pancreatic defects are completely rescued by loss of p53 (show TP53 Antibodies), verifying the crucial role of the MDM2 (show MDM2 Antibodies) and/or MDMX in regulating p53 (show TP53 Antibodies) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  4. we failed to detect any increase in p53 (show TP53 Antibodies) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (show TP53 Antibodies)-/- mice restored the fertility of females. This study is the first to show that Mdm2 (show MDM2 Antibodies), but not Mdm4, has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.

  5. Data show that the Mdm4-p73 (show ARHGAP24 Antibodies) axis cannot override the dominant role of p53 (show TP53 Antibodies) in development and tumorigenesis and that Mdm4 and p73 (show ARHGAP24 Antibodies) interaction during development and tumorigenesis suggests new insight into the role of p53 (show TP53 Antibodies) family members.

  6. MDM4/HIPK2 (show HIPK2 Antibodies)/p53 (show TP53 Antibodies) cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.

  7. MDMx degradation associated with neuronal death occurs via caspase (show CASP3 Antibodies) activation in neurons, and that the progressive loss of MDMx protein represents a potential mechanism of Abeta (show APP Antibodies)-induced neuronal death during disease progression in AD

  8. our results show MDM4-MDM2 (show MDM2 Antibodies)/p53 (show TP53 Antibodies)-IGF1R (show IGF1R Antibodies) as an original regulatory mechanism for CNS regeneration

  9. Increased Mdm4-S mRNA levels might correlate with more aggressive cancers without encoding significant amounts of a potential oncoprotein.

  10. results reveal a novel p53 (show TP53 Antibodies)- and Mdm2 (show MDM2 Antibodies)-independent oncogenic function of Mdmx that provides new insight into the many cancers that overexpress Mdmx.

MDM4-binding Protein (MDM4) Antigen Profile

Antigen Summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alternative names and synonyms associated with MDM4-binding Protein (MDM4)

  • Mdm4 p53 binding protein homolog (mdm4) antibody
  • Mdm4 p53 binding protein homolog (mouse) (MDM4) antibody
  • Mdm4 p53 binding protein homolog (mouse) (Mdm4) antibody
  • transformed 3T3 cell double minute 4 homolog (mouse) (mdm4) antibody
  • transformed mouse 3T3 cell double minute 4 (Mdm4) antibody
  • 4933417N07Rik antibody
  • AA414968 antibody
  • AL023055 antibody
  • AU018793 antibody
  • AU021806 antibody
  • C85810 antibody
  • HDMX antibody
  • Mdmx antibody
  • MRP1 antibody
  • wu:fa09h09 antibody
  • wu:fi33d10 antibody

Protein level used designations for MDM4

double minute 4 protein , mdm2-like p53-binding protein , p53-binding protein Mdm4 , protein Mdm4 , MDM4-related protein 1 , double minute 4, human homolog of; p53-binding protein , protein Mdmx , Mdm4, transformed 3T3 cell double minute 4, p53 binding protein , double minute 4 homolog , transformed mouse 3T3 cell double minute 4

GENE ID SPECIES
398466 Xenopus laevis
4194 Homo sapiens
478939 Canis lupus familiaris
514225 Bos taurus
304798 Rattus norvegicus
334932 Danio rerio
17248 Mus musculus
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