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Browse our anti-MDM4-binding Protein (MDM4) Antibodies

Full name:
anti-Mdm4-binding Protein Antibodies (MDM4)
On www.antibodies-online.com are 131 Mdm4-binding Protein (MDM4) Antibodies from 21 different suppliers available. Additionally we are shipping MDM4-binding Protein Proteins (10) and MDM4-binding Protein Kits (7) and many more products for this protein. A total of 156 MDM4-binding Protein products are currently listed.
Synonyms:
4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, HDMX, Mdmx, MRP1, wu:fa09h09, wu:fi33d10

Most Popular Reactivities for anti-MDM4-binding Protein (MDM4) Antibodies

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anti-Human MDM4-binding Protein Antibodies:

anti-Rat (Rattus) MDM4-binding Protein Antibodies:

anti-Mouse (Murine) MDM4-binding Protein Antibodies:

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Top referenced anti-MDM4-binding Protein Antibodies

  1. Human Monoclonal MDM4-binding Protein Primary Antibody for EIA, IF - ABIN1108193 : Wunderlich, Ghosh, Weghorst, Berberich: MdmX represses E2F1 transactivation. in Cell cycle (Georgetown, Tex.) 2004 (PubMed)
    Show all 3 references for ABIN1108193

  2. Human Monoclonal MDM4-binding Protein Primary Antibody for ICC, IHC - ABIN969282 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 3 references for ABIN969282

  3. Human Monoclonal MDM4-binding Protein Primary Antibody for WB - ABIN1449256 : Yang, Roe, Cliff, Williams, Ladbury, Cohen, Barford: Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. in The EMBO journal 2005 (PubMed)
    Show all 3 references for ABIN1449256

  4. Human Polyclonal MDM4-binding Protein Primary Antibody for WB - ABIN2792185 : Danovi, Meulmeester, Pasini, Migliorini, Capra, Frenk, de Graaf, Francoz, Gasparini, Gobbi, Helin, Pelicci, Jochemsen, Marine: Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. in Molecular and cellular biology 2004 (PubMed)
    Show all 2 references for ABIN2792185

  5. Human Polyclonal MDM4-binding Protein Primary Antibody for IHC, ELISA - ABIN1533176 : Shvarts, Bazuine, Dekker, Ramos, Steegenga, Merckx, van Ham, van der Houven van Oordt, van der Eb, Jochemsen: Isolation and identification of the human homolog of a new p53-binding protein, Mdmx. in Genomics 1997 (PubMed)
    Show all 2 references for ABIN1533176

  6. Human Polyclonal MDM4-binding Protein Primary Antibody for IHC, ELISA - ABIN1532152 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)
    Show all 2 references for ABIN1532152

  7. Cow (Bovine) Polyclonal MDM4-binding Protein Primary Antibody for WB - ABIN2774604 : Gilkes, Pan, Coppola, Yeatman, Reuther, Chen: Regulation of MDMX expression by mitogenic signaling. in Molecular and cellular biology 2008 (PubMed)

More Antibodies against MDM4-binding Protein Interaction Partners

Human Mdm4-binding Protein (MDM4) interaction partners

  1. MDM4 SNP34091 status to be associated with reduced risk of breast cancer, in particular in individuals carrying the MDM2 (show MDM2 Antibodies) SNP309GG genotype, but not to be associated with either lung-, colon- or prostate cancer.

  2. The phosphate group of pTyr99 imposes extensive steric clashes with the C-terminus of p53 (show TP53 Antibodies) peptide and induces a significant lateral shift of the peptide ligand, decreasing the binding affinity of MDMX for p53 (show TP53 Antibodies).

  3. CETSA was able to validate stapled peptide binding to Mdm2 (show MDM2 Antibodies) and Mdm4.

  4. MDM4/HIPK2 (show HIPK2 Antibodies)/p53 (show TP53 Antibodies) cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.

  5. MDM4 rs4245739 single nucleotide polymorphism contributes to small cell lung cancer risk and support the notion that gene 3'-UTR (show UTS2R Antibodies) genetic variants, impacting miRNA-binding, might modify small cell lung cancer susceptibility.

  6. These results identify Mdmx growth dependency in wt p53 (show TP53 Antibodies) expressing breast cancer across a range of subtypes. Based on our findings, we propose that Mdmx targeting is an attractive strategy for treating breast cancer harboring wt p53 (show TP53 Antibodies)

  7. MDM4 overexpression is related to complex karyotype-acute myeloid leukemia (show BCL11A Antibodies) with wild-type TP53 (show TP53 Antibodies) and might play a pathogenic role by inhibiting p53 (show TP53 Antibodies)-signal pathway.

  8. MDMX exerts oncogenic activity via suppression of RB.

  9. We show using reporter gene assays and endogenous MDM4 expression analyses that miR (show MLXIP Antibodies)-191-5p and miR (show MLXIP Antibodies)-887 have a specific affinity for the rs4245739 SNP C-allele in prostate cancer

  10. MDM4 mutation identified in a glioma patient was associated with loss of the putative MDM4 target site. Therefore, let-7 binding to MDM4 is implicated in the DNA damage response

Zebrafish Mdm4-binding Protein (MDM4) interaction partners

  1. Data indicate that knockdown of the Mdm2 (show MDM2 Antibodies) and Mdm4 caused dramatic accumulation of mutant p53 protein (show TP53 Antibodies).

  2. crystal structure of N-terminal domain of Mdmx bound to 15-residue p53 (show TP53 Antibodies) peptide was determined; structure reveals that although principle features of Mdm2 (show MDM2 Antibodies)-p53 (show TP53 Antibodies) interaction are preserved, the Mdmx hydrophobic cleft on which the p53 (show TP53 Antibodies) peptide binds is altered

Mouse (Murine) Mdm4-binding Protein (MDM4) interaction partners

  1. Data show that the Mdm4-p73 (show ARHGAP24 Antibodies) axis cannot override the dominant role of p53 (show TP53 Antibodies) in development and tumorigenesis and that Mdm4 and p73 (show ARHGAP24 Antibodies) interaction during development and tumorigenesis suggests new insight into the role of p53 (show TP53 Antibodies) family members.

  2. MDM4/HIPK2 (show HIPK2 Antibodies)/p53 (show TP53 Antibodies) cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.

  3. MDMx degradation associated with neuronal death occurs via caspase (show CASP3 Antibodies) activation in neurons, and that the progressive loss of MDMx protein represents a potential mechanism of Abeta (show APP Antibodies)-induced neuronal death during disease progression in AD

  4. our results show MDM4-MDM2 (show MDM2 Antibodies)/p53 (show TP53 Antibodies)-IGF1R (show IGF1R Antibodies) as an original regulatory mechanism for CNS regeneration

  5. Increased Mdm4-S mRNA levels might correlate with more aggressive cancers without encoding significant amounts of a potential oncoprotein.

  6. results reveal a novel p53 (show TP53 Antibodies)- and Mdm2 (show MDM2 Antibodies)-independent oncogenic function of Mdmx that provides new insight into the many cancers that overexpress Mdmx.

  7. both MDM2 (show MDM2 Antibodies) and MDMX are required for monitoring p53 (show TP53 Antibodies) activity during lens development, and they may function independently or synergistically to control p53 (show TP53 Antibodies) and maintain normal lens morphogenesis

  8. Decreased Mdm4 levels improves the survival of mice expressing wild-type p53 (show TP53 Antibodies), but not that of mice expressing a p53 (show TP53 Antibodies) hypomorph lacking the proline-rich domain.

  9. identify Mdm4 as one of these key mRNAs that senses the defects in the spliceosomal machinery and transduces the signal to activate the p53 (show TP53 Antibodies) response

  10. The work demonstrates that the ability of MDM4 to enhance p53 (show TP53 Antibodies) stability is actually a specific property of MDM4 accomplished upon DNA damage.

MDM4-binding Protein (MDM4) Antigen Profile

Antigen Summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alternative names and synonyms associated with MDM4-binding Protein (MDM4)

  • Mdm4 p53 binding protein homolog (mdm4) antibody
  • Mdm4 p53 binding protein homolog (mouse) (MDM4) antibody
  • Mdm4 p53 binding protein homolog (mouse) (Mdm4) antibody
  • transformed 3T3 cell double minute 4 homolog (mouse) (mdm4) antibody
  • transformed mouse 3T3 cell double minute 4 (Mdm4) antibody
  • 4933417N07Rik antibody
  • AA414968 antibody
  • AL023055 antibody
  • AU018793 antibody
  • AU021806 antibody
  • C85810 antibody
  • HDMX antibody
  • Mdmx antibody
  • MRP1 antibody
  • wu:fa09h09 antibody
  • wu:fi33d10 antibody

Protein level used designations for MDM4

double minute 4 protein , mdm2-like p53-binding protein , p53-binding protein Mdm4 , protein Mdm4 , MDM4-related protein 1 , double minute 4, human homolog of; p53-binding protein , protein Mdmx , Mdm4, transformed 3T3 cell double minute 4, p53 binding protein , double minute 4 homolog , transformed mouse 3T3 cell double minute 4

GENE ID SPECIES
398466 Xenopus laevis
4194 Homo sapiens
478939 Canis lupus familiaris
514225 Bos taurus
304798 Rattus norvegicus
334932 Danio rerio
17248 Mus musculus
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