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Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.
investigated the function of the Cdk7 (show CDK7 ELISA Kits).cyclin (show PCNA ELISA Kits) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
This study demonstrates a requirement for MAT1 (show MAT1A ELISA Kits) in the operation of PGC-1 (show PPARGC1A ELISA Kits) coactivators that control cell metabolism.
study found that Mat1 (show MAT1A ELISA Kits) and Cdk7 (show CDK7 ELISA Kits) levels are undetectable in adipose tissues in vivo and downregulated during adipogenesis
The intrinsically programmed MAT1 (show MAT1A ELISA Kits) expression and fragmentation regulate granulopoiesis.
The cyclin H (show CCNH ELISA Kits)/cdk7 (show CDK7 ELISA Kits)/Mat1 (show MAT1A ELISA Kits) kinase activity is regulated by CK2 (show CSNK2A1 ELISA Kits) phosphorylation of cyclin H (show CCNH ELISA Kits).
Retinoid-induced G1 arrest and differentiation activation are associated with a switch to enzyme hypophosphorylation of retinoic acid receptor alpha (show RARA ELISA Kits).
interaction with MTA1 (show MTA1 ELISA Kits) and role in regulating estrogen receptor (show ESR1 ELISA Kits) transactivation functions
In response to ATRA, PML (show PML ELISA Kits)/RARalpha (show RARA ELISA Kits) is dissociated from CAK (show CCNH ELISA Kits), leading to MAT1 (show MAT1A ELISA Kits) degradation, G1 arrest, and decreased CAK (show CCNH ELISA Kits) phosphorylation of PML (show PML ELISA Kits)/RARalpha (show RARA ELISA Kits)
Retinoic-acid-induced RAR (show RARA ELISA Kits)-CAK (show CCNH ELISA Kits) signaling events appear to proceed intrinsically during granulocytic development of normal primitive hematopoietic cells. ALDH-governed RA availability may mediate this process by initiating RAR (show RARA ELISA Kits)-CAK (show CCNH ELISA Kits) signaling.
These results suggested that genetic variants in CAK (show CCNH ELISA Kits) genes, Cdk7 (show CDK7 ELISA Kits), cyclin H (show CCNH ELISA Kits), MAT1 (show MAT1A ELISA Kits), might modulate the risk of lung cancer in a gene-gene interaction mode, which consist to the biochemical interaction of corresponding proteins.
The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene.
CDK-activating kinase assembly factor MAT1
, cdk-activating kinase assembly factor mat1
, CDK7/cyclin H assembly factor
, CDK7/cyclin-H assembly factor
, RING finger protein MAT1
, menage a trois 1
, RING finger protein 66
, cyclin G1 interacting protein
, cyclin-G1-interacting protein
, menage a trois 1 (CAK assembly factor)
, menage a trois homolog 1, cyclin H assembly factor