Browse our anti-p130 (RBL2) Antibodies

Full name:
anti-Retinoblastoma-Like 2 (p130) Antibodies (RBL2)
On are 94 Retinoblastoma-Like 2 (p130) (RBL2) Antibodies from 20 different suppliers available. Additionally we are shipping p130 Proteins (4) and p130 Kits (3) and many more products for this protein. A total of 106 p130 products are currently listed.
P130, PRB2, Rb2, RBL2, RBR-2, RBR2, RRB2a

Most Popular Reactivities for anti-p130 (RBL2) Antibodies

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anti-Mouse (Murine) p130 Antibodies:

anti-Rat (Rattus) p130 Antibodies:

anti-Human p130 Antibodies:

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Top referenced anti-p130 Antibodies

  1. Human Polyclonal p130 Primary Antibody for EIA, WB - ABIN954473 : Schaffer, Park, Yiu, Conklin, Lin, Burkhart, Karnezis, Sweet-Cordero, Sage: Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. in Cancer research 2010 (PubMed)
    Show all 5 references for 954473

  2. Chicken Monoclonal p130 Primary Antibody for IF, IP - ABIN967863 : Fusaro, Wang, Chellappan: Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis. in Oncogene 2002 (PubMed)
    Show all 5 references for 967863

  3. Human Polyclonal p130 Primary Antibody for FACS, WB - ABIN656158 : Jowett, Curran, Johnson, Carless, Göring, Dyer, Cole, Comuzzie, MacCluer, Moses, Blangero: Genetic variation at the FTO locus influences RBL2 gene expression. in Diabetes 2010 (PubMed)
    Show all 2 references for 656158

More Antibodies against p130 Interaction Partners

Mouse (Murine) Retinoblastoma-Like 2 (p130) (RBL2) interaction partners

  1. Deletion of Rb or p130 leads to impaired repression of Sox2 (show SOX2 Antibodies), a defect amplified by inactivation of p53 (show TP53 Antibodies). Identify binding of pRb (show PGR Antibodies) and p130 to an enhancer with crucial regulatory activity on Sox2 (show SOX2 Antibodies) expression.

  2. In skeletal dysplasias cell cycle progression is compromised in the G1 phase due to reduced phosphorylation of the pocket protein p130 leading to inhibition of transcription factors of the E2F (show E2F1 Antibodies) family.

  3. Following stress exposure, E2F4 (show E2F4 Antibodies)-p130 complexes are lost rapidly along with the presence of E2F4 (show E2F4 Antibodies) at E2F (show E2F1 Antibodies)-containing B-Myb (show MYBL2 Antibodies) promoter sites.

  4. PRMT5 (show PRMT5 Antibodies) knockdown in non-Hodgkin lymphoma cell lines and primary lymphoma cells leads to RBL2 derepression and RB1 (show RB1 Antibodies) reactivation, which in turn inhibit PRC2 expression.

  5. Rb, p107 (show RBL1 Antibodies) and p130 epigenetically protect newly born cortical neurons from DNA damage and cell division

  6. The balance between phosphorylation and acetylation of Rb2/p130 is essential for its biological function in cell cycle control.

  7. Rb2 coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF (show CTCF Antibodies)) and BORIS (show CTCFL Antibodies) in T-antigen-positive but not in T-antigen-negative cells.

  8. Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and pRb (show PGR Antibodies) signal pathways interact with each other and form common p130/Gsk3beta (show GSK3b Antibodies)/beta-catenin (show CTNNB1 Antibodies) complex during MSC (show MSC Antibodies) cycle progression.

  9. Mutation of p107 (show RBL1 Antibodies) or p130 reduces survival of Rb-deficient myoblasts during differentiation.

  10. Gsk3beta (show GSK3b Antibodies), p130 and beta-catenin (show CTNNB1 Antibodies) form in MSC (show MSC Antibodies) a complex the functional role of which may be associated with activation of differentiation not coupled to cell cycle arrest.

Human Retinoblastoma-Like 2 (p130) (RBL2) interaction partners

  1. UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 (show RBL1 Antibodies) and p130 proteins

  2. Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation

  3. Statistical analysis revealed that Rbl2/p130 expression negatively correlates to its promoter methylation (r = -0.412) in tumor tissues.

  4. TGF-beta (show TGFB1 Antibodies) induced RBL2 expression through down-regulating miR (show MLXIP Antibodies)-93 in renal cancer cells

  5. the inactivation of RB1 (show RB1 Antibodies) or RB2/P130 in uncommitted bone marrow stromal cells facilitates the first steps of adipogenesis.

  6. expression profiling of miRNAs in high-grade serous ovarian carcinoma indicated miR (show MLXIP Antibodies)-106a and its family members were upregulated; findings suggest miR (show MLXIP Antibodies)-106a can repress expression of the retinoblastoma family member RBL2 and miR (show MLXIP Antibodies)-106a overexpression results in rapid tumor growth and poor differentiation

  7. PRMT5 (show PRMT5 Antibodies) knockdown in non-Hodgkin lymphoma cell lines and primary lymphoma cells leads to RBL2 derepression and RB1 (show RB1 Antibodies) reactivation, which in turn inhibit PRC2 expression.

  8. Low expression of RBL2 is associated with glioma.

  9. Silencing of RB1 (show RB1 Antibodies) but not RB2/P130 decreases proliferative activity and impairs the differentiation potential of human mesenchymal stem cells.

  10. Our hypothesis not only enrich the knowledge of the regulation of ALT, but also indicate that p130 may serve as a potential suppressor of ALT, and gene therapy of p130 may be used in cervical cancers.

p130 (RBL2) Antigen Profile

Antigen Summary

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Alternative names and synonyms associated with p130 (RBL2)

  • retinoblastoma-like 2 (p130) (RBL2) antibody
  • related to retinoblastoma2 (rrb2) antibody
  • retinoblastoma-like 2 (Rbl2) antibody
  • P130 antibody
  • PRB2 antibody
  • Rb2 antibody
  • RBL2 antibody
  • RBR-2 antibody
  • RBR2 antibody
  • RRB2a antibody

Protein level used designations for RBL2

retinoblastoma-like 2 (p130) , retinoblastoma-like protein 2 , retinoblastoma-like protein 2-like , CL1187_-3 , CL1187_-3(342) , CL1187_-3_ov , PZA00193 , RB , RRB2b , Retinoblastoma-related protein 2 , nPZA00193.2 , retinoblastoma-related protein 2a , 130 kDa retinoblastoma-associated protein , retinoblastoma-related protein 2 , P130 , PPAR-alpha-interacting complex protein 128 , PRB2 , PRIC128 , RBR-2

415721 Gallus gallus
467978 Pan troglodytes
478127 Canis lupus familiaris
533294 Bos taurus
100019136 Monodelphis domestica
100410298 Callithrix jacchus
100547227 Meleagris gallopavo
541652 Zea mays
19651 Mus musculus
81758 Rattus norvegicus
5934 Homo sapiens
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