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loss-of-function mutations in protection of telomeres 1 (POT1) co-segregated with Chronic lymphocytic leukemia.
the study identifies mutations in KRAS and POT1 as novel determinants of outcome after chemoimmunotherapy using chlorambucil and anti-CD20 (show MS4A1 ELISA Kits) treatment.
Lung fibroblasts deficient in Sirt1 (show SIRT1 ELISA Kits) or treated with a selective Sirt1 (show SIRT1 ELISA Kits) inhibitor exhibit increased cellular senescence and decreased TPP1 (show TPP1 ELISA Kits) levels, whereas Sirt1 (show SIRT1 ELISA Kits) overexpression and pharmacological activation protect against CS-induced TPP1 (show TPP1 ELISA Kits) reduction and telomeric DNA damage.
Binding of POT1-TPP1 (show TPP1 ELISA Kits) unfolds telomere secondary structure to assist loading of additional heterodimers.
We found that NEK6 (show NEK6 ELISA Kits)-mediated phosphorylation of TPP1 (show TPP1 ELISA Kits) Ser255 in G2/M phase regulates the association between telomerase activity and TPP1 (show TPP1 ELISA Kits). Furthermore, we found evidence that POT1 negatively regulates TPP1 (show TPP1 ELISA Kits) phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 mutant lacking its OB-fold domains
Coats plus is caused by a defect in POT1/CST (show GAL3ST1 ELISA Kits)-dependent telomere fill-in
Downregulation of Protection of Telomeres 1 expression in myelodysplastic syndromes with 7q deletion.
The conservation between fission yeast Tpz1-Pot1 and human TPP1 (show TPP1 ELISA Kits)-POT1 interactions resulted in mapping a human melanoma-associated (show ZNF654 ELISA Kits) POT1 mutation (A532P) to the TPP1 (show TPP1 ELISA Kits)-POT1 interface.
Missense variant p.R117C is associated with cardiac angiosarcoma in TP-53 (show TP53 ELISA Kits) negative Li-Fraumeni-like families. Mutation carriers show reduced telomere-bound POT1 levels, abnormally long telomeres and increased telomere fragility.
OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs
The tissue expression analysis indicated that the swine POT1 gene is differentially expressed in tissues including muscle, heart, liver, fat, kidney, lung, pancreas and spleen.
proliferation of cancer cells lacking POT1 is enabled by the attenuation of the ATR kinase pathway.
demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 (show TINF2 ELISA Kits) phenocopy the POT1a,b knockout setting without showing additional phenotypes
The results of this study found telomere uncapping by Pot1a inactivation resulted in an Atm (show ATM ELISA Kits)-dependent loss of cerebellar interneurons and granule neuron precursors in the mouse nervous system. The
shelterin protein TIN2 (show TINF2 ELISA Kits) can protect chromosome ends as a TRF2 (show TERF2 ELISA Kits)-tethered TIN2 (show TINF2 ELISA Kits)/TPP1 (show TPP1 ELISA Kits)/POT1 complex that lacks a physical connection to TRF1 (show TERF1 ELISA Kits)
Simultaneous inactivation of Pot1a and p53 (show TP53 ELISA Kits) resulted in endometrial intraepithelial carcinoma-like lesions in transgenic mice.
Telomere protection by TPP1 (show TPP1 ELISA Kits)/POT1 requires tethering to TIN2 (show TINF2 ELISA Kits).
POT1a degradation resulted in rapid and reversible activation of the ATR (show ATR ELISA Kits) pathway in G1 and S/G2 (show STRN3 ELISA Kits).
The ability of mPot1 to unfold the antiparallel tetraplex of the mouse telomeric DNA is required for telomerase-mediated telomere elongation.
TPP1 (show TPP1 ELISA Kits) deletion resulted in the release of POT1a and POT1b from chromatin and loss of these proteins from telomeres, indicating that TPP1 (show TPP1 ELISA Kits) is required for the telomere association of POT1a and POT1b but not for their stability.
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
POT1-like telomere end-binding protein
, protection of telomeres 1 homolog
, protection of telomeres protein 1
, POT1 protection of telomeres 1 homolog
, single-strand telomeric DNA-binding protein
, POT1 protection of telomeres 1 homolog (S. pombe)
, protection of telomeres 1
, protection of telomeres 1 homolog (S. pombe)
, protection of telomeres protein 1-like
, protection of telomeres 1A