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Data show that isoform beta2 of the heregulin (HRGbeta2) localizes at telomeres with the telomere-associated proteins TRF2 and RAP1.
Data indicate telomere-binding protein RAP1 (show RABGEF1 Proteins) as an interacting partner of isoform beta2 of the heregulin (show NRG1 Proteins) (HRGbeta2).
In pro-inflammatory macrophages, Rap1 promotes cytokine production via NFkappaB activation favoring a pro-inflammatory environment which may contribute to the development and progression of atherosclerosis.
Through a combination of biochemical, biophysical and structural approaches, we unveiled a unique mode of assembly between RAP1 (show RABGEF1 Proteins) and TRF2 (show TERF2 Proteins)
the conservation of Rap1 reflects its role in transcriptional regulation rather than a function at telomeres.
These findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its functional association with Rap1.
Data show that full-length repressor activator protein 1 (show FOSB Proteins) (Rap1 (show RABGEF1 Proteins)) binds to full-length telomeric repeat binding factor 2 (TRF2 (show TERF2 Proteins)) with high affinity and equimolar ratio.
C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer.
a detailed analysis of individual focal adhesion parameters identified focal adhesion size, sliding and intensity as primary targets of Rap1.
Nonsense mutations in the TERF2IP gene in familial melanoma: four families carried TERF2IP variants, which included nonsense mutations in both genes (p.Q320X and p.R364X, respectively).
Collectively the observations uncover a requirement for Rap1 in maintenance of lens epithelial phenotype and morphogenesis.
our results indicate that Rasa3 catalytic activity controls Rap1 activation and integrin signaling during megakaryocyte differentiation in mouse.
RASA3, inhibits platelet activation and provides a link between P2Y12 and activation of the RAP1 signaling pathway.
we summarize recent developments in understanding the small G protein (show RAC2 Proteins) RAP1 and its effector RASIP1 (show RASIP1 Proteins) as critical mediators of endothelial junction stabilization.
Molecular investigation revealed that deletion of RAP1 reduced upregulation of inflammatory cytokine (IL1A (show IL1A Proteins)), finely regulated the expression of angiogenic factor (VEGF (show VEGFA Proteins)), and antiangiogenic factor (PEDF (show SERPINF1 Proteins)), following injury for better corneal recovery.
Cdk5-mediated serine-phosphorylation of C3G may control Rap1 stability and activity
Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.
Rap1-Rac1 circuits potentiate platelet activation.
Rap1-deficient meiotic telomeres assemble the SUN1 (show SUN1 Proteins) nuclear membrane protein, attach to the nuclear envelope, and undergo bouquet formation.
HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion.
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22.
, TERF2-interacting telomeric protein 1
, TRF2-interacting telomeric RAP1 protein
, TRF2-interacting telomeric protein 1
, dopamine receptor interacting protein 5
, dopamine receptor-interacting protein 5
, repressor/activator protein 1 homolog
, telomeric repeat-binding factor 2-interacting protein 1
, TRF2-interacting telomeric protein Rap1