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p97 (show EIF4G2 ELISA Kits) negatively regulates NRF2 (show GABPA ELISA Kits) through the canonical pathway by extracting ubiquitylated NRF2 (show GABPA ELISA Kits) from the KEAP1 (show KEAP1 ELISA Kits)-CUL3 (show CUL3 ELISA Kits) E3 complex.
Regulation of substrate ubiquitination and polyubiquitination takes place through Rbx1 rotations.
High RBX1 expression was related to poor tumor differentiation, advanced TNM (show ODZ1 ELISA Kits) stage, and lymph node metastasis in non-small cell lung cancer.
Data show that melanoma antigen, family C, 2 protein (MAGE-C2) binds with RING-box protein 1 (Rbx1) and Cullin 1, and regulates cyclin E stability in melanoma cells.
ROC1 (show RIT1 ELISA Kits) has an important role in the malignant progression of bladder transitional cell carcinoma via the mTOR (show FRAP1 ELISA Kits)/DEPTOR (show DEPTOR ELISA Kits) pathway.
Nedd8 (show NEDD8 ELISA Kits)(Q40E) cannot induce the same structural effect on Cul1 (show CUL1 ELISA Kits)-Rbx1 as wild-type Nedd8 (show NEDD8 ELISA Kits).
RBX1 E3 ubiquitin protein expression responsible with multiple genetic mechanism in the development of head and neck cancer.
This work sheds new light on the roles of NEDD8 (show NEDD8 ELISA Kits) lysines on neddylation cascades and provides a dominant negative mutant for the study of neddylation and its biological functions.
These findings indicate that Rbx1 and Rbx2 (show RNF7 ELISA Kits) can both activate Cul5 (show CUL5 ELISA Kits)-Vif (show BTG1 ELISA Kits) E3 ligase in vitro, but they may undergo a more delicate selection mechanism in vivo.
upregulation of miR-194 can inhibit proliferation, migration, and invasion of GC cells, possibly by targeting RBX1. Aberrant expression of miR-194 and RBX1 is correlated to GC patient survival time.
Downregulation of Rbx1 caused accumulation of Emi1.
a model by which N-terminal cleavage of RBX1 impairs its activity and promotes susceptibility to ER stress induction.
Nrf2 regulates Cul3-Rbx1 by controlling regulation of expression and induction of Cul3-Rbx1
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
in vivo physiological function of RBX1 is to ensure cell proliferation by preventing p27 (show CDKN1B ELISA Kits) accumulation during the early stage of embryonic development
The SCF (show KITLG ELISA Kits)-complex gene expression has been characterized during bovine preimplantation development (show MTA2 ELISA Kits).
The axr6-101 phenotype is caused by the E716K substitution of the CUL1 protein, which is likely to affect its ability to bind to the C-terminal RING domain of RING-box 1 (RBX1).
oocyte maturation from pachytene exit and MPK-1 (show MAPK1 ELISA Kits) activation are redundantly controlled by the RBX-2-CUL-5 (show CUL5 ELISA Kits)- and RBX-1-CUL-2 (show CUL2 ELISA Kits)-based complexes.
BRWD3 functions as a Damage-specific DNA binding protein 1 (DDB1)- and CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-dependent binding of dCRY to CUL4-ROC1-DDB1-BRWD3, inducing ubiquitylation of dCRY
Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase.
Roc1b, Roc1a and Roc2 (show RIT2 ELISA Kits) proteins play nonredundant roles during development
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.
E3 ubiquitin-protein ligase RBX1
, RING box protein 1
, RING finger protein 75
, RING-box protein 1
, ZYP protein
, regulator of cullins 1
, ring-box protein 1
, ring-box 1
, hyperosmotic protein 21
, CG16982 gene product from transcript CG16982-RC
, Regulator of cullins 1a
, regulator of cullins 1a