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oocyte maturation from pachytene exit and MPK-1 (show MAPK1 ELISA Kits) activation are redundantly controlled by the RBX-2-CUL-5 (show CUL5 ELISA Kits)- and RBX-1-CUL-2 (show CUL2 ELISA Kits)-based complexes.
Downregulation of Rbx1 caused accumulation of Emi1.
the early or pre-induction nuclear export of INrf2 (show KEAP1 ELISA Kits) in response to antioxidants is controlled by tyrosine phosphorylation, whereas the nuclear export of Cul3 (show CUL3 ELISA Kits) and Rbx1 is controlled by INrf2 (show KEAP1 ELISA Kits), allowing normal activation or repression of Nrf2 (show NFE2L2 ELISA Kits)
a model by which N-terminal cleavage of RBX1 impairs its activity and promotes susceptibility to ER stress induction.
Nrf2 regulates Cul3-Rbx1 by controlling regulation of expression and induction of Cul3-Rbx1
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
prothymosin-alpha (show PTMA ELISA Kits)-mediated nuclear import of INrf2 (show KEAP1 ELISA Kits)/Cul3 (show CUL3 ELISA Kits) Rbx1 complex leads to ubiquitination and degradation of Nrf2 (show NFE2L2 ELISA Kits) inside the nucleus presumably to regulate nuclear level of Nrf2 (show NFE2L2 ELISA Kits) and rapidly switch off the activation of Nrf2 (show NFE2L2 ELISA Kits) downstream gene expression.
in vivo physiological function of RBX1 is to ensure cell proliferation by preventing p27 (show CDKN1B ELISA Kits) accumulation during the early stage of embryonic development
Data show that melanoma antigen, family C, 2 protein (MAGE-C2) binds with RING-box protein 1 (Rbx1) and Cullin 1, and regulates cyclin E stability in melanoma cells.
ROC1 (show RIT1 ELISA Kits) has an important role in the malignant progression of bladder transitional cell carcinoma via the mTOR (show FRAP1 ELISA Kits)/DEPTOR (show DEPTOR ELISA Kits) pathway.
Nedd8 (show NEDD8 ELISA Kits)(Q40E) cannot induce the same structural effect on Cul1 (show CUL1 ELISA Kits)-Rbx1 as wild-type Nedd8 (show NEDD8 ELISA Kits).
RBX1 E3 ubiquitin protein expression responsible with multiple genetic mechanism in the development of head and neck cancer.
This work sheds new light on the roles of NEDD8 (show NEDD8 ELISA Kits) lysines on neddylation cascades and provides a dominant negative mutant for the study of neddylation and its biological functions.
These findings indicate that Rbx1 and Rbx2 (show RNF7 ELISA Kits) can both activate Cul5 (show CUL5 ELISA Kits)-Vif (show BTG1 ELISA Kits) E3 ligase in vitro, but they may undergo a more delicate selection mechanism in vivo.
upregulation of miR-194 can inhibit proliferation, migration, and invasion of GC cells, possibly by targeting RBX1. Aberrant expression of miR-194 and RBX1 is correlated to GC patient survival time.
RBX1 expression level was associated with the proliferation of gastric cancer.
Studied the DNA-level mechanisms affecting KEAP1 (show KEAP1 ELISA Kits)/CUL3 (show CUL3 ELISA Kits)/RBX1 E3-ubiquitin ligase complex as a regulator of NRF2 (show GABPA ELISA Kits) levels in ovarian cancer.
eEF1A1 may mediate SAMHD1 turnover by targeting it to the proteosome for degradation through association with Cullin4A and Rbx1.
The SCF (show KITLG ELISA Kits)-complex gene expression has been characterized during bovine preimplantation development (show MTA2 ELISA Kits).
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.
E3 ubiquitin-protein ligase RBX1
, RING finger protein 75
, ring-box protein 1
, RING-box protein 1
, hyperosmotic protein 21
, RING box protein 1
, ZYP protein
, regulator of cullins 1