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Browse our anti-Retinoblastoma Binding Protein 8 (RBBP8) Antibodies

Full name:
anti-Retinoblastoma Binding Protein 8 Antibodies (RBBP8)
On www.antibodies-online.com are 96 Retinoblastoma Binding Protein 8 (RBBP8) Antibodies from 21 different suppliers available. Additionally we are shipping Retinoblastoma Binding Protein 8 Proteins (3) and many more products for this protein. A total of 111 Retinoblastoma Binding Protein 8 products are currently listed.
Synonyms:
9930104E21Rik, COM1, CTIP, DKFZp469K0714, JWDS, RBBP-8, RBBP8, RGD1308872, RIM, SAE2, SCKL2
list all antibodies Gene Name GeneID UniProt
RBBP8 5932 Q99708
RBBP8 225182 Q80YR6
RBBP8 291787 B1WC58

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Most Popular Reactivities for anti-Retinoblastoma Binding Protein 8 (RBBP8) Antibodies

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anti-Human Retinoblastoma Binding Protein 8 Antibodies:

anti-Mouse (Murine) Retinoblastoma Binding Protein 8 Antibodies:

anti-Rat (Rattus) Retinoblastoma Binding Protein 8 Antibodies:

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Top referenced anti-Retinoblastoma Binding Protein 8 Antibodies

  1. Human Monoclonal Retinoblastoma Binding Protein 8 Primary Antibody for ICC, IF - ABIN2668263 : Zhou, Caron, Legube, Paull: Quantitation of DNA double-strand break resection intermediates in human cells. in Nucleic acids research 2014 (PubMed)
    Show all 3 references for ABIN2668263

  2. Human Polyclonal Retinoblastoma Binding Protein 8 Primary Antibody for EIA, WB - ABIN783608 : Yu, Wu, Bowcock, Aronheim, Baer: The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. in The Journal of biological chemistry 1998 (PubMed)
    Show all 2 references for ABIN783608

  3. Human Polyclonal Retinoblastoma Binding Protein 8 Primary Antibody for WB - ABIN657950 : Kaidi, Weinert, Choudhary, Jackson: Human SIRT6 promotes DNA end resection through CtIP deacetylation. in Science (New York, N.Y.) 2010 (PubMed)
    Show all 2 references for ABIN657950

  4. Human Polyclonal Retinoblastoma Binding Protein 8 Primary Antibody for IHC, ELISA - ABIN1532780 : Fusco, Reymond, Zervos: Molecular cloning and characterization of a novel retinoblastoma-binding protein. in Genomics 1998 (PubMed)

  5. Dog (Canine) Polyclonal Retinoblastoma Binding Protein 8 Primary Antibody for WB - ABIN2784374 : Chen, Nievera, Lee, Wu: Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. in The Journal of biological chemistry 2008 (PubMed)

More Antibodies against Retinoblastoma Binding Protein 8 Interaction Partners

Xenopus laevis Retinoblastoma Binding Protein 8 (RBBP8) interaction partners

  1. MRN (Mre11 (show MRE11A Antibodies), Rad50 (show RAD50 Antibodies), and Nbs1 (show NLRP2 Antibodies)) complex, CtIP, and BRCA1 are required for both the removal of Top2 (show TOP2 Antibodies)-DNA adducts and the subsequent resection of Top2 (show TOP2 Antibodies)-adducted DSB ends.

  2. ATM (show ATM Antibodies) activity is required for an early step in resection, leading to ATR (show ATR Antibodies) activation, CtIP-T818 phosphorylation, and accumulation of CtIP on chromatin.

  3. By promoting CtIP-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 (show CDK1 Antibodies) inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.

Human Retinoblastoma Binding Protein 8 (RBBP8) interaction partners

  1. Homozygous RBBP8 mutation is associated with microcephaly, intellectual disability, short stature and brachydactyly.

  2. USP4 (show USP4 Antibodies) cooperates with CtIP in DNA double-strand break end resection.

  3. CtIP is a DNA damage response protein at the intersection of DNA metabolism. (Review)

  4. Data show that ubiquitin E2 enzymes UBE2D1 (show UBE2D1 Antibodies)/2/3 and E3 ligase RNF138 (show RNF138 Antibodies) accumulate at DNA-damage sites and act at early resection stages by promoting CtIP protein ubiquitylation and accrual.

  5. BRCA1 and CtIP contribute to DSB resection by recruiting Dna2 (show DNA2 Antibodies) to damage sites, thus ensuring the robust DSB resection necessary for efficient homologous recombination.

  6. The CtIP 3'UTR (show UTS2R Antibodies) is directly targeted by miR (show MLXIP Antibodies)-19a and miR (show MLXIP Antibodies)-19b.

  7. CtIP interacts with Cdh1 (show CDH1 Antibodies) through a conserved KEN (show PCNT Antibodies) box, mutation of which impedes ubiquitylation and downregulation of CtIP both during G1 and after DNA damage in G2.

  8. Possible association of SOX-17 (show SOX17 Antibodies) and RBBP8 with brain arteriovenous malformations, genes involved in cell cycle progression, deserves further investigation

  9. findings provide strong evidence that CtIP is continuously recruited to DSBs downstream of both the initiation and extension step of resection

  10. Data indicate that FANCD2 (show FANCD2 Antibodies) primes CtIP-dependent resection during HR after ICL induction but that CtIP helps prevent illegitimate recombination in FA cells.

Mouse (Murine) Retinoblastoma Binding Protein 8 (RBBP8) interaction partners

  1. work therefore ascribes novel roles for BRCA1 (show BRCA1 Antibodies) and CtIP in end-processing and fusion reactions at uncapped telomeres

  2. Data indicate that loss of the CtIP-BRCA1 interaction does not detectably affect resection, maintenance of genomic stability or viability.

  3. The phospho-dependent BRCA1 (show BRCA1 Antibodies)-CtIP interaction is not essential for HDR (show GATA3 Antibodies)-mediated DSB repair or for tumor suppression.

  4. CtIP contributes to the metabolism of DNA ends during DNA double-strand breaks repair in B lymphocytes.

  5. CtIP-mediated alt-NHEJ has a primary role in translocation formation.

  6. CtIP binds to switch-region DNA and plays a physiological role in microhomology-mediated end joining in a C-NHEJ-proficient environment.

  7. the histone protein H2AX (show H2AFX Antibodies) prevents nucleases other than Artemis (show DCLRE1C Antibodies) from processing hairpin-sealed coding ends; in the absence of H2AX (show H2AFX Antibodies), CtIP can efficiently promote the hairpin opening and resection of DNA ends generated by RAG cleavage

  8. CtIP counteracts Rb-mediated G(1) restraint.

  9. Rbbp8 is shown to be upregulated in response to X-irradiation in the AML (show RUNX1 Antibodies) sensitive CBA strain but not AML (show RUNX1 Antibodies) resistant C57BL/6 strain

  10. CtiP activates its own and cyclin D promoters via the E2F (show E2F1 Antibodies)/RB pathway during G1/S progression.

Retinoblastoma Binding Protein 8 (RBBP8) Antigen Profile

Antigen Summary

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Alternative names and synonyms associated with Retinoblastoma Binding Protein 8 (RBBP8)

  • retinoblastoma binding protein 8 (RBBP8) antibody
  • retinoblastoma binding protein 8 (rbbp8) antibody
  • retinoblastoma binding protein 8 (LOC100354690) antibody
  • retinoblastoma binding protein 8 (Rbbp8) antibody
  • 9930104E21Rik antibody
  • COM1 antibody
  • CTIP antibody
  • DKFZp469K0714 antibody
  • JWDS antibody
  • RBBP-8 antibody
  • RBBP8 antibody
  • RGD1308872 antibody
  • RIM antibody
  • SAE2 antibody
  • SCKL2 antibody

Protein level used designations for RBBP8

retinoblastoma binding protein 8 , CtBP-interacting protein , DNA endonuclease RBBP8 , ctBP-interacting protein , retinoblastoma-binding protein 8 , sporulation in the absence of SPO11 protein 2 homolog , retinoblastoma-binding protein 8-like , CTBP-interacting protein , RBBP-8

GENE ID SPECIES
421071 Gallus gallus
444252 Xenopus laevis
455333 Pan troglodytes
512977 Bos taurus
677718 Macaca mulatta
100174689 Pongo abelii
100354690 Oryctolagus cuniculus
100380142 Xenopus (Silurana) tropicalis
100399729 Callithrix jacchus
100437097 Pongo abelii
100526778 Papio anubis
100604424 Nomascus leucogenys
5932 Homo sapiens
225182 Mus musculus
291787 Rattus norvegicus
480175 Canis lupus familiaris
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