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anti-Human SMAD2 Antibodies:
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Human Monoclonal SMAD2 Primary Antibody for IF, IP - ABIN968106
Babu, Jeganathan, Baker, Wu, Kang-Decker, van Deursen: Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. in The Journal of cell biology 2003
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Human Monoclonal SMAD2 Primary Antibody for IF, IP - ABIN968105
Chen, Waters, Salmon, Murray: Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. in Science (New York, N.Y.) 1996
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Human Polyclonal SMAD2 Primary Antibody for WB - ABIN2801941
Liu, Pouponnot, Massagué: Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. in Genes & development 1998
Show all 3 Pubmed References
Human Monoclonal SMAD2 Primary Antibody for ICC, FACS - ABIN969401
Wendt, Smith, Schiemann: p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. in The Journal of biological chemistry 2009
Show all 2 Pubmed References
Human Polyclonal SMAD2 Primary Antibody for ELISA, WB - ABIN257079
Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. in Cell 1996
Human Polyclonal SMAD2 Primary Antibody for IHC (p), IHC - ABIN316295
Lee, Lee, Bae, Jung: Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. in Histochemistry and cell biology 2013
Human Polyclonal SMAD2 Primary Antibody for ICC, IF - ABIN4354659
Samanta, Gilkes, Chaturvedi, Xiang, Semenza: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. in Proceedings of the National Academy of Sciences of the United States of America 2014
Human Polyclonal SMAD2 Primary Antibody for IHC, IHC (p) - ABIN4354665
Yamamura, Matsumura, Mandai, Huang, Oura, Baba, Hamanishi, Yamaguchi, Kang, Okamoto, Abiko, Mori, Murphy, Konishi: The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer. in International journal of cancer 2011
Human Polyclonal SMAD2 Primary Antibody for WB - ABIN1842518
Song, Thalacker, Nilsen-Hamilton: Synergistic and multidimensional regulation of plasminogen activator inhibitor type 1 expression by transforming growth factor type ? and epidermal growth factor. in The Journal of biological chemistry 2012
Human Monoclonal SMAD2 Primary Antibody for IF, IHC (p) - ABIN517619
Talvinen, Tuikkala, Nykänen, Nieminen, Anttinen, Nevalainen, Hurme, Kuopio, Kronqvist: Altered expression of p120catenin predicts poor outcome in invasive breast cancer. in Journal of cancer research and clinical oncology 2010
The non-Smad (show SMAD1 Antibodies) JNK (show MAPK8 Antibodies) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (show SMAD1 Antibodies) pathway, and this nuclear movement is associated with Smad (show SMAD1 Antibodies) signal transduction toward the nucleus.
The results of this study found that Bptf (show BPTF Antibodies) and TGF-beta (show TGFB1 Antibodies)/Smad2 mediate nucleosome remodeling to regulate wnt8a (show WNT8A Antibodies) expression and hence neural posteriorization.
Smad2 and Eomesodermin (show EOMES Antibodies) a (Eomesa (show EOMES Antibodies)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (show EOMES Antibodies) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
CRT (show SLC6A8 Antibodies) regulates TGF-beta1 (show TGFB1 Antibodies)-induced-EMT (show ITK Antibodies) through modulating Smad (show SMAD1 Antibodies) signaling
P311 (show C5orf13 Antibodies) is a novel TGFbeta1 (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
human epidermal growth factor receptor (show EGFR Antibodies) 2 (HER-2 (show ERBB2 Antibodies)) levels, were correlated well with TSP50 (show PRSS50 Antibodies)/p-Samd2 (show SARM1 Antibodies)/3 and TSP50 (show PRSS50 Antibodies)/p27 (show PAK2 Antibodies) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50 (show PRSS50 Antibodies)-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
IL-17 (show IL17A Antibodies) can induce A549 alveolar epithelial cells to undergo epithelial-mesenchymal transition via the TGF-beta1 (show TGFB1 Antibodies) mediated Smad2/3 and ERK1/2 (show MAPK1/3 Antibodies) activation
a critical role for miR (show MLXIP Antibodies)-503-3p in induction of breast cancer EMT (show ITK Antibodies)
Nuclear localization of Smad2 was reduced in TGFbeta (show TGFB1 Antibodies)-1-stimulated primary tubular epithelial cells. Changes in nuclear Smad2 correlated with a reduced expression of the pro-fibrotic factor CTGF (show CTGF Antibodies). Transient downregulation of Smad2 interfered with TGFbeta (show TGFB1 Antibodies)-1-induced CTGF (show CTGF Antibodies) synthesis.
Low SMAD2 expression is associated with progression of hepatic fibrosis.
In order to study the translation between mouse model and patients, we evaluated the signature of phosphorylated Sma- and Mad-related protein 2 (pSmad2), as molecular marker of TGF-beta/activin activity, in the kidneys of streptozotocin (STZ)-treated mice compared to that of type 1 diabetes (T1D) patients.
SMAD2/SMAD3 (show SMAD3 Antibodies) signaling by bone morphogenetic proteins causes disproportionate induction of HAS2 (show HAS2 Antibodies) expression and hyaluronan production in immortalized human granulosa cells.
miR (show MLXIP Antibodies)-27a contributed to cell proliferation and invasion by inhibiting TGF-beta (show TGFB1 Antibodies)-induced cell cycle arrest. These results suggest that miR (show MLXIP Antibodies)-27a may function as an oncogene (show RAB1A Antibodies) by regulating SMAD2 and SMAD4 (show SMAD4 Antibodies) in lung cancer.
Grg4 (show TLE4 Antibodies) occupancy at the Xnr1 (show NODAL Antibodies) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 (show TLE4 Antibodies) from FoxH1 (show FOXH1 Antibodies) at the Xnr1 (show NODAL Antibodies) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (show TCF3 Antibodies) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (show GDF11 Antibodies) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
Activin A (show INHBA Antibodies) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (show NANOG Antibodies) and OCT4 (show POU5F1 Antibodies),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (show NANOG Antibodies)/OCT4 (show POU5F1 Antibodies) expression.
the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (show TPM1 Antibodies), as a model of immature Leydig cells.
Lnc-LFAR1 binds directly to Smad2/3 and promotes transcription of TGFbeta (show TGFB1 Antibodies), Smad2, Smad3 (show SMAD3 Antibodies), Notch2 (show NOTCH2 Antibodies) and Notch3 (show NOTCH3 Antibodies) which, in turn, results in TGFbeta (show TGFB1 Antibodies) and Notch (show NOTCH1 Antibodies) pathway activation.
the levels of Smad2/3, P-Smad2/3 expressions were decreased, while the level of Smad7 (show SMAD7 Antibodies) expression was increased after treatment with osthole.
These findings implicate TGF-beta (show TGFB1 Antibodies)-Smad2/3 signaling in activated tissue-resident cardiac fibroblasts as principal mediators of the fibrotic response.
selective inhibition of SMAD3 (show SMAD3 Antibodies) or CCT6A (show CCT6A Antibodies) efficiently suppresses TGF-beta (show TGFB1 Antibodies)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (show TGFB1 Antibodies) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (show TGFB1 Antibodies) for non-small-cell lung carcinoma.
results demonstrate that TGF-beta1 (show TGFB1 Antibodies)-induced autophagy links beta-catenin (show CTNNB1 Antibodies) and Smad (show SMAD1 Antibodies) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (show CTNNB1 Antibodies)/p-Smad2/ILK (show ILK Antibodies) pathway.
These results suggest that Nedd9 (show NEDD9 Antibodies) is a Smad2/3 target gene implicated in RANKL (show TNFSF11 Antibodies)-induced osteoclastogenesis.
In conclusion, TGF-beta (show TGFB1 Antibodies) signaling pathway may influence liver fibrosis by incorporating with YB-1 (show YBX1 Antibodies), indicating that YB-1 (show YBX1 Antibodies) could be a potential target for therapies against liver fibrosis.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
SMAD, mothers against DPP homolog 2
, MAD (mothers against decapentaplegic, Drosophila) homolog 2
, SMA- and MAD-related protein 2
, SMAD 2
, SMAD family member 2
, mothers against DPP homolog 2
, mothers against decapentaplegic homolog 2
, MAD homolog 2
, Sma- and Mad-related protein 2
, mother against DPP homolog 2
, mothers against decapentaplegic-like 2
, Smad 2
, mad-related protein 2