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Browse our anti-SMAD2 (SMAD2) Antibodies

Full name:
anti-SMAD, Mothers Against DPP Homolog 2 Antibodies (SMAD2)
On are 404 SMAD, Mothers Against DPP Homolog 2 (SMAD2) Antibodies from 29 different suppliers available. Additionally we are shipping SMAD2 Kits (29) and SMAD2 Proteins (27) and many more products for this protein. A total of 481 SMAD2 products are currently listed.
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2
list all antibodies Gene Name GeneID UniProt
SMAD2 4087 Q15796
SMAD2 17126 Q62432
SMAD2 29357 O70436

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Top referenced anti-SMAD2 Antibodies

  1. Human Polyclonal SMAD2 Primary Antibody for EIA, WB - ABIN401419 : Yang, Huang, Chen, Lin, Chen: Leptin augments myofibroblastic conversion and fibrogenic activity of human peritoneal mesothelial cells: a functional implication for peritoneal fibrosis. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007 (PubMed)
    Show all 6 references for ABIN401419

  2. Human Polyclonal SMAD2 Primary Antibody for IF, IHC - ABIN1532651 : Zhang, Feng, We, Derynck: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. in Nature 1996 (PubMed)
    Show all 2 references for ABIN1532651

  3. Human Polyclonal SMAD2 Primary Antibody for ELISA, WB - ABIN1532649 : Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. in Cell 1996 (PubMed)
    Show all 2 references for ABIN1532649

  4. Chicken Polyclonal SMAD2 Primary Antibody for WB - ABIN2780721 : Zheng, Zugates, Lu, Shi, Bai, Lee: Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons. in The EMBO journal 2006 (PubMed)

  5. Human Polyclonal SMAD2 Primary Antibody for FACS, IF - ABIN391545 : Funaba, Zimmerman, Mathews: Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. in The Journal of biological chemistry 2002 (PubMed)

  6. Chicken Polyclonal SMAD2 Primary Antibody for IHC, WB - ABIN2779412 : Antonson, Jakobsson, Almlöf, Guldevall, Steffensen, Gustafsson: RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. in The Journal of biological chemistry 2008 (PubMed)

More Antibodies against SMAD2 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. The results of this study found that Bptf (show BPTF Antibodies) and TGF-beta (show TGFB1 Antibodies)/Smad2 mediate nucleosome remodeling to regulate wnt8a (show WNT8A Antibodies) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (show EOMES Antibodies) a (Eomesa (show EOMES Antibodies)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (show EOMES Antibodies) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. MiR (show MLXIP Antibodies)-425 functions as an oncogene (show RAB1A Antibodies) by targeting the 3'-UTR (show UTS2R Antibodies) of SMAD2 in esophageal squamous cell carcinoma.

  2. The present study thus proposed SEB (show SETBP1 Antibodies) as an agent able to significantly reduce Smad2/3 expression in colon cancer cells, provoking moderate TGFb (show TGFB1 Antibodies) growth signaling and the reduction of tumor cell proliferation.

  3. correlation between TGFb1 (show TGFB1 Antibodies) and pSmad2 as well as between HtrA1 (show HTRA1 Antibodies) and TGFb1 (show TGFB1 Antibodies) and the very significant increase of Ki67 (show MKI67 Antibodies) in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 (show HTRA1 Antibodies) in the pathogenesis of endometriosis.

  4. Up-regulation of smad2 is associated with endometrial cancer.

  5. SMAD2 mutations are associated with arterial aneurysms and dissections

  6. data suggest that TGF-beta1 (show TGFB1 Antibodies) enhances IGFBP7 (show IGFBP7 Antibodies) via Smad2/4 pathways, and that IGFBP7 (show IGFBP7 Antibodies) might be involved in the TGF-beta1 (show TGFB1 Antibodies)-induced tubular injury in DN.

  7. Studies demonstrated that MUC1 (show MUC1 Antibodies)-mediated JNK (show MAPK8 Antibodies) activation not only enhances the phosphorylation of Smad2 C-terminal at Ser (show SIGLEC1 Antibodies)-465/467 site (Smad2C) through TGF-beta (show TGFB1 Antibodies)/TbetaRI (show TGFBR1 Antibodies), but also enhances the phosphorylation of Smad2 linker region at Ser (show SIGLEC1 Antibodies)-245/250/255 site.

  8. Different signaling pathways are involved in osteitis in CRS (show CARS Antibodies) and are activated by the TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling pathway in CRSwNP versus the TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies)-independent signaling pathway in CRSsNP.

  9. smad2 and Erk (show EPHB2 Antibodies)/Akt (show AKT1 Antibodies) have roles in TGF-beta1 (show TGFB1 Antibodies)-induced apoptosis in human gingival epithelial cells

  10. Report inhibition of colorectal cancer stem cell survival and invasive potential by hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-140-5p mediated suppression of Smad2 and autophagy.

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. E2a (show TCF3 Antibodies) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  2. GDF11 (show GDF11 Antibodies) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  3. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

  2. Smad2 and Smad3 (show SMAD3 Antibodies) oppositely modify STAT3 (show STAT3 Antibodies)-induced transcription of IL-17A (show IL17A Antibodies) and retinoic acid receptor (show RARA Antibodies)-related orphan nuclear receptor (show NR1D1 Antibodies), RORgammat encoded by Rorc (show RORC Antibodies), by acting as a co-activator and co-repressor of STAT3 (show STAT3 Antibodies), respectively.

  3. Endoplasmic reticulum stress in hepatic stellar cells promotes liver fibrosis by inducing over expression of SMAD2.

  4. pSmad3L-Ser (show SIGLEC1 Antibodies) signalling correlates with carcinogenesis of colon tumors and this work supports the hypothesis that pSmad2/3L-Thr (show TRH Antibodies) immunostaining-positive cells are cancer stem cells.

  5. These results suggest that TGF-beta regulates RANKL-induced osteoclastogenesis through reciprocal cooperation between Smad2/3 and c-Fos.

  6. Treatment with geniposide almost completely blocked the phosphorylation of Smad2/3, extracellular signal-regulated kinase (ERK (show EPHB2 Antibodies)) and Akt (show AKT1 Antibodies) in AML12 cells.

  7. Deficiency of MKP5 (show DUSP10 Antibodies) resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 (show DUSP10 Antibodies) critically controls inflammation in white adipose tissue and the development of metabolic disorders

  8. Data show that the Notch (show NOTCH1 Antibodies) pathway is involved in kidney fibrosis through activation of transforming growth factor beta (TGF-beta)/Smad (show SMAD1 Antibodies) proteins 2/3 (Smad2/3) signaling.

  9. Studies indicate that Nodal/Smad2-dependent signals govern initial proximal-distal polarity and formation of the anterior visceral endoderm (AVE).

  10. In conclusion, this study identifies opposing roles for Smad2 and Smad3 (show SMAD3 Antibodies) in peritoneal dialysis-associated peritoneal fibrosis

SMAD2 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2) antibody
  • SMAD family member 2 (smad2) antibody
  • MAD homolog 2 (Drosophila) (smad2) antibody
  • SMAD family member 2 (Smad2) antibody
  • 7120426M23Rik antibody
  • fj43c06 antibody
  • hMAD-2 antibody
  • hSMAD2 antibody
  • JV18 antibody
  • JV18-1 antibody
  • Madh2 antibody
  • Madr2 antibody
  • mMad2 antibody
  • Smad-2 antibody
  • wu:fj43c06 antibody
  • Xmad2 antibody
  • XSmad2 antibody

Protein level used designations for SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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