Browse our anti-SMAD2 (SMAD2) Antibodies

Full name:
anti-SMAD, Mothers Against DPP Homolog 2 Antibodies (SMAD2)
On www.antibodies-online.com are 414 SMAD, Mothers Against DPP Homolog 2 (SMAD2) Antibodies from 31 different suppliers available. Additionally we are shipping SMAD2 Kits (40) and SMAD2 Proteins (28) and many more products for this protein. A total of 502 SMAD2 products are currently listed.
Synonyms:
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2
list all antibodies Gene Name GeneID UniProt
SMAD2 4087 Q15796
SMAD2 17126 Q62432
SMAD2 29357 O70436

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Top referenced anti-SMAD2 Antibodies

  1. Human Polyclonal SMAD2 Primary Antibody for EIA, WB - ABIN401418 : Liapis, Mylona, Alexandrou, Giannopoulou, Nikolaou, Markaki, Keramopoulos, Nakopoulou: Effect of the different phosphorylated Smad2 protein localizations on the invasive breast carcinoma phenotype. in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2007 (PubMed)
    Show all 6 references for 401418

  2. Human Polyclonal SMAD2 Primary Antibody for ELISA, WB - ABIN1532650 : Zhang, Feng, We, Derynck: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. in Nature 1996 (PubMed)
    Show all 2 references for 1532650

  3. Human Polyclonal SMAD2 Primary Antibody for IF, ELISA - ABIN1531629 : Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. in Cell 1996 (PubMed)
    Show all 2 references for 1531629

  4. Human Polyclonal SMAD2 Primary Antibody for IF, WB - ABIN391546 : Funaba, Zimmerman, Mathews: Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. in The Journal of biological chemistry 2002 (PubMed)

  5. Cow (Bovine) Polyclonal SMAD2 Primary Antibody for WB - ABIN2780721 : Zheng, Zugates, Lu, Shi, Bai, Lee: Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons. in The EMBO journal 2006 (PubMed)

  6. Cow (Bovine) Polyclonal SMAD2 Primary Antibody for IHC, WB - ABIN2779412 : Antonson, Jakobsson, Almlöf, Guldevall, Steffensen, Gustafsson: RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. in The Journal of biological chemistry 2008 (PubMed)

More Antibodies against SMAD2 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. The results of this study found that Bptf (show BPTF Antibodies) and TGF-beta (show TGFB1 Antibodies)/Smad2 mediate nucleosome remodeling to regulate wnt8a (show WNT8A Antibodies) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (show EOMES Antibodies) a (Eomesa (show EOMES Antibodies)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (show EOMES Antibodies) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. In response to TGF-beta (show TGFB1 Antibodies), RASSF1A (show RASSF1 Antibodies) is recruited to TGF-beta (show TGFB1 Antibodies) receptor I and targeted for degradation by the co-recruited E3 ubiquitin ligase (show MUL1 Antibodies) ITCH. RASSF1A (show RASSF1 Antibodies) degradation is necessary to permit Hippo pathway effector YAP1 (show YAP1 Antibodies) association with SMADs and subsequent nuclear translocation of receptor-activated SMAD2.

  2. Smad2 is a key scaffold, allowing RIN1 (show RIN1 Antibodies) to act as a GTP (show AK3 Antibodies) exchange factor for MFN2 (show MFN2 Antibodies)-GTPase (show RACGAP1 Antibodies) activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.

  3. Ang (show ANG Antibodies) down-regulate the expression of Col (show HDAC1 Antibodies)-I, alpha-SMA (show SMN1 Antibodies) and TGF-beta1 (show TGFB1 Antibodies)/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition.

  4. The nuclear importin (show KPNA4 Antibodies) IPO5 (show IPO5 Antibodies) was identified as a novel interacting protein of SMAD1 (show GARS Antibodies). Overexpression of IPO5 (show IPO5 Antibodies) in various cell lines specifically increases nuclear localization of BMP receptor (show BMPR1A Antibodies)-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 (show IPO5 Antibodies) and BMP but not TGF-beta (show TGFB1 Antibodies) R-SMADs.

  5. Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (show TGFB1 Antibodies)/Smad2 signaling pathway, but not Smad1 (show GARS Antibodies)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.

  6. the findings show that TIEG1 (show KLF10 Antibodies) is highly expressed in human keloids and that it directly binds and represses Smad7 (show SMAD7 Antibodies) promoter-mediated activation of TGF-beta (show TGFB1 Antibodies)/Smad2 signaling

  7. A significant association was found between the low expression of inhibitory protein SMAD-7 (show SMAD7 Antibodies) and both zeta-chain-associated protein kinase (show CDK7 Antibodies) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (show GARS Antibodies)/8 and lower SMAD-4 (show SMAD4 Antibodies) expression in chronic lymphocytic leukemia cells

  8. High expression of SMAD2 is associated with colorectal carcinoma.

  9. this study shows that tolfenamic acid inhibits growth of colon cancer cells through downregulation of Smad2

  10. overexpression of miR29b markedly reduced the expression levels of COL1A1 (show COL1A1 Antibodies) and alphaSMA (show ACTA2 Antibodies), and decreased the expression and nuclear accumulation of pSmad2/3.

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. Grg4 (show TLE4 Antibodies) occupancy at the Xnr1 (show NODAL Antibodies) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 (show TLE4 Antibodies) from FoxH1 (show FOXH1 Antibodies) at the Xnr1 (show NODAL Antibodies) enhancer, an essential feature of the transcriptional switch mechanism.

  2. E2a (show TCF3 Antibodies) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  3. GDF11 (show GDF11 Antibodies) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  4. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Pig (Porcine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. Activin A (show INHBA Antibodies) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (show NANOG Antibodies) and OCT4 (show POU5F1 Antibodies),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (show NANOG Antibodies)/OCT4 (show POU5F1 Antibodies) expression.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. These results suggest that Nedd9 (show NEDD9 Antibodies) is a Smad2/3 target gene implicated in RANKL (show TNFSF11 Antibodies)-induced osteoclastogenesis.

  2. In conclusion, TGF-beta (show TGFB1 Antibodies) signaling pathway may influence liver fibrosis by incorporating with YB-1 (show YBX1 Antibodies), indicating that YB-1 (show YBX1 Antibodies) could be a potential target for therapies against liver fibrosis.

  3. miR (show MLXIP Antibodies)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (show TGFB1 Antibodies) receptor 1 and SMAD2.

  4. hese studies revealed that Smad2 plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (show IHH Antibodies) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  5. This study found evidence of increased leukocyte phosphorylated-Smad2/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (show TGFB1 Antibodies).

  6. Data show that muscle-specific (show EIF3K Antibodies) Smad (show SMAD1 Antibodies) proteins Smad2/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  7. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (show WNT2 Antibodies) pathway, and inhibition of Smad2/3 signaling and Shh (show SHH Antibodies) pathways.

  8. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

  9. Smad2 and Smad3 (show SMAD3 Antibodies) oppositely modify STAT3 (show STAT3 Antibodies)-induced transcription of IL-17A (show IL17A Antibodies) and retinoic acid receptor (show RARA Antibodies)-related orphan nuclear receptor (show NR1D1 Antibodies), RORgammat encoded by Rorc (show RORC Antibodies), by acting as a co-activator and co-repressor of STAT3 (show STAT3 Antibodies), respectively.

  10. Endoplasmic reticulum stress in hepatic stellar cells promotes liver fibrosis by inducing over expression of SMAD2.

SMAD2 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2) antibody
  • SMAD family member 2 (smad2) antibody
  • MAD homolog 2 (Drosophila) (smad2) antibody
  • SMAD family member 2 (Smad2) antibody
  • 7120426M23Rik antibody
  • fj43c06 antibody
  • hMAD-2 antibody
  • hSMAD2 antibody
  • JV18 antibody
  • JV18-1 antibody
  • Madh2 antibody
  • Madr2 antibody
  • mMad2 antibody
  • Smad-2 antibody
  • wu:fj43c06 antibody
  • Xmad2 antibody
  • XSmad2 antibody

Protein level used designations for SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

GENE ID SPECIES
100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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