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Browse our TPP1 Proteins (TPP1)

Full name:
Tripeptidyl Peptidase I Proteins (TPP1)
On are 12 Tripeptidyl Peptidase I (TPP1) Proteins from 5 different suppliers available. Additionally we are shipping TPP1 Antibodies (84) and TPP1 Kits (13) and many more products for this protein. A total of 118 TPP1 products are currently listed.
Cln2, fa01b09, im:7149243, LPIC, TPP-1, TPP-I, wu:fa01b09
list all proteins Gene Name GeneID UniProt
TPP1 1200 O14773
TPP1 83534 Q9EQV6
TPP1 12751 O89023

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TPP1 Proteins (TPP1) by Origin

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Top referenced TPP1 Proteins

  1. Human TPP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005756 : OConnor, Safari, Xin, Liu, Songyang: A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)

More Proteins for TPP1 Interaction Partners

Human Tripeptidyl Peptidase I (TPP1) interaction partners

  1. The conservation between fission yeast Tpz1-Pot1 (show POT1 Proteins) and human TPP1-POT1 (show POT1 Proteins) interactions resulted in mapping a human melanoma-associated (show ZNF654 Proteins) POT1 (show POT1 Proteins) mutation (A532P) to the TPP1-POT1 (show POT1 Proteins) interface.

  2. that the insertion in fingers domain can mediate enzyme processivity and telomerase recruitment to telomeres in a TPP1-dependent manner

  3. these data provide a molecular basis by which POT1 (show POT1 Proteins)-TPP1 increases the processivity of telomerase15. Further, we show that this increased processivity may arise from the dynamic sliding of POT1 (show POT1 Proteins)-TPP1 that induces fast translocation of telomerase.

  4. Mutations have been identified in the TEN-domain of TERT (show TERT Proteins) that disrupt the interaction of telomerase with TPP1 in vivo and in vitro but have very little effect on the catalytic activity of telomerase.

  5. TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7 (show USP7 Proteins).

  6. TPP1(CLN2) mutation is associated with neuronal ceroid lipofuscinosis (show CLN6 Proteins).

  7. TPP1 provides an essential step of telomerase activation as well as feedback regulation of telomerase by telomere length, which is necessary to determine the appropriate telomere length set point in human embryonic stem cells

  8. TPP1 has recently emerged as a primary contributor in protecting telomere DNA and in recruiting telomerase to the telomere ends. (Review)

  9. To our knowledge, our results bring the first evidence of a mechanism that links TPP-1 deficiency and oxidative stress-induced (show SQSTM1 Proteins) changes in mitochondrial morphology.

  10. Elevated expression of TPP1 in human colorectal cancer cells could protect telomere from DNA damage and confer radioresistance.

Mouse (Murine) Tripeptidyl Peptidase I (TPP1) interaction partners

  1. telomeres are protected from hyper-resection through the repression of the ATM (show ATM Proteins) and ATR kinases by TRF2 (show TERF2 Proteins) and TPP1-bound POT1a (show POT1 Proteins)/b, respectively.

  2. Rssults suggested that CLN2, CLN3 (show CLN3 Proteins) and CLN5 (show CLN5 Proteins) genes may play an important role in early embryonal neurogenesis.

  3. demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 (show TINF2 Proteins) phenocopy the POT1a (show POT1 Proteins),b knockout setting without showing additional phenotypes

  4. Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor alpha (show PPARA Proteins) and may have implications in late infantile Batten disease therapy

  5. TPPI activity becomes crucial for the neuronal functions later in development.

  6. Telomere protection by TPP1/POT1 (show POT1 Proteins) requires tethering to TIN2 (show TINF2 Proteins).

  7. TPP1 protects telomere integrity and regulates telomerase recruitment to telomeres, thereby preventing early occurrence of degenerative skin pathologies.

  8. TPP1 deletion resulted in the release of POT1a (show POT1 Proteins) and POT1b from chromatin and loss of these proteins from telomeres, indicating that TPP1 is required for the telomere association of POT1a (show POT1 Proteins) and POT1b but not for their stability.

  9. Lysosomal degradation of cholecystokinin (show CCK Proteins)-(29-33)-amide in mouse brain is dependent on this enzyme: implications for the degradation and storage of peptides in classical late-infantile neuronal ceroid lipofuscinosis (show CLN6 Proteins) (tripeptidyl peptidase-I)

  10. TPP-I is the predominant proteolytic enzyme responsible for the intracellular degradation of neuromedin B

TPP1 Protein Profile

Protein Summary

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Alternative names and synonyms associated with TPP1

  • tripeptidyl peptidase I (tpp1)
  • tripeptidyl-peptidase 1 (NAEGRDRAFT_78259)
  • tripeptidyl-peptidase 1 (MCYG_00184)
  • tripeptidyl-peptidase 1 (MGYG_05881)
  • tripeptidyl-peptidase 1 (MGYG_00757)
  • tripeptidyl peptidase I (TPP1)
  • tripeptidyl peptidase I (Tpp1)
  • Cln2 protein
  • fa01b09 protein
  • im:7149243 protein
  • LPIC protein
  • TPP-1 protein
  • TPP-I protein
  • wu:fa01b09 protein

Protein level used designations for Tripeptidyl Peptidase I Proteins (TPP1)

ceroid-lipofuscinosis, neuronal 2 , tripeptidyl-peptidase 1 , cell growth-inhibiting gene 1 protein , growth-inhibiting protein 1 , lysosomal pepstatin insensitive protease , tripeptidyl aminopeptidase , LPIC , TPP-1 , TPP-I , lysosomal pepstatin-insensitive protease , tripeptidyl peptidase 1 , tripeptidyl-peptidase I , tripeptidyl peptidase-I

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8862382 Naegleria gruberi strain NEG-M
9230210 Arthroderma otae CBS 113480
10026584 Arthroderma gypseum CBS 118893
10031989 Arthroderma gypseum CBS 118893
100195058 Salmo salar
1200 Homo sapiens
485337 Canis lupus familiaris
515575 Bos taurus
83534 Rattus norvegicus
12751 Mus musculus
425576 Gallus gallus
100356773 Oryctolagus cuniculus
100733945 Cavia porcellus
450999 Pan troglodytes
100440001 Pongo abelii
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