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Human Polyclonal GLRX5 Primary Antibody for IF (p), IHC (p) - ABIN1715024
Rychtarcikova, Lettlova, Tomkova, Korenkova, Langerova, Simonova, Zjablovskaja, Alberich-Jorda, Neuzil, Truksa: Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. in Oncotarget 2016
Cow (Bovine) Polyclonal GLRX5 Primary Antibody for WB - ABIN2786968
Camaschella, Campanella, De Falco, Boschetto, Merlini, Silvestri, Levi, Iolascon: The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload. in Blood 2007
Patients with GLRX5-associated variant nonketotic hyperglycemia had normal development with childhood-onset spastic paraplegia, spinal lesion, and optic atrophy.
crystal structure of GLRX5 revealed a tetrameric organization with the [2Fe-2S] clusters buried in the interior and shielded from the solvent by the conserved beta1-alpha2 loop
Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
No GLRX5 mutations were found among sixty CSA probands examined
Mutations in GLRX5 is associated with sideroblastic-like microcytic anemia and iron overload
Grx5 is an important determinant of osteoblast apoptosis and acts via a molecular pathway that involves regulation of ROS (show ROS1 Antibodies) production, cardiolipin oxidation, caspase (show CASP3 Antibodies) activity, Fe-S cluster formation, and MnSOD (show SOD2 Antibodies) activity.
the hypochromic anaemia in shiraz (sir) zebrafish mutants is caused by deficiency of glutaredoxin 5 (grx5), a gene required in yeast for Fe-S cluster assembly
This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia.
glutaredoxin 5 homolog
, glutaredoxin-related protein 5, mitochondrial
, monothiol glutaredoxin-5