Browse our Glutaredoxin 1 Proteins (GRX1)

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Glutaredoxin 1 Proteins (GRX1)
On www.antibodies-online.com are 28 Glutaredoxin 1 (GRX1) Proteins from 11 different suppliers available. Additionally we are shipping Glutaredoxin 1 Antibodies (52) and Glutaredoxin 1 Kits (15) and many more products for this protein. A total of 99 Glutaredoxin 1 products are currently listed.
Synonyms:
ATGRX2, ATGRXCP, C86710, CAX-interacting protein 2, CAX interacting protein 1, D13Wsu156e, F16M14.20, F16M14_20, GLRX, GLRX1, GLRXL, GLRXP3, GLUTAREDOXIN, Grx, GRX1, TTase, TTF, wu:fc38f02, zgc:103707
list all proteins Gene Name GeneID UniProt
GRX1 93692 Q9QUH0
GRX1 2745 P35754
GRX1 64045 Q9ESH6

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Glutaredoxin 1 Proteins (GRX1) by Origin

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Top referenced Glutaredoxin 1 Proteins

  1. Human Glutaredoxin 1 Protein expressed in Escherichia coli (E. coli) - ABIN2181166 : Yang, Jao, Nanduri, Starke, Mieyal, Qin: Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity. in Biochemistry 1999 (PubMed)

More Proteins for Glutaredoxin 1 Interaction Partners

Arabidopsis thaliana Glutaredoxin 1 (GRX1) interaction partners

  1. AtGRXcp has a glutaredoxin/thioredoxin-like (show TXN Proteins) fold with distinct structural features that differ from those of dithiol glutaredoxins.

  2. Results describe the initial functional characterization of a plant monothiol Glutaredoxin and suggests a conserved biological function in protecting cells against protein oxidative damage [AtGRXcp].

Mouse (Murine) Glutaredoxin 1 (GRX1) interaction partners

  1. Grx1 deficiency leads to eNOS (show NOS3 Proteins) dysfunction through oxidative modification of S-glutathionylation of eNOS (eNOS (show NOS3 Proteins)-SSG) and inactivation of NO production, enhancing the endothelial TLR4 (show TLR4 Proteins) activation, and ultimately exacerbating necrotizing enterocolitis severity.

  2. Study reports a decrease of Grx expression levels in pancreatic islets of diabetic mice which was accompanied by declining insulin (show INS Proteins) secretion, increase of reactive oxygen species (ROS (show ROS1 Proteins)) production level, and cell cycle alterations. These data demonstrate the essential role of the Grx system for the beta-cell during metabolic stress which may provide a new target for diabetes mellitus type 2 treatment.

  3. Our results indicate that Grx1 upregulation promotes neuroinflammation and consequent neuronal cell death in vitro, and synergizes with proinflammatory insults to promote DA loss in vivo.

  4. the Glrx1-Protein S-glutathionylation axis plays a pivotal role in house dust mite-induced allergic airways disease.

  5. Glrx ablation stabilizes HIF-1alpha (show HIF1A Proteins) by increasing GSH adducts on Cys (show DNAJC5 Proteins)(520) promoting in vivo HIF-1alpha (show HIF1A Proteins) stabilization, VEGF-A (show VEGFA Proteins) production, and revascularization in the ischemic muscles.

  6. Prx2 (show PRRX2 Proteins) glutathionylation is a favorable reaction that can occur in cells under oxidative stress and may have a role in redox signaling. GSH/Grx1 provide an alternative mechanism to thioredoxin (show TXN Proteins) and thioredoxin reductase (show PRDX2 Proteins) for Prx2 (show PRRX2 Proteins) recycling.

  7. The temporal relationships of Glrx1 with protein S-glutathionylation, glutathione, and cytokines/chemokines were observed as dynamic changes in lungs with allergic airway inflammation

  8. Glutaredoxin 1 plays an important role in controlling epithelial cell responsiveness to IL-17A (show IL17A Proteins)

  9. Up-regulated Glrx inhibits VEGF signaling by increa (show FLT1 Proteins)sed Flt1 causing impaired vascularization.

  10. S-glutathionylation of Fas (show FAS Proteins) in lung epithelium enhances epithelial apoptosis and clearance of P. aeruginosa. Glutaredoxin-1 impairs bacterial clearance and increases severity of pneumonia in association with deglutathionylation of Fas (show FAS Proteins).

Human Glutaredoxin 1 (GRX1) interaction partners

  1. Our results indicate that Grx1 upregulation promotes neuroinflammation and consequent neuronal cell death in vitro, and synergizes with proinflammatory insults to promote DA loss in vivo.

  2. Glutaredoxin desensitizes lens to oxidative stress by connecting and integrating specific signaling and transcriptional regulation for antioxidant response.

  3. Glrx ablation stabilizes HIF-1alpha (show HIF1A Proteins) by increasing GSH adducts on Cys (show DNAJC5 Proteins)(520) promoting in vivo HIF-1alpha (show HIF1A Proteins) stabilization, VEGF-A (show VEGFA Proteins) production, and revascularization in the ischemic muscles.

  4. The results demonstrate that the antiproliferative effect of NO is hampered by Trx1 (show MLL Proteins) and Grx1 and support the strategy of weakening the thiolic antioxidant defenses when designing new antitumoral therapies.

  5. Prx2 (show PRDX2 Proteins) glutathionylation is a favorable reaction that can occur in cells under oxidative stress and may have a role in redox signaling. GSH/Grx1 provide an alternative mechanism to thioredoxin (show TXN Proteins) and thioredoxin reductase (show PRDX5 Proteins) for Prx2 (show PRDX2 Proteins) recycling.

  6. Glutaredoxin 1 protects human retinal pigment epithelial cells from oxidative damage by preventing AKT (show AKT1 Proteins) glutathionylation.

  7. A new function for GRX1 in neuronal copper homeostasis and in protection from copper-mediated oxidative injury.

  8. Human Grx1 can catalyse reduction of Atox1 (show ATOX1 Proteins) by glutathione but only in the presence of Cu(I).

  9. Levels of GLRX in the cerebrospinal fluid increase significantly in the early stages of Alzheimer's disease.

  10. Glrx overexpression increased soluble VEGF receptor (show FLT1 Proteins) 1 (sFlt) in endothelial cells via NF-kappaB (show NFKB1 Proteins)-dependent Wnt5a (show WNT5A Proteins) production.

Pig (Porcine) Glutaredoxin 1 (GRX1) interaction partners

  1. Results indicate that the activation of eNOS (show NOS3 Proteins)/NO system is regulated by Grx 1 and coupled with inhibition of JNK (show MAPK8 Proteins) and NF-kappaB (show NFKB1 Proteins) signaling pathway which could alleviate the oxidative stress/apoptosis in coronary arteries endothelial cells induced by HG.

Glutaredoxin 1 (GRX1) Protein Profile

Protein Summary

This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.

Alternative names and synonyms associated with Glutaredoxin 1 (GRX1)

  • hypothetical protein (Glutaredoxin)
  • hypothetical protein (glutaredoxin)
  • glutaredoxin (thioltransferase) (glrx)
  • glutaredoxin (thioltransferase) (GLRX)
  • glutaredoxin (thioltransferase) pseudogene 3 (GLRXP3)
  • CAX-interacting protein 2/monothiol glutaredoxin (CXIP2)
  • CAX interacting protein 1 (CXIP1)
  • glutaredoxin (grx-1) (grx-1)
  • glutaredoxin Grx1 (grx1)
  • glutaredoxin Grx1 (AFUA_1G06100)
  • glutaredoxin-1 (Grx1) (NT01EI_2528)
  • glutaredoxin (Glrx)
  • glutaredoxin (thioltransferase) (Glrx)
  • Glutaredoxin-1-like (LOC100344913)
  • ATGRX2 protein
  • ATGRXCP protein
  • C86710 protein
  • CAX-interacting protein 2 protein
  • CAX interacting protein 1 protein
  • D13Wsu156e protein
  • F16M14.20 protein
  • F16M14_20 protein
  • GLRX protein
  • GLRX1 protein
  • GLRXL protein
  • GLRXP3 protein
  • GLUTAREDOXIN protein
  • Grx protein
  • GRX1 protein
  • TTase protein
  • TTF protein
  • wu:fc38f02 protein
  • zgc:103707 protein

Protein level used designations for Glutaredoxin 1 Proteins (GRX1)

hypothetical protein , thioltransferase , glutaredoxin (thioltransferase) , glutaredoxin (thioltransferase) pseudogene 3 , glutaredoxin (thioltransferase)-like , glutaredoxin (grx-1) , glutaredoxin Grx1 , glutaredoxin-1 (Grx1) , thiol disulfide oxidoreductase , TTase-1 , glutaredoxin 1 (thioltransferase) , glutaredoxin-1 , thioltransferase-1 , fc38f02 , TTase

GENE ID SPECIES
175568 Caenorhabditis elegans
181766 Caenorhabditis elegans
549351 Xenopus (Silurana) tropicalis
695550 Macaca mulatta
695565 Macaca mulatta
698997 Macaca mulatta
736317 Pan troglodytes
737587 Pan troglodytes
786206 Bos taurus
818407 Arabidopsis thaliana
824655 Arabidopsis thaliana
1484764 Archaeoglobus fulgidus DSM 4304
2543556 Schizosaccharomyces pombe 972h-
3507618 Aspergillus fumigatus Af293
7958866 Edwardsiella ictaluri 93-146
100147797 Ovis aries
93692 Mus musculus
2745 Homo sapiens
449769 Danio rerio
609246 Canis lupus familiaris
397463 Sus scrofa
515416 Bos taurus
64045 Rattus norvegicus
396069 Gallus gallus
100344913 Oryctolagus cuniculus
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