Browse our Thioredoxin Reductase 2 Proteins (TXNRD2)

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Thioredoxin Reductase 2 Proteins (TXNRD2)
On are 9 Thioredoxin Reductase 2 (TXNRD2) Proteins from 4 different suppliers available. Additionally we are shipping Thioredoxin Reductase 2 Antibodies (65) and Thioredoxin Reductase 2 Kits (3) and many more products for this protein. A total of 79 Thioredoxin Reductase 2 products are currently listed.
AA118373, CG11401, Dm-TrxR, Dmel\\CG11401, DmTrx, DmTrxR-2, ESTM573010, SELZ, TGR, TR, TR-BETA, Tr3, trxr-2, TRXR2, Trxrd2
list all proteins Gene Name GeneID UniProt
TXNRD2 10587 Q9NNW7
TXNRD2 26462 Q9JLT4
Rat TXNRD2 TXNRD2 50551 Q9Z0J5

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Thioredoxin Reductase 2 Proteins (TXNRD2) by Origin

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More Proteins for Thioredoxin Reductase 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Thioredoxin Reductase 2 (TXNRD2) interaction partners

Human Thioredoxin Reductase 2 (TXNRD2) interaction partners

  1. TrxR2 was overexpressed in non-small-cell lung cancer cells; our results suggest that TrxR2 acts as an oncogenic gene in the context of lung cancer progression

  2. p53R2 (show RRM2B Proteins) acts as a positive regulator of TrxR2 activity in mitochondria both under normal physiological conditions and during the cellular response to DNA damage

  3. TrxR2 deficiency-induced impaired proliferation and death of chondrocytes may be the pathological mechanism of the osteoarthropathy due to Selenium deficiency.

  4. Evidence that the rs4485648 polymorphism of the TrxR2 gene might exert an independent effect on the development of Diabetic retinopathy.

  5. Data suggest that TXNRD2 may represent a druggable target that could be deployed to reduce the development of fatal pulmonary metastases in patients with osteosarcoma (OS).

  6. A meta-analysis of the top SNPs identified three new associated loci in primary open angle glaucoma--TXNRD2, ATXN2 (show ATXN2 Proteins), and FOXC1 (show FOXC1 Proteins)

  7. The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for Myocardial infarction in subjects with T2 Diabetes mellitus of Slovenian origin.

  8. Data suggest TXNRD1 (show TXNRD1 Proteins) and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults.

  9. Absence of TXNRD2 in humans leads to glucocorticoid deficiency.

  10. Single Nucleotide Polymorphisms in the genes GPX1 (show GPX1 Proteins) (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (show DIO2 Proteins) (rs225014) may not be significantly associated with Kashin-Beck disease in a Tibetan population.

Mouse (Murine) Thioredoxin Reductase 2 (TXNRD2) interaction partners

  1. Maintenance of mitochondrial ROS (show ROS1 Proteins) via Txnrd2 in endothelial cells is necessary for an intact vascular homeostasis and remodeling. Txnrd2 plays a vitally important role in balancing mitochondrial ROS (show ROS1 Proteins) production in the endothelium.

  2. Suggest role for Txnrd2 in sustaining heart function during aging and suggest that Txnrd2 may be a modifier of heart failure.

  3. Regulatory link was discovered between mitochondrial Txnrd and the JNK (show MAPK8 Proteins)-PHD2 (show EGLN1 Proteins)-Hif-1alpha (show HIF1A Proteins) axis, which highlights how the loss of Txnrd2 and the resulting altered mitochondrial redox balance impairs tumor growth as well as tumor-related angiogenesis.

  4. Data suggest TXNRD1 (show TXNRD1 Proteins) and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults.

  5. The SirT1 (show SIRT1 Proteins) regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase (show SOD2 Proteins), catalase (show CAT Proteins), peroxiredoxins 3 and 5, thioredoxin 2 (show TXN2 Proteins), thioredoxin reductase 2, and uncoupling protein 2 (show UCP2 Proteins).

  6. Data indicate that mammalian thioredoxin reductase (H-TrxR) reduces hypothiocyanous acid (HOSCN).

  7. Txnrd2 exerts a crucial function during postischemic reperfusion via thiol regeneration.

  8. Energization of mitochondria increases the antioxidant potential of the TrxR2/Trx2 (show TXN2 Proteins) system and that inhibition of TrxR2 results in increased H(2)O(2) emission.

  9. Genomic organization and identification of a novel alternative splicing variant of mouse mitochondrial TrxR2 gene

  10. Neither Trx2 (show TXN2 Proteins) nor TrxR2 gain of function modified the redox regulation of mitochondria-dependent apoptosis in cos-7 cells, Hela cells and Mouse Neuro2a cells.

Thioredoxin Reductase 2 (TXNRD2) Protein Profile

Protein Summary

Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22.

Alternative names and synonyms associated with Thioredoxin Reductase 2 (TXNRD2)

  • thioredoxin reductase 2 (Trxr-2)
  • thioredoxin reductase 2 (TXNRD2)
  • thioredoxin reductase 2 (Txnrd2)
  • AA118373 protein
  • CG11401 protein
  • Dm-TrxR protein
  • Dmel\\CG11401 protein
  • DmTrx protein
  • DmTrxR-2 protein
  • ESTM573010 protein
  • SELZ protein
  • TGR protein
  • TR protein
  • TR-BETA protein
  • Tr3 protein
  • trxr-2 protein
  • TRXR2 protein
  • Trxrd2 protein

Protein level used designations for TXNRD2

CG11401-PA , Trxr-2-PA , thioredoxin reductase , thioredoxin-reductase-2 , selenoprotein Z , thioredoxin reductase 2, mitochondrial , thioredoxin reductase 3 , thioredoxin reductase TR3 , thioredoxin reductase beta , TR beta

40475 Drosophila melanogaster
10587 Homo sapiens
26462 Mus musculus
50551 Rattus norvegicus
282389 Bos taurus
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