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anti-Human alpha Defensin 1 Antibodies:
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Human Polyclonal alpha Defensin 1 Primary Antibody for ELISA, IHC - ABIN4279832
Chang, Vargas, DelPortillo, Klotman: Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. in The Journal of clinical investigation 2005
Human Polyclonal alpha Defensin 1 Primary Antibody for ELISA, WB - ABIN2473294
Castañeda-Delgado, Cervantes-Villagrana, Serrano-Escobedo, Frausto-Lujan, Rivas-Santiago, Enciso-Moreno, Rivas-Santiago: Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infection. in Memórias do Instituto Oswaldo Cruz 2014
HNP1 upregulation of cytokine expression in pDCs was inhibited by blockade of NF-kappaB (show NFKB1 Antibodies) activation or knockdown of IRF1 (show IRF1 Antibodies), demonstrating the importance of these two signaling events in HNP1-induced pDC (show PNKD Antibodies) activation.
these results demonstrate that HNPs1-3 may be potent inhibitors of ADAMTS13 (show ADAMTS13 Antibodies) activity, likely by binding to the central A2 domain of VWF (show VWF Antibodies) and physically blocking ADAMTS13 (show ADAMTS13 Antibodies) binding.
Increased alpha-defensin (show DEF Antibodies) expression is associated with risk of coronary heart disease in hyperlipidemia patients.
Levels in sera and CSF (show CSF2 Antibodies) were elevated in Alzheimer disease patients compared with controls.
the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases.
Increased levels of neutrophil defensin 1, apolipoprotein E (show APOE Antibodies), clusterin (show CLU Antibodies), and zinc-alpha-2-glycoprotein (show AZGP1 Antibodies) are present in carotid atherosclerotic plaque secretomes.
HNP1 functions as a "molecular brake" on macrophage-driven inflammation, ensuring both pathogen clearance and the resolution of inflammation with minimal bystander tissue damage.
HP1 binding to the chromosomal passenger complex becomes particularly important when Aurora B (show AURKB Antibodies) phosphorylates kinetochore targets to eliminate erroneous microtubule attachments
data demonstrate that HNP-1 induces IL-8 (show IL8 Antibodies) production not only through P2Y6 (show P2RY6 Antibodies), but also through additional P2 receptors via an ERK1/2 (show MAPK1/3 Antibodies)-dependent mechanism in intestinal epithelial cells.
Results showed that NO and NaNO2 can be considered as factors regulating the chemoattractant properties of defensin (show DEF Antibodies) HNP1 in neutrophils
Decreased alpha-defensin (show DEF Antibodies) is associated with intestinal inflammation in a model of inflammatory bowel disease.
cryptdin-1 and cryptdin-4 exhibit circadian oscillation
the Arg5-Glu13 salt bridge in alpha-defensin (show DEF Antibodies) is conserved for defensin (show DEF Antibodies) in vivo stability
MMP-7 (show MMP7 Antibodies) activates mouse paneth cell pro-alpha-defensins
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
defensin, alpha 1, myeloid-related sequence
, defensin, alpha 2
, myeloid-related sequence
, neutrophil defensin 1
, alpha-defensin 1
, defensin related cryptdin peptide 1
, defensin-related cryptdin peptide
, defensin alpha 1
, Paneth cell-specific alpha-defensin 2
, Neutrophil defensin 1
, Neutrophil defensin 3
, neutrophil defensin 8