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Mouse (Murine) ARG1 ELISA Kit for Sandwich ELISA - ABIN810912
Hayakawa, Okazaki, Morioka, Nakamura, Tanaka, Ogata: Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury. in Journal of neuroscience research 2014
The data in this study suggest that arginase I inhibition potentially represents a novel therapeutic target for the prevention and/or treatment of bronchopulmonary dysplasia-associated pulmonary hypertension.
this study shows that infiltrating macrophages expressing Arg1 are present in active allergic contact dermatitis lesions
High arginase expression is associated with glioblastoma.
Report the value of Arg-1 in distinguishing HepPar-1-positive prostatic carcinoma from hepatocellular carcinoma at metastatic sites or cases of liver metastasis from prostate carcinoma.
AEG-1 (show MTDH ELISA Kits) is positively activated in the tumorigenesis and deterioration of NSCLC.
Arginase-1 expression is common (62.5%) in hepatoid adenocarcinoma and hence it is not useful in distinguishing hepatocellular carcinoma from hepatoid adenocarcinoma.
Arginase 1 was highly expressed by tumor-associated Gr1+ microglia and macrophages.
The authors report here that Candida albicans blocks nitric oxide production in human-monocyte-derived macrophages by induction of host arginase activity.
Evidence for a negative association of arginase I with job strain and positive association with job control and social support in females.
Two argininemia patients were initially diagnosed by tandem mass spectrometry in newborn screening. Mutation analysis of the ARG1 gene was performed by direct sequencing.Two missense mutations, p.D100N and p.R71T, in Patient-1 were predicted to lower the stability of arginase Iota by analysis of 3D crystal structure, while two nonsense mutations, p.G12X and p.E42X, in Patient-2 were predicted to lead to truncated protein.
Arginase has a role in preventing angiogenesis in endothelial cells exposed to hypoxia
Ang II (show AGT ELISA Kits) increases endothelial arginase activity/expression through a p38 MAPK (show MAPK14 ELISA Kits)/ATF-2 (show ATF2 ELISA Kits) pathway leading to reduced endothelial NO production
results indicate that arginase induction depends in part on epidermal growth factor (EGF (show EGF ELISA Kits)) receptor (show EGFR ELISA Kits) activity, and that EGFR (show EGFR ELISA Kits) inhibitors may attenuate vascular remodeling without affecting nitric oxide release
high glucose (HG)-treated bovine coronary endothelial cells (BCECs) showed increased arginase activity and diminished NO production
Deletion of Arg1 in hematopoietic cells adversely affects blood leukocyte counts and increases foam cell formation. However, no effects on atherosclerosis could be demonstrated, indicating that hematopoietic Arg1 function is not a decisive factor in atherosclerotic plaque formation.
diabetes-dependent increase in renal arginase-2 (show ARG2 ELISA Kits) expression also requires arginase-1 expression in macrophages
this study shows that mice lacking Arg1 in macrophages develop increased allergic contact hypersensitivity
this study shows that Ron (show MST1R ELISA Kits) is expressed in a subpopulation of macrophages during chronic inflammation induced by obesity that exhibit a repair phenotype as determined by the expression of arginase 1
This study uncovers synergistic activation of Arg1 by retinoic acid and IL-4 (show IL4 ELISA Kits) in M2 macrophages.
this study shows that group 2 innate lymphoid cells selectively express arginase 1 and that this is critical for their bioenergetics, proliferation and function
this study shows that c-Jun (show JUN ELISA Kits) regulates the activation state of macrophages and promotes arthritis via differentially regulating cyclooxygenase-2 (show PTGS2 ELISA Kits) and arginase-1 levels
deletion or TNF-mediated restriction of Arg1 unleashes the production of nitric oxide by NOS2, which is critical for pathogen control.
Data indicate that transfected mouse arginase-1 (Arg-I) promotes endothelial senescence and inflammatory responses through eNOS (show NOS3 ELISA Kits)-uncoupling in human umbilical vein endothelial cells (HUVEC cells).
The immunosuppressive effect of a purified substance (ISF (show ATP6V0A2 ELISA Kits)) in the culture medium of neonatal pig liver fragments was due to arginase activity that decreased arginine concentration in culture medium, not to another function of ISF (show ATP6V0A2 ELISA Kits).
Results show that ischemia markedly potentiated the expression of arginase-1, and also induced the SOD2 (show SOD2 ELISA Kits) in the wound tissue.
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.
, liver-type arginase
, type I arginase
, arginase 1
, arginase I
, arginase 1, liver
, AI type I arginase
, arginase, hepatic