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Data showed that the N-terminus of Hyx-Wt-HA was exclusively acetylated whereas the amino terminus of Hyx-A2P-HA always remained unmodified.
Data show that Drosophila Hyrax and its human ortholog, Parafibromin, are required for nuclear transduction of the Wnt/Wg signal and bind directly to the C-terminal region of beta-catenin/Armadillo.
These results suggest a target gene-selective involvement of the PAF1 (show PAF1 ELISA Kits) complex in Hh signaling via the Parafibromin/Hyx-mediated recruitment to Gli (show GLI1 ELISA Kits)/Ci.
Data suggest that down-regulated parafibromin (HRPT2; CDC73) expression might be closely linked to colorectal carcinogenesis and cancer differentiation.
A novel deletion of exons 4 to 10 of CDC73 was detected by CNV analysis in the three affecteds. A novel insertion in the 5'UTR (show UTS2R ELISA Kits) (c.-4_-11insG) that co-segregated with the deletion was identified.
Germline mutation of HRPT2 is associated with parathyroid carcinoma.
parafibromin downregulation might promote the pathogenesis, dedifferentiation and metastasis of ovarian cancers possibly by suppressing aggressive phenotypes, such as proliferation, cell cycle, apoptosis, migration and invasion.
We suggest that parafibromin may be a possible prognostic and predictive parameter for breast carcinomas
These findings suggest that downregulated expression of parafibromin protein plays an important role in the pathogenesis, differentiation, and metastasis of head and neck squamous cell carcinomas
Parafibromin interacted with JAK1 (show JAK1 ELISA Kits)/2, promoted the interactions of JAK1 (show JAK1 ELISA Kits)-JAK2 (show JAK2 ELISA Kits) and JAK1 (show JAK1 ELISA Kits)/2-STAT1 (show STAT1 ELISA Kits), and promoted tyrosine phosphorylation of STAT1 (show STAT1 ELISA Kits) by JAKs after IFN-gamma (show IFNG ELISA Kits) stimulation.
targets and destabilizes p53 (show TP53 ELISA Kits) mRNA to control p53 (show TP53 ELISA Kits)-mediated apoptosis
Data report a novel mutation in the CDC73 gene that may underlie HPT-JT syndrome.
gene expression profiling experiments suggest that upregulated FGFR1 (show FGFR1 ELISA Kits) expression appears to be associated with parathyroid carcinoma in HPT-JT syndrome due to an HRPT2 splicing mutation
Uterine neoplasms, myometria and jaw bones of Cdc73(+/-) mice had increased proliferation rates that were 2-fold higher than in Cdc73(+/+) mice.
These results aid in our understanding of the role parafibromin plays within transcriptional regulation, terminal differentiation, and bone homeostasis
Data indicate that isruption of the MLL (show MLL ELISA Kits)-PAFc subunit, Cdc73 (Hrpt2) interaction selectively inhibits the proliferation of MLL (show MLL ELISA Kits) leukemic cells.
Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation
Expression of Hrpt2 and parafibromin is pivotal in mammalian development and survival in adults and that these functions are likely mediated by the transcriptional regulation of growth factors.
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.
, CDC37 cell division cycle 37 homolog
, cell division cycle 37 homolog
, hsp90 co-chaperone Cdc37
, hyperparathyroidism 2 homolog
, Paf1/RNA polymerase II complex component
, cell division cycle 73, Paf1/RNA polymerase II complex component, homolog
, cell division cycle protein 73 homolog
, hyperparathyroidism 2 protein
, hyperparathyroidism 2 (with jaw tumor)
, hyperparathyroidism 2 protein homolog
, Vcell division cycle 73, Paf1/RNA polymerase II complex component, homolog
, hyperparathyroidism 2 with jaw tumor protein