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alpha-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans
Downregulation of HD6 in noninflamed mucosa may contribute to mucosal barrier dysfunction of patients with Crohn's Disease.
Paneth cell alpha-defensin 6 is an antimicrobial peptide (show cAMP Proteins).
Native HD-6 readily self-assembles into elongated fibrils observable by transmission electron microscopy, agglutinates both Gram-negative and -positive bacteria, and prevents the Listeria monocytogenes from invading cultured cells.
Authors show that although NOD2 by itself can slightly up-regulate expression of HD5 (show DEFA5 Proteins) and HD6, it can strongly down-regulates their expression during differentiation of the Paneth cell lineage mainly by inhibiting activation of the MAPK (show MAPK1 Proteins) pathway.
In the meta-analysis, DEFA6 rs13275170 and DEFB1 (show DEFB1 Proteins) rs2738169 had both a 1.3-fold increased odds ratio for gastric cancer.
study reports that HD6 affords protection against invasion by enteric bacterial pathogens in vitro and in vivo; after stochastic binding to bacterial surface proteins, HD6 undergoes ordered self-assembly to form fibrils and nanonets that surround and entangle bacteria
Defensin alpha 6 (DEFA 6) may have a role in adenoma but not in progression to colon carcinoma
defensin (show DEF Proteins) alpha6 is highly expressed in colon cancer cell lines
Crystal structure of HD6.
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel.
defensin, alpha 6, Paneth cell-specific
, alpha-defensin 6, Paneth cell-specific
, Paneth cell-specific alpha-defensin 6
, alpha-defensin 6
, defensin 6
, alpha-defensin 6/12
, alpha-defensin, 6
, defensin related cryptdin 6
, defensin-related cryptdin-6/12