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Gene copy number variation (CNV) of the PKLR (show PKLR ELISA Kits), FCGR2A (show FCGR2A ELISA Kits), FCGR2C, and FCGR3 (show CD16 ELISA Kits) genes is associated with malaria severity, and our results provide evidence for a role of CNV in host responses to malaria.
results indicate that FcgammaRIIB is not uniquely able to promote membrane recruitment of SHIP, but rather modulates its function via formation of distinct signaling complexes. Membrane recruitment of SHIP via Syk (show SYK ELISA Kits)-dependent mechanisms may be an important factor modulating immunoreceptor signaling.
FCGR2A (show FCGR2A ELISA Kits) and FCGR2C polymorphisms may also contribute to immunocomplexemia present in sarcoidosis.
Fc gamma receptor IIb was significantly elevated in abdominal aortic aneurysm (AAA (show APP ELISA Kits)) tissues compared to normal aortas. Fc gamma receptor IIb may be involved in the pathogenesis of AAA (show APP ELISA Kits) by regulation of inflammatory reactions.
Fc-gamma receptor (show FCGR1A ELISA Kits) polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis.
FCGR2C SNPs that associated with vaccine efficacy in RV144 also strongly associated with the expression of FCGR2A (show FCGR2A ELISA Kits)/C and one of them also associated with the expression of Fc receptor-like A (FCRLA (show FCRLA ELISA Kits)), another Fc-gamma receptor (show FCGR1A ELISA Kits) (FcgammaR) gene
LPS (show IRF6 ELISA Kits) activation of TLR4 (show TLR4 ELISA Kits) significantly increased MARCH3 (show MARCH3 ELISA Kits) expression and that siRNA against MARCH3 (show MARCH3 ELISA Kits) prevented the decrease in FcgammaRIIb following LPS (show IRF6 ELISA Kits) treatment.
a rare FCGR2B null-variant allele was found, in which a polymorphic stop codon of FCGR2C is introduced into one FCGR2B gene
Data show that gains or losses in copy numbers of Fc gamma receptors FCGR3A (show CD16 ELISA Kits) were less frequent than for FCGR3B (show CD16 ELISA Kits) and FCGR2C.
FcgammaRIIB requires Btk (show BTK ELISA Kits) and p38 MAPK (show MAPK14 ELISA Kits) to mediate antigen-independent inhibition in human B cells.
The authors concluded that the FcgammaRIIb-SHIP2 (show INPPL1 ELISA Kits) axis links Abeta (show APP ELISA Kits) neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease.
This study reports the creation of a mouse model of autoimmunity-associated atherosclerosis by transplanting bone marrow from FcgammaRIIB knockout (FcRIIB(-/-)) mice into LDL receptor (show LDLR ELISA Kits) knockout mice.
These results reveal a novel and unexpected function of hepatic Fc-gamma-RIIB in the targeted downregulation of GPVI (show GP6 ELISA Kits) in vivo.
Cytokine release was quantified from FVIII(-/-) splenocytes restimulated with FVIII in the absence or presence of different anti-FcgammaRIIB (CD32) Antibodies (anti-CD32 mAbs) over 6 days.
Collectively these findings reveal that by inhibiting eNOS (show NOS3 ELISA Kits), endothelial FcgammaRIIB activation by CRP (show CRP ELISA Kits) blunts insulin (show INS ELISA Kits) delivery to skeletal muscle to cause insulin (show INS ELISA Kits) resistance.
Macrophages' activating FcgammaR expression profile are associated with the development of ITP (show ITPA ELISA Kits) in Treg-deficient mice.
this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1 (show INPP5D ELISA Kits)/2 and Inpp4a (show INPP4A ELISA Kits), and accelerates phagosome acidification
CD32 is a crucial regulator of FVIII (show F8 ELISA Kits)-specific B cells and is required for the differentiation of memory B cells into antibody-secreting cells.
Aggregated alpha-Synuclein (alpha-syn) inhibited microglial phagocytosis. The inhibitory effect of aggregated alpha-syn on microglial phagocytosis was due to the activation of SHP-1 and FcgammaRIIB on microglia.
Fcgr2b(-/-) mice lose bone upon the onset of a hypergammaglobulinemia or the administration of IgG1 immune complexes.
This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants.
, Fc fragment of IgG, low affinity II, receptor for (CD32)
, Fc fragment of IgG, low affinity IIb, receptor for (CD32)
, Fc gamma RIIb
, fc-gamma RII-b
, igG Fc receptor II-b
, low affinity immunoglobulin gamma Fc region receptor II-b
, Fc fragment of IgG, low affinity IIb, receptor (CD32)
, Fc fragment of IgG, low affinity IIb, receptor
, IgG Fc gamma receptor II
, fc-gamma RII
, igG Fc receptor II
, low affinity immunoglobulin gamma Fc region receptor II
, Fc gamma RIIB
, fc gamma receptor IIB
, igG Fc receptor II beta
, lymphocyte antigen 17
, Fc gamma receptor IIC
, IgG Fc receptor II-c
, immunoglobulin G Fc receptor II-c
, low affinity immunoglobulin gamma Fc region receptor II-c
, FC-gamma RII
, Fc receptor, IgG, low affinity IIb
, low affinity immunoglobulin gamma FC region receptor II
, Fc-gamma RII
, IgG Fc receptor II