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This first genome-wide association approach for cyclophosphamide response in lupus nephritis patients yielded a robust profile of genetic associations including large-effect SNP in the FCGR2B-FCRLA (show FCRLA ELISA Kits) locus, which may provide better insights to cyclophosphamide metabolism and efficacy.
results indicate that FcgammaRIIB is not uniquely able to promote membrane recruitment of SHIP, but rather modulates its function via formation of distinct signaling complexes. Membrane recruitment of SHIP via Syk (show SYK ELISA Kits)-dependent mechanisms may be an important factor modulating immunoreceptor signaling.
Fc gamma receptor IIb was significantly elevated in abdominal aortic aneurysm (AAA (show APP ELISA Kits)) tissues compared to normal aortas. Fc gamma receptor IIb may be involved in the pathogenesis of AAA (show APP ELISA Kits) by regulation of inflammatory reactions.
Fc-gamma receptor (show FCGR1A ELISA Kits) polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis.
LPS (show IRF6 ELISA Kits) activation of TLR4 (show TLR4 ELISA Kits) significantly increased MARCH3 (show MARCH3 ELISA Kits) expression and that siRNA against MARCH3 (show MARCH3 ELISA Kits) prevented the decrease in FcgammaRIIb following LPS (show IRF6 ELISA Kits) treatment.
a rare FCGR2B null-variant allele was found, in which a polymorphic stop codon of FCGR2C is introduced into one FCGR2B gene
FcgammaRIIB requires Btk (show BTK ELISA Kits) and p38 MAPK (show MAPK14 ELISA Kits) to mediate antigen-independent inhibition in human B cells.
The FCGR2B variant leads to reduced serum IL-6 (show IL6 ELISA Kits), later disease onset and reduced need for biological treatment, but does not seem to aggravate RA. The TM region variant is associated with a lower activation state of the Tregs and naive and memory B cells.
FcgIIb on GM-CSF (show CSF2 ELISA Kits) macrophages has a role in controlling immune complex-mediated inhibition of inflammatory signals
none of the three functional polymorphisms in FcgammaR genes explored here, the FCGR3A (show CD16 ELISA Kits) F158V and FCGR2B I232T nsSNPs and the VNTR in FCGRT (show FCGRT ELISA Kits), showed an association with the response to TNFi in patients with rheumatoid arthritis
PLCd1 (show PLCD1 ELISA Kits) negatively regulates lipopolysaccharide-induced production of IL-1b (show IL1B ELISA Kits) and Fc gamma receptor (show FCGR1A ELISA Kits)-mediated phagocytosis in macrophages.
The authors concluded that the FcgammaRIIb-SHIP2 (show INPPL1 ELISA Kits) axis links Abeta (show APP ELISA Kits) neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease.
This study reports the creation of a mouse model of autoimmunity-associated atherosclerosis by transplanting bone marrow from FcgammaRIIB knockout (FcRIIB(-/-)) mice into LDL receptor (show LDLR ELISA Kits) knockout mice.
These results reveal a novel and unexpected function of hepatic Fc-gamma-RIIB in the targeted downregulation of GPVI (show GP6 ELISA Kits) in vivo.
Cytokine release was quantified from FVIII(-/-) splenocytes restimulated with FVIII in the absence or presence of different anti-FcgammaRIIB (CD32) Antibodies (anti-CD32 mAbs) over 6 days.
Collectively these findings reveal that by inhibiting eNOS (show NOS3 ELISA Kits), endothelial FcgammaRIIB activation by CRP (show CRP ELISA Kits) blunts insulin (show INS ELISA Kits) delivery to skeletal muscle to cause insulin (show INS ELISA Kits) resistance.
Macrophages' activating FcgammaR expression profile are associated with the development of ITP (show ITPA ELISA Kits) in Treg-deficient mice.
this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1 (show INPP5D ELISA Kits)/2 and Inpp4a (show INPP4A ELISA Kits), and accelerates phagosome acidification
CD32 is a crucial regulator of FVIII (show F8 ELISA Kits)-specific B cells and is required for the differentiation of memory B cells into antibody-secreting cells.
Aggregated alpha-Synuclein (alpha-syn) inhibited microglial phagocytosis. The inhibitory effect of aggregated alpha-syn on microglial phagocytosis was due to the activation of SHP-1 and FcgammaRIIB on microglia.
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
, Fc fragment of IgG, low affinity II, receptor for (CD32)
, Fc fragment of IgG, low affinity IIb, receptor for (CD32)
, Fc gamma RIIb
, fc-gamma RII-b
, igG Fc receptor II-b
, low affinity immunoglobulin gamma Fc region receptor II-b
, Fc fragment of IgG, low affinity IIb, receptor (CD32)
, Fc fragment of IgG, low affinity IIb, receptor
, IgG Fc gamma receptor II
, fc-gamma RII
, igG Fc receptor II
, low affinity immunoglobulin gamma Fc region receptor II
, Fc gamma RIIB
, fc gamma receptor IIB
, igG Fc receptor II beta
, lymphocyte antigen 17
, FC-gamma RII
, Fc receptor, IgG, low affinity IIb
, low affinity immunoglobulin gamma FC region receptor II
, Fc-gamma RII
, IgG Fc receptor II
, Fc gamma receptor II