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downregulation of HMGB1 and/or HMGB2 in undifferentiated human embryonic stem cells does not affect the stemness of cells.
Serum HMGB2 levels were associated with in-stent restenosis in patients.
results establish HMGB2 as a novel master regulator that orchestrates senescence-associated secretory phenotype.
Data indicate the function of high mobility group box 2 (HMGB2) in glycolytic control in pancreatic cancer.
data demonstrate a reciprocal relationship between Hmgb2 and Ctcf (show CTCF ELISA Kits) in controlling aspects of chromatin structure and gene expression.
Lrp1 (show LRP1 ELISA Kits)-antisense directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1 (show LRP1 ELISA Kits).
Data show that odulation of RNA helicase (show DDX46 ELISA Kits) DDX18 (show DDX18 ELISA Kits) directly affects growth of tamoxifen-resistant cells, suggesting that it may be a critical downstream effector of the estrogen receptors (ERs) and high mobility group box 2 (HMGB2) complex.
siRNA-mediated silencing of HMGB2 increased the sensitivity of the head and neck squamous cell carcinoma cell lines to cisplatin and 5-fluorouracil.
the combination of a HMGB1+ and HMGB2- expression potentially predicts a poor prognosis in patients with pancreatic ductal adenocarcinoma
This study found that single nucleotide polymorphisms of HMGB1 (show HMGB1 ELISA Kits) may serve as potential biomarkers for predicting the efficacy of platinum-based chemotherapy.
these results highlight the previously undiscovered and crucial role of the HMGB2-IGF2BP2 (show IGF2BP2 ELISA Kits) axis in myogenesis and muscle regeneration.
HMGB2 promoted neointimal hyperplasia in mice with arterial wire injury through reactive oxygen species activation.
HMGB2 functions as a modulator of neurogenesis in young adult mice through regulation of neural stem cell proliferation.
Oct4 post-translational modifications (PTMs) form a positive feedback loop, which promotes Akt activation and interaction with Hmgb2 and the SET complex.
HMGB2 (but not HMGB1 (show HMGB1 ELISA Kits)) suppresses pathologic cell growth in vivo and controls a gene expression program responsible for hypertrophic cell growth
The age-related loss of HMGB2 in articular cartilage may represent a mechanism responsible for the decline in adult cartilage stem cell populations.
Data show that Hmgb1 and Hmgb2 function redundantly to enhance Wnt signaling in embryos, and further suggest that integrating Wnt, Shh, and BMP signaling regulates the development of digit5 in forelimbs.
High levels of HMGB2 directly correlate with the extent of neoplastic changes in cutaneous squamous cell carcinoma. HMGB2 is an effective stimulus for cell differentiation, tumor progression, & metastatic invasion.
results show that, in contrast to other Arabidopsis HMGB proteins such as HMGB1 and HMGB5, the HMGB2/3 and HMGB4 proteins occur preferentially in the cell nucleus, but to various extents also in the cytoplasm
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
, high mobility group protein 2
, high mobility group protein B2
, high-mobility group (nonhistone chromosomal) protein 2
, high-mobility group box 2
, non-histone chromosomal protein
, non-histone protein HMG2