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Browse our IL-10 Proteins (IL10)

Full name:
Interleukin 10 Proteins (IL10)
On www.antibodies-online.com are 181 Interleukin 10 (IL10) Proteins from 23 different suppliers available. Additionally we are shipping IL-10 Antibodies (708) and IL-10 Kits (297) and many more products for this protein. A total of 1210 IL-10 products are currently listed.
Synonyms:
CSIF, GVHDS, Il-10, IL10A, IL10X, TGIF
list all proteins Gene Name GeneID UniProt
IL10 3586 P22301
IL10 16153 P18893
Rat IL10 IL10 25325 P29456

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IL-10 Proteins (IL10) by Origin

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Top referenced IL-10 Proteins

  1. Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2666701 : Asadullah, Sterry, Volk: Interleukin-10 therapy--review of a new approach. in Pharmacological reviews 2003 (PubMed)
    Show all 6 references for ABIN2666701

  2. Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305073 : Howard, OGarra, Ishida, de Waal Malefyt, de Vries: Biological properties of interleukin 10. in Journal of clinical immunology 1992 (PubMed)
    Show all 4 references for ABIN1305073

  3. Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN413418 : van der Vliet, Wang, Yue, Koon, Balk, Exley: Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 3 references for ABIN413418

  4. Cat (Feline) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2008820 : Yoon, Jones, Logsdon, Walter: Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. in Structure (London, England : 1993) 2005 (PubMed)
    Show all 3 references for ABIN2008820

  5. Wild boar (Sus scrofa) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2008795 : Gesser, Leffers, Jinquan, Vestergaard, Kirstein, Sindet-Pedersen, Jensen, Thestrup-Pedersen, Larsen: Identification of functional domains on human interleukin 10. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 2 references for ABIN2008795

  6. Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305072 : Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 2 references for ABIN1305072

  7. Rat (Rattus) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN2009133 : Cui, Feng, Wang, Zhao: [Expression of RhoA in the lung tissue of acute lung injury rats and the influence of RhoA on the expression of IL-8 and IL-10]. in Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2011 (PubMed)

More Proteins for IL-10 Interaction Partners

Human Interleukin 10 (IL10) interaction partners

  1. Investigating the association between this polymorphism and risk of Inflammatory bowel disease. Meta-analysis suggests that the IL-10 gene -819C/T polymorphism may be associated with Crohn's Disease risk.

  2. We performed analyses of the IL-6 (show IL6 Proteins) 572C/G and 174G/C SNPs as well as the IL-10 592A/C and 1082G/A SNPs.The IL-10-1082 AG genotype was significantly higher in the case group (26.22%) versus the control group (11.67%); whereas the AA genotype was lower in the case group (73.78%) versus the control group

  3. Lower IL-10 receptor affinity.

  4. The purpose of this study was to evaluate the relationship of functional single-nucleotide polymorphisms (SNPs) in cytokine gene and cytokine expression levels with AML.Our results suggest that functional variants of the TNF-alpha (show TNF Proteins), IL-10, and TGF-beta1 (show TGFB1 Proteins) genes may have a significant association with the etiopathogenesis of AML (show RUNX1 Proteins).

  5. There was no evidence of associations between gene promoter polymorphisms of IL-10 and periportal fibrosis regression after treatment.

  6. this review discusses the factors driving IL-10 production and the cellular sources of the cytokine during antiviral immune responses, with particular focus on the IL-10 regulatory mechanisms that impact antiviral immune responses, and how viruses can use this central regulatory pathway to evade immunity and establish chronic/latent infections

  7. There was a significant direct correlation between levels of IL-10 and IL-22 (show IL22 Proteins) in patients group (p=0.0005). The clinical severity of psoriasis was significantly correlated with high levels of IL-22 (show IL22 Proteins) (p<0.0001).

  8. Data suggest that the IL-10/TGF-beta (show TGFB1 Proteins) pathway could be a target for early inhibition to facilitate Mycobacterium tuberculosis (Mtb (show NCAPG2 Proteins)) clearance.

  9. this study shows that epimer aspirin-triggered RvD1 reduced the concentration of IL-10 in PBMCs from patients with severe asthma

  10. this paper shows that IL-10 plays a central role in regulating the production of cytokines induced by hepatitis C virus core protein and polyI:C.

Mouse (Murine) Interleukin 10 (IL10) interaction partners

  1. this paper shows that the ability of pVAXhsp65 vaccination to control experimental autoimmune encephalomyelitis development is associated with IL-10 induction

  2. Ellagic acid treatment augmented specific IL-10 production in response to S. mansoni antigenic stimulation. However, specific IL-1beta (show IL1B Proteins), IL-4 (show IL4 Proteins), IL-12 (show IL12A Proteins), IL-13 (show IL13 Proteins), IL-17A (show IL17A Proteins), TNF-alpha (show TNF Proteins) and IFN-gamma (show IFNG Proteins) production were significantly reduced with ex vivo and in vivo ellagic acid treatment.

  3. this study shows that SIRT1 (show SIRT1 Proteins)-AMPK (show PRKAA1 Proteins)-autophagy pathway may be involved in the maintenance of chronic inflammation and dysplasia development in the IL-10-deficient mice model

  4. IL-10 abrogation efficiently induces regulatory T cell (Treg) formation but dampens tumoral neuropilin-1 (Nrp-1 (show NRP1 Proteins)) Treg signaling, which simultaneously augments Th1 (show HAND1 Proteins) and Th17 immunity.

  5. After Mycobacterium tuberculosis infection, TNF-alpha (show TNF Proteins) and IL-10 levels, alveolar macrophage apoptosis, and STAT3 (show STAT3 Proteins) and p-STAT3 (show STAT3 Proteins) expression increased significantly on days 1, 3, and 7 (P < 0.05), with maximum values on day 3.

  6. It has been demonstrated that beta-endorphin (show POMC Proteins) stimulates the zymosan-induced secretion of reactive oxygen species and suppresses the spontaneous production of IL-1beta (show IL1B Proteins) and IL-10 by murine peritoneal macrophages in vivo.

  7. the degree of fibrosis, inflammatory cell infiltration, and the number of BM-derived myofibroblasts were significantly different between IL-10 KO BM and WT BM transplanted mice, highlighting a likely role of IL-10 in pancreatitis.

  8. CD26 (show DPP4 Proteins) costimulatory blockade promotes lung allograft acceptance via reduced T cell infiltration, less expression of IL-17 (show IL17A Proteins), and increased expression of IL-10, likely to be derived from alternatively activated macrophages.

  9. Lactobacillus curvatus WiKim38 induced significantly higher levels of IL-10 in bone marrow-derived dendritic cells.

  10. Light-emitting diode therapy increased the levels of IL-10 in a model of chronic inflammatory hyperalgesia

Cow (Bovine) Interleukin 10 (IL10) interaction partners

  1. This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.

  2. IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.

  3. Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (show TLR4 Proteins) like receptor activation.

  4. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (show SOCS3 Proteins), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Horse (Equine) Interleukin 10 (IL10) interaction partners

  1. The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.

  2. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Proteins) biased, interferon-gamma (show IFNG Proteins) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.

  3. serum IL-6 (show IL6 Proteins):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia

  4. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (show IL6 Proteins), IL-10 and TNF-alpha (show TNF Proteins), in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Guinea Pig Interleukin 10 (IL10) interaction partners

  1. The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.

Rabbit Interleukin 10 (IL10) interaction partners

  1. ICAM1 (show ICAM1 Proteins) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (show JUN Proteins) may be responsible for this upregulation.

Pig (Porcine) Interleukin 10 (IL10) interaction partners

  1. These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.

  2. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Proteins), IL-10, and IL-6 (show IL6 Proteins) in ovarian follicles are reported.

  3. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (show IFNG Proteins)+CD4 (show CD4 Proteins)+ regulatory T cells to control transplant arteriosclerosis.

  4. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (show MAPK14 Proteins) activation.

  5. Boar seminal plasma contained TGF- beta1 (show TGFB1 Proteins) and IL-10 but with high individual variation.

  6. Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.

  7. These results suggest that TNF-alpha (show TNF Proteins) and IL-10, but not IL-6 (show IL6 Proteins), are involved in the late reparatory phases of the experimental disk lesion.

  8. The present study shows that elevated levels of serum CRP (show CRP Proteins) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)

  9. Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.

  10. Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping.

Rhesus Monkey Interleukin 10 (IL10) interaction partners

  1. IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (show NTS Proteins), which may contribute to differences in the clinical presentation of NTS (show NTS Proteins) infection in the setting of malaria.

  2. Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.

  3. IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (show TNF Proteins) cytokine production.

IL-10 (IL10) Protein Profile

Protein Summary

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Alternative names and synonyms associated with IL-10 (IL10)

  • interleukin 10 (IL10)
  • interleukin 10 (Il10)
  • CSIF protein
  • GVHDS protein
  • Il-10 protein
  • IL10A protein
  • IL10X protein
  • TGIF protein

Protein level used designations for Interleukin 10 Proteins (IL10)

T-cell growth inhibitory factor , cytokine synthesis inhibitory factor , interleukin-10 , CSIF , IL-10 , uncharacterized protein LOC100715618 , Cytokine synthesis inhibitory factor , Interleukin-10

GENE ID SPECIES
3586 Homo sapiens
16153 Mus musculus
25325 Rattus norvegicus
281246 Bos taurus
100034187 Equus caballus
443342 Ovis aries
403628 Canis lupus familiaris
428264 Gallus gallus
100860746 Capra hircus
100715618 Cavia porcellus
100008701 Oryctolagus cuniculus
397106 Sus scrofa
493683 Felis catus
694931 Macaca mulatta
100386149 Callithrix jacchus
469657 Pan troglodytes
101271889 Orcinus orca
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