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Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN1305113
Matsushima, Oppenheim: Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF. in Cytokine 1991
Show all 2 Pubmed References
Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN624491
Leyh, Seitz, Dürselen, Schaumburger, Ignatius, Grifka, Grässel: Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. in Arthritis research & therapy 2015
Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN413549
Reeves, Williamson, ONeill, Greally, McElvaney: Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis. in American journal of respiratory and critical care medicine 2011
gene expression and epistasis analysis indicated that CXCL8(IL-8) was a functional target of vitamin D3-mediated HSPC (show PSMA7 Proteins) regulation. Together, these findings highlight the relevance of developmental 1,25(OH)D3 availability for definitive hematopoiesis and suggest potential therapeutic utility in HSPC (show PSMA7 Proteins) expansion
Targeted expression of the human oncogene (show RAB1A Proteins) KRASG12V in zebrafish gills induces inflammation and cxcl8-l1 expression.
Data show that both Cxcl8-l1 and Cxcl8-l2 are required for larva survival upon Salmonella Typhimurium infection.
results explain how early H2O2 signal regulates neutrophil recruitment at all phases, directly via Lyn (show LYN Proteins) oxidation or indirectly by modulating cxcl8 gene expression
The data identify HOXC9 (show HOXC9 Proteins) as an endothelial cell active transcriptional repressor promoting the resting, antiangiogenic endothelial cell phenotype in an interleukin 8-dependent manner
Here, we report the characterisation of genes encoding the zebrafish Cxcl8, Cxcr1 (show CXCR1 Proteins) and Cxcr2 (show CXCR2 Proteins)
this study shows that ponciretin may attenuate ethanol-induced gastritis via the regulation of IL-8 secretion
Adh (show AVP Proteins) binds to OR5M11, which enhances Actinobacillus pleuropneumoniae pathogenicity by activating p38 (show CRK Proteins) which induces apoptosis of PAMs and IL-8 release
Findings suggest that IL8-dependent osteoclast activation may constitute an early event in the initiation of the joint specific inflammation in anti-citrullinated protein-positive rheumatoid arthritis.
Data suggest that CXCL1 (show CXCL1 Proteins)/IL-8, released from osteoclasts in an autoantibody-dependent manner, produces pain by activating sensory neurons.
IL-8 signaling is up-regulated in alcoholic hepatitis.
expressions of IL-1beta (show IL1B Proteins) and IL-8 in the brain increased after ApoE (show APOE Proteins) knockout in mice
CYLD (show CYLD Proteins) negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via MKP-1 (show DUSP1 Proteins)-dependent inhibition of ERK (show EPHB2 Proteins).
Taken together, these results indicate that CD147 promotes lung cancer-induced osteoclastogenesis by modulating IL-8 secretion, and suggest that CD147 is a potential therapeutic target for cancer-associated bone resorption in lung cancer patients.
these data outline a novel role for the P2Y6 receptor (show P2RY6 Proteins) in the induction of CXCL8/IL-8 production and barrier dysfunction in response to C. difficile toxin exposure and may provide a new therapeutic target for the treatment of CDI.
these data suggest that IL-8 plays an important role in breast cancer osteolysis
p300 (show EP300 Proteins)-dependent histone H3 (show HIST3H3 Proteins) acetylation and C/EBPbeta (show CEBPB Proteins)-regulated IKKbeta (show IKBKB Proteins) expression contribute to thrombin (show F2 Proteins)-induced IL-8/CXCL8 expression in human lung epithelial cells.
IL-17 (show IL17A Proteins) and TNF-alpha (show TNF Proteins) induced IL-6 (show IL6 Proteins) and IL-8 expression, although IL-17 (show IL17A Proteins) alone had a limited effect on endothelial cells compared to synoviocytes. Supernatants from activated T-helper clones also induced IL-6 (show IL6 Proteins) and IL-8 expression but with discrepancies between endothelial cells and synoviocytes.
Relationship of inflammatory profile of elderly patients serum and senescence-associated secretory phenotype with human breast cancer cells proliferation: Role of IL6 (show IL6 Proteins)/IL8 ratio.(
the increased levels of IL-6 (show IL6 Proteins), IL-8 and TNF-alpha (show TNF Proteins) in serum of multiple sclerosis (MS) patients compared to healthy controls, support the use of multiple cytokines for future MS biomarker and disease progression research.
in the presence of autologous platelets, monocytes from older adults synthesized greater IL-8 than younger adults
The mo-DCs from HIV-1 infected patients depicted functional exhaustion as evident by decreased allo-stimulation index (mean+/-SD: 10+/-6 vs. 24+/-16) (p<0.05), decreased cytokine production (pg/ml) (IL-12 (show IL12A Proteins): 4.6+/-16 vs. 25+/-85; TNF-alpha (show TNF Proteins): 128+/-279 vs. 286+/-544; IL-10 (show IL10 Proteins): 6+/-12 vs. 13+/-20; IL-8: 10,688+/-11,748 vs. 17,470+/-125,049) and retained endocytosis (1.1+/-0.3 vs. 1.0+/-0.29) (p<0.05) even after LPS (show IRF6 Proteins)-stimu...
Interaction of Monomeric Interleukin-8 with CXCR1 (show CXCR1 Proteins)
lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8. Notably, both genera also lowered the TSLP (show TSLP Proteins) expression in stimulated Caco-2 cells, regardless of the diet regimen.
The serum levels of IL-8, MIP-1 alpha (show CCL3 Proteins), MIP-1 beta (show CCL4 Proteins), MMP-8 (show MMP8 Proteins), Resistin (show RETN Proteins), FLRG (show FSTL3 Proteins), and BCAM (show BCAT2 Proteins) were significantly higher in breast cancer patients, but LAP and TSH-beta (show TSHB Proteins) levels were lower.
Oral and periodontal innate immunity is affected by HIV viremia and ART. GCF (show GUCY2F Proteins) IL-8, G-CSF (show CSF3 Proteins), as well as serum IL-8, MCP-1 (show CCL2 Proteins) and GM-CSF (show CSF2 Proteins) may be useful biomarkers for the detection of disease presence and/or its severity due to HIV infection and ART use.
Molecular characterization of the bovine IER3 (show IER3 Proteins) gene: Down-regulation of IL-8 by blocking NF-kappaB (show NFKB1 Proteins) activity mediated by IER3 (show IER3 Proteins) overexpression in MDBK cells infected with bovine viral diarrhea virus-1.
STA3 (show ARHGEF3 Proteins) facilitates TLR4 (show TLR4 Proteins)-dependent IL-6 (show IL6 Proteins) and IL-8 production via IL-6 (show IL6 Proteins) receptor-positive feedback in endometrial cells.
As a pilot study, the present results revealed that identified SNPs in IL8 and TLR4 (show TLR4 Proteins) genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 (show TLR4 Proteins) gene may be a potential candidate for such disease.
Blood levels of cortisol, immunoglobulin G, and IL-8 in relationship to genetics and the incidence of bovine respiratory complex disease are reported.
Genetic variation at the IL8 locus explains a proportion of the inter-breed and inter-individual variation in immunity between neonatal calves which is likely to influence their resistance to infection.
In response to C. abortus infection, both ovine and bovine turbinate cells produce CXCL8 mRNA and protein late in the bacterial developmental cycle.
Studied association of IL8 -105G/A with mastitis somatic cell score in Chinese Holstein dairy cows. Results suggest genotype GG may be a useful genetic marker for mastitis resistance selection and breeding in Chinese Holstein dairy cows.
Data implicate a complex cascade of events during luteolysis, involving Il8 signaling, neutrophil recruitment, and immune cell action within the corpus luteum.
Cadmium exposure induced pulmonary inflammation and increased lung interleukin 8 secretion.
Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.
The JNK (show MAPK8 Proteins)-activated AP-1 (show JUN Proteins) subunit c-Jun (show JUN Proteins) was critical for the up-regulation of IL-8 expression by PRRSV
These results suggest that porcine circovirus 2 induces IL-8 secretion via the TLR2/MyD88 (show MYD88 Proteins)/NF-kappaB (show NFKB1 Proteins) signalling pathway.
Facilitated degradation of the RGS16 (show RGS16 Proteins) by porcine circovirus type 2 ORF3 further enhances NFkappaB translocation into the nucleus through the ERK1/2 signalling pathway and increased IL-6 (show IL6 Proteins) and IL-8 mRNA transcripts.
Suggest that the interplay between TGFbeta (show TGFB1 Proteins)-2 and LPS (show IRF6 Proteins) regulates the levels of IL-8 in the immature newborn intestine.
Data suggest that MSK1 (show RPS6KA5 Proteins) and MSK2 are the major CREB (show CREB1 Proteins) kinases in fibroblast-like synoviocytes from rheumatoid arthritis patients stimulated with lysophosphatidic acid and that phosphorylation of CREB1 (show CREB1 Proteins) at Ser (show SIGLEC1 Proteins)-133 plays a significant role in IL-8 production.
Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (show IL1B Proteins), IL-8 and TNF-alpha (show TNF Proteins) in porcine alveolar macrophages.
local expression of IL-1beta (show IL1B Proteins) and IL-8 in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls
In swine, IL-8, TNF-ALPHA (show TNF Proteins), INOS (show NOS2 Proteins) AND MIP-1BETA (show CCL4 Proteins) were increased during mechanical ventilation in a time-related fashion.
Classical swine fever virus NS2 protein promotes interleukin-8 expression.
Developmental changes in IL-8 isoforms may serve to minimize its inflammatory effects in the fetus and also provide a mechanism to restore its full activity after birth
At the 2-wk time point, interleukin 8 gene expression was comparable in intervertebral discs injected with chondrocytes in controls, whereas its expression in IVDs injected with saline increased 50-fold
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1 (show CCL2 Proteins)) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.
The JNK (show MAPK8 Proteins) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha (show TNF Proteins) expression in alveolar macrophages, but the injury-stimulated IL-8 expression may be regulated by other signaling pathways.
IL-8 and IL-1ra (show IL1RN Proteins) showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis
Results suggested that chemokine (show CCL1 Proteins) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.
Mapped six genes (EIF4G3 (show EIF4G3 Proteins), HSP90 (show HSP90AB1 Proteins), RBBP6 (show RBBP6 Proteins), IL8, TERT (show TERT Proteins), and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization.
This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Proteins) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
These results suggest that MMP-1 (show MMP1 Proteins) and IL-8 are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.
Stress decreased IL-8 gene expression in both CeA (show CEACAM3 Proteins) lesioned and non-lesioned animals. But, CeA (show CEACAM3 Proteins) lesions increased the tissue expression of IL-8 mRNA prior to and after stress exposure.
Duck IL-8 is good immunostimulant to enhance the immune efficiency of avian influenza vaccine in ducks.
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.
CXC chemokine K60
, interleukin 8
, C-X-C motif chemokine 15
, small inducible cytokine subfamily B, member 15
, small-inducible cytokine B15
, T-cell chemotactic factor
, alveolar macrophage chemotactic factor I
, beta endothelial cell-derived neutrophil activating peptide
, beta-thromboglobulin-like protein
, chemokine (C-X-C motif) ligand 8
, granulocyte chemotactic protein 1
, lung giant cell carcinoma-derived chemotactic protein
, lymphocyte derived neutrophil activating peptide
, monocyte-derived neutrophil chemotactic factor
, monocyte-derived neutrophil-activating peptide
, neutrophil-activating peptide 1
, small inducible cytokine subfamily B, member 8
, tumor necrosis factor-induced gene 1
, C-X-C motif chemokine 8
, neutrophil activating peptide 1
, alveolar macrophage-derived chemotactic factor-I
, neutrophil attractant/activation protein 1
, neutrophil attractant/activation protein-1
, permeability factor 1
, Interleukin-8-like protein
, Neutrophil attractant protein 1
, neutrophil attractant protein-1
, CEF-4/9E3 cytokine
, RSV-induced protein
, embryo fibroblast protein 1
, putatitve interleukin-8
, transformation-induced protein