Browse our Interleukin 8 Proteins (IL8)

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Interleukin 8 Proteins (IL8)
On are 179 Interleukin 8 (IL8) Proteins from 24 different suppliers available. Additionally we are shipping Interleukin 8 Antibodies (558) and Interleukin 8 Kits (187) and many more products for this protein. A total of 952 Interleukin 8 products are currently listed.
AMCF-I, CXCL8, cxcli2, EMF-1, GCP-1, GCP1, IL-8, Il8, interleukin-8, K60, LECT, LUCT, lungkine, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, Scyb15, si:dkey-151b16.2, weche
list all proteins Gene Name GeneID UniProt
IL8 20309 Q9WVL7
IL8 3576 P10145

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Interleukin 8 Proteins (IL8) by Origin

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Top referenced Interleukin 8 Proteins

  1. Dog (Canine) Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN2008844 : Koch, Polverini, Kunkel, Harlow, DiPietro, Elner, Elner, Strieter: Interleukin-8 as a macrophage-derived mediator of angiogenesis. in Science (New York, N.Y.) 1993 (PubMed)
    Show all 5 references for 2008844

  2. Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN2002054 : Bar-Eli: Role of interleukin-8 in tumor growth and metastasis of human melanoma. in Pathobiology : journal of immunopathology, molecular and cellular biology 1999 (PubMed)
    Show all 5 references for 2002054

  3. Human Interleukin 8 Protein expressed in Human Cells - ABIN2002051 : Baggiolini, Clark-Lewis: Interleukin-8, a chemotactic and inflammatory cytokine. in FEBS letters 1992 (PubMed)
    Show all 5 references for 2002051

  4. Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN2667543 : Hess, Means, Autissier, Woodberry, Altfeld, Addo, Frahm, Brander, Walker, Luster: IL-8 responsiveness defines a subset of CD8 T cells poised to kill. in Blood 2004 (PubMed)
    Show all 4 references for 2667543

  5. Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN2666581 : Drewniak, Tool, Geissler, van Bruggen, van den Berg, Kuijpers: Toll-like receptor-induced reactivity and strongly potentiated IL-8 production in granulocytes mobilized for transfusion purposes. in Blood 2010 (PubMed)
    Show all 4 references for 2666581

  6. Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN1305113 : Matsushima, Oppenheim: Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF. in Cytokine 1991 (PubMed)
    Show all 2 references for 1305113

  7. Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN1047264 : Van Damme, Rampart, Conings, Decock, Van Osselaer, Willems, Billiau: The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. in European journal of immunology 1990 (PubMed)
    Show all 2 references for 1047264

  8. Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN413549 : Reeves, Williamson, ONeill, Greally, McElvaney: Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis. in American journal of respiratory and critical care medicine 2011 (PubMed)

  9. Rhesus Monkey Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN2010090 : Utgaard, Jahnsen, Bakka, Brandtzaeg, Haraldsen: Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells. in The Journal of experimental medicine 1998 (PubMed)

More Proteins for Interleukin 8 Interaction Partners

Zebrafish Interleukin 8 (IL8) interaction partners

  1. Targeted expression of the human oncogene (show RAB1A Proteins) KRASG12V in zebrafish gills induces inflammation and cxcl8-l1 expression.

  2. Data show that both Cxcl8-l1 and Cxcl8-l2 are required for larva survival upon Salmonella Typhimurium infection.

  3. results explain how early H2O2 signal regulates neutrophil recruitment at all phases, directly via Lyn (show LYN Proteins) oxidation or indirectly by modulating cxcl8 gene expression

  4. The data identify HOXC9 (show HOXC9 Proteins) as an endothelial cell active transcriptional repressor promoting the resting, antiangiogenic endothelial cell phenotype in an interleukin 8-dependent manner

  5. Here, we report the characterisation of genes encoding the zebrafish Cxcl8, Cxcr1 (show CXCR1 Proteins) and Cxcr2 (show CXCR2 Proteins)

Mouse (Murine) Interleukin 8 (IL8) interaction partners

  1. this study shows that ponciretin may attenuate ethanol-induced gastritis via the regulation of IL-8 secretion

  2. Adh (show AVP Proteins) binds to OR5M11, which enhances Actinobacillus pleuropneumoniae pathogenicity by activating p38 (show CRK Proteins) which induces apoptosis of PAMs and IL-8 release

  3. Findings suggest that IL8-dependent osteoclast activation may constitute an early event in the initiation of the joint specific inflammation in anti-citrullinated protein-positive rheumatoid arthritis.

  4. Data suggest that CXCL1 (show CXCL1 Proteins)/IL-8, released from osteoclasts in an autoantibody-dependent manner, produces pain by activating sensory neurons.

  5. IL-8 signaling is up-regulated in alcoholic hepatitis.

  6. expressions of IL-1beta (show IL1B Proteins) and IL-8 in the brain increased after ApoE (show APOE Proteins) knockout in mice

  7. CYLD (show CYLD Proteins) negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via MKP-1 (show DUSP1 Proteins)-dependent inhibition of ERK (show EPHB2 Proteins).

  8. Taken together, these results indicate that CD147 (show BSG Proteins) promotes lung cancer-induced osteoclastogenesis by modulating IL-8 secretion, and suggest that CD147 (show BSG Proteins) is a potential therapeutic target for cancer-associated bone resorption in lung cancer patients.

  9. these data outline a novel role for the P2Y6 receptor (show P2RY6 Proteins) in the induction of CXCL8/IL-8 production and barrier dysfunction in response to C. difficile toxin exposure and may provide a new therapeutic target for the treatment of CDI.

  10. these data suggest that IL-8 plays an important role in breast cancer osteolysis

Human Interleukin 8 (IL8) interaction partners

  1. Patients with mixed dyslipidaemia have higher plasma VEGF (show VEGFA Proteins) levels. Rosuvastatin, either as monotherapy or at a lower dose in combination with -3 PUFAs significantly reduces IL-8 levels.

  2. Results identified two haplotypes in IL8 associated with the development of age-related macular degeneration which was confirmed in two independent sample cohorts.

  3. associations between the genetic variants and the LPS (show IRF6 Proteins)-induced IL-6 (show IL6 Proteins), IL-8, IL-10 (show IL10 Proteins), IL-1ra (show IL1RN Proteins) and TNF-alpha (show TNF Proteins) cytokine levels were not significant in the meta-analysis. This present study does not support a strong genetic effect of LPS (show IRF6 Proteins)-stimulated cytokine production; however, the potential for type II errors should be considered

  4. IL-6 (show IL6 Proteins), IL-8 and TNF-alpha (show TNF Proteins) levels correlated with clinical disease stage.

  5. High levels of IL-6 (show IL6 Proteins) and IL-8 were observed in children with aplastic anemia. Increased levels showed correlation with disease severity; however, levels had no significant correlation with the treatment outcome.

  6. Results indicate overexpressed HMGB1 (show HMGB1 Proteins) contributes to gastric tumor angiogenesis through IL-8 mediation.

  7. Interleukin-1alpha induces release of interleukin-8 by human bronchial epithelial cells

  8. miR (show MLXIP Proteins)-146a, miR (show MLXIP Proteins)-146b, and miR (show MLXIP Proteins)-155 are exerting anti-inflammatory properties by down-regulating IL-6 (show IL6 Proteins) and IL-8, and influencing the expression of HSP10 (show HSPE1 Proteins) in the activated endothelium

  9. These data suggest that, without infection, inactivated-H5N1 induces mRNA expression of IL-6 (show IL6 Proteins) and CXCL8 by a mechanism, or mechanisms, requiring interaction between viral hemagglutinin (show HA Proteins) and alpha-2,3 sialic acid receptors at the cell membrane of host cells, and involves activation of P2Y6 (show P2RY6 Proteins) purinergic receptors.

  10. higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor (show ESR1 Proteins) negativity was associated with significantly shorter overall survival.

Cow (Bovine) Interleukin 8 (IL8) interaction partners

  1. As a pilot study, the present results revealed that identified SNPs in IL8 and TLR4 (show TLR4 Proteins) genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 (show TLR4 Proteins) gene may be a potential candidate for such disease.

  2. Blood levels of cortisol, immunoglobulin G, and IL-8 in relationship to genetics and the incidence of bovine respiratory complex disease are reported.

  3. Genetic variation at the IL8 locus explains a proportion of the inter-breed and inter-individual variation in immunity between neonatal calves which is likely to influence their resistance to infection.

  4. In response to C. abortus infection, both ovine and bovine turbinate cells produce CXCL8 mRNA and protein late in the bacterial developmental cycle.

  5. Studied association of IL8 -105G/A with mastitis somatic cell score in Chinese Holstein dairy cows. Results suggest genotype GG may be a useful genetic marker for mastitis resistance selection and breeding in Chinese Holstein dairy cows.

  6. Data implicate a complex cascade of events during luteolysis, involving Il8 signaling, neutrophil recruitment, and immune cell action within the corpus luteum.

  7. Cadmium exposure induced pulmonary inflammation and increased lung interleukin 8 secretion.

  8. Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

  9. study demonstrates that a small experimental rodent model can be utilized for non-invasively monitoring, through a reporter gene system, the activation of an IL-8 promoter region derived from a larger size animal (bovine)

  10. Finding of genetic variation in the IL8 promoter that differentially regulates its expression has significant functional implications for IL8 expression in vitro and which may impact on susceptibility to infectious disease and inflammation.

Pig (Porcine) Interleukin 8 (IL8) interaction partners

  1. The JNK (show MAPK8 Proteins)-activated AP-1 (show JUN Proteins) subunit c-Jun (show JUN Proteins) was critical for the up-regulation of IL-8 expression by PRRSV

  2. These results suggest that porcine circovirus 2 induces IL-8 secretion via the TLR2/MyD88 (show MYD88 Proteins)/NF-kappaB (show NFKB1 Proteins) signalling pathway.

  3. Facilitated degradation of the RGS16 (show RGS16 Proteins) by porcine circovirus type 2 ORF3 further enhances NFkappaB translocation into the nucleus through the ERK1/2 signalling pathway and increased IL-6 (show IL6 Proteins) and IL-8 mRNA transcripts.

  4. Suggest that the interplay between TGFbeta (show TGFB1 Proteins)-2 and LPS (show IRF6 Proteins) regulates the levels of IL-8 in the immature newborn intestine.

  5. Data suggest that MSK1 (show RPS6KA5 Proteins) and MSK2 are the major CREB (show CREB1 Proteins) kinases in fibroblast-like synoviocytes from rheumatoid arthritis patients stimulated with lysophosphatidic acid and that phosphorylation of CREB1 (show CREB1 Proteins) at Ser (show SIGLEC1 Proteins)-133 plays a significant role in IL-8 production.

  6. Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (show IL1B Proteins), IL-8 and TNF-alpha (show TNF Proteins) in porcine alveolar macrophages.

  7. local expression of IL-1beta (show IL1B Proteins) and IL-8 in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls

  8. In swine, IL-8, TNF-ALPHA (show TNF Proteins), INOS (show NOS2 Proteins) AND MIP-1BETA (show CCL4 Proteins) were increased during mechanical ventilation in a time-related fashion.

  9. Classical swine fever virus NS2 protein promotes interleukin-8 expression.

  10. Developmental changes in IL-8 isoforms may serve to minimize its inflammatory effects in the fetus and also provide a mechanism to restore its full activity after birth

Rabbit Interleukin 8 (IL8) interaction partners

  1. At the 2-wk time point, interleukin 8 gene expression was comparable in intervertebral discs injected with chondrocytes in controls, whereas its expression in IVDs injected with saline increased 50-fold

  2. Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1 (show CCL2 Proteins)) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.

  3. The JNK (show MAPK8 Proteins) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha (show TNF Proteins) expression in alveolar macrophages, but the injury-stimulated IL-8 expression may be regulated by other signaling pathways.

  4. IL-8 and IL-1ra (show IL1RN Proteins) showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis

Horse (Equine) Interleukin 8 (IL8) interaction partners

  1. Results suggested that chemokine (show CCL1 Proteins) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.

  2. Mapped six genes (EIF4G3 (show EIF4G3 Proteins), HSP90 (show HSP90AB1 Proteins), RBBP6 (show RBBP6 Proteins), IL8, TERT (show TERT Proteins), and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization.

  3. This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Proteins) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

  4. These results suggest that MMP-1 (show MMP1 Proteins) and IL-8 are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.

Rhesus Monkey Interleukin 8 (IL8) interaction partners

  1. Stress decreased IL-8 gene expression in both CeA (show CEACAM3 Proteins) lesioned and non-lesioned animals. But, CeA (show CEACAM3 Proteins) lesions increased the tissue expression of IL-8 mRNA prior to and after stress exposure.

Duck Interleukin 8 (IL8) interaction partners

  1. Duck IL-8 is good immunostimulant to enhance the immune efficiency of avian influenza vaccine in ducks.

Interleukin 8 (IL8) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.

Alternative names and synonyms associated with Interleukin 8 (IL8)

  • interleukin 8-like 1 (IL8L1)
  • interleukin 8 (il8)
  • interleukin 8 (IL8)
  • chemokine (C-X-C motif) ligand 1-like (LOC422654)
  • chemokine (C-X-C motif) ligand 15 (Cxcl15)
  • interleukin 8 (Il8)
  • interleukin 8-like 2 (IL8L2)
  • interleukin-8-like (IL*08-02)
  • AMCF-I protein
  • CXCL8 protein
  • cxcli2 protein
  • EMF-1 protein
  • GCP-1 protein
  • GCP1 protein
  • IL-8 protein
  • Il8 protein
  • interleukin-8 protein
  • K60 protein
  • LECT protein
  • LUCT protein
  • lungkine protein
  • LYNAP protein
  • MDNCF protein
  • MONAP protein
  • NAF protein
  • NAP-1 protein
  • NAP1 protein
  • Scyb15 protein
  • si:dkey-151b16.2 protein
  • weche protein

Protein level used designations for Interleukin 8 Proteins (IL8)

CXC chemokine K60 , interleukin 8 , interleukin-8 , cxcl-chr1b , cxcl8 , IL-8 , C-X-C motif chemokine 15 , small inducible cytokine subfamily B, member 15 , small-inducible cytokine B15 , T-cell chemotactic factor , alveolar macrophage chemotactic factor I , beta endothelial cell-derived neutrophil activating peptide , beta-thromboglobulin-like protein , chemokine (C-X-C motif) ligand 8 , emoctakin , granulocyte chemotactic protein 1 , lung giant cell carcinoma-derived chemotactic protein , lymphocyte derived neutrophil activating peptide , monocyte-derived neutrophil chemotactic factor , monocyte-derived neutrophil-activating peptide , neutrophil-activating peptide 1 , small inducible cytokine subfamily B, member 8 , tumor necrosis factor-induced gene 1 , C-X-C motif chemokine 8 , neutrophil activating peptide 1 , alveolar macrophage-derived chemotactic factor-I , NAP-1 , PF1 , RPF1 , neutrophil attractant/activation protein 1 , neutrophil attractant/activation protein-1 , permeability factor 1 , Interleukin-8-like protein , Neutrophil attractant protein 1 , neutrophil attractant protein-1 , interlukin-8 , 9E3 , CEF-4 , CEF-4/9E3 cytokine , RSV-induced protein , embryo fibroblast protein 1 , putatitve interleukin-8 , transformation-induced protein , Anpl-IL*08-03

395872 Gallus gallus
445923 Takifugu rubripes
471205 Pan troglodytes
100002946 Danio rerio
100034742 Meleagris gallopavo
100381196 Papio anubis
422654 Gallus gallus
20309 Mus musculus
3576 Homo sapiens
280828 Bos taurus
443418 Ovis aries
396880 Sus scrofa
403850 Canis lupus familiaris
100009129 Oryctolagus cuniculus
100037400 Equus caballus
100379599 Cavia porcellus
493836 Felis catus
613028 Macaca mulatta
101441641 Dasypus novemcinctus
101331085 Tursiops truncatus
396495 Gallus gallus
101804010 Anas platyrhynchos
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