Browse our IRF8 Proteins (IRF8)

Full name:
Interferon Regulatory Factor 8 Proteins (IRF8)
On www.antibodies-online.com are 12 Interferon Regulatory Factor 8 (IRF8) Proteins from 6 different suppliers available. Additionally we are shipping IRF8 Antibodies (103) and IRF8 Kits (7) and many more products for this protein. A total of 130 IRF8 products are currently listed.
Synonyms:
AI893568, DKFZp469B0320, H-ICSBP, ICSBP, Icsbp1, IRF-8, IRF8, MGC140338, Myls, zgc:92252
list all proteins Gene Name GeneID UniProt
IRF8 3394 Q02556
IRF8 15900 P23611
Rat IRF8 IRF8 292060  

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IRF8 Proteins (IRF8) by Origin

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More Proteins for IRF8 Interaction Partners

Zebrafish Interferon Regulatory Factor 8 (IRF8) interaction partners

  1. The vertical and paralleled Pu.1/Spi-b (show SPIB Proteins) regulatory networks control the development of rostral blood island and ventral wall of dorsal aorta-borne macrophages by regulating Irf8.

  2. Study reveals that specification of all macrophages requires irf8 during an early period of zebrafish hematopoiesis but not during the adult-phase. Also, Irf8 seems to have essential roles in host defense as well.

  3. Irf8 is a critical determinant for neutrophil versus macrophage fate choice during zebrafish primitive myelopoiesis.

Human Interferon Regulatory Factor 8 (IRF8) interaction partners

  1. It findings provide evidence for an additional mechanism of epigenetic IRF8 silencing during osteoclastogenesis that likely works cooperatively with DNA methylation (show HELLS Proteins), further emphasizing the importance of IRF8 as a negative regulator of osteoclastogenesis.

  2. Data suggest that ubiquitin specific protease 4 (USP4 (show USP4 Proteins)) interacts with interferon regulatory factor 8 (IRF8) and, by its Lys48-specific deubiquitinase/endopeptidase activity, stabilizes IRF8 protein levels in regulatory T-lymphocytes; USP4 (show USP4 Proteins) and IRF8 are also expressed in helper T-lymphocytes.

  3. these data indicate that human NK cells require IRF8 for development and functional maturation and that dysregulation of this function results in severe human disease, thereby emphasizing a critical role for NK cells in human antiviral defense.

  4. down-regulation of IRF8 in the wound leads to impaired wound healing possibly through the regulation of macrophage function and apoptosis in skin wound.

  5. IRF8 may contribute to the genetic susceptibility of Behcet's disease by regulating IRF8 expression and cytokine production.

  6. IRF5 (show IRF5 Proteins) and IRF8, two transcription factors with opposing functions, control TLR9 (show TLR9 Proteins) signaling in human plasmacytoid dendritic cells.

  7. cytarabine-induced upregulation of the IRF8 in leukemic cells involves increased levels of ZNF224 (show ZNF224 Proteins), which can counteract the repressive activity of WT1 (show WT1 Proteins) on the IRF8-promoter

  8. Expression of WT1and IRF8 showed a moderate inverse correlation in acute myeloid leukemia (show BCL11A Proteins) patients. WT1 (show WT1 Proteins) can be used as an minimal residual disease marker, especially in patients without recurrent genetic abnormalities.

  9. Results show that IRF8 is a possible genetic variant associated with the development of HT and production of thyroid antibody

  10. The IRF8 gene variant influenced the interaction between IRF8 and NF-kappaB (show NFKB1 Proteins) and thus susceptibility to systemic sclerosis.

Mouse (Murine) Interferon Regulatory Factor 8 (IRF8) interaction partners

  1. Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.

  2. results show that polymorphonuclear-myeloid-derived suppressor cells arise from a newly defined granulocyte progenitors (GP) stage within the bone marrow and that IRF8 levels (and/or their downstream target genes) in those GPs guide their expansion or contraction

  3. IRF8 differentially controls the survival.

  4. IRF8 might play a role in restraining excess lymphocyte proliferation.

  5. IRF8 controls Th1 immune response in Treg cells independent of T-bet.

  6. The authors further identified a distinct molecular signature of F4/80(hi) and CD11b (show ITGAM Proteins)(hi) macrophages and found that Irf8 was vital for macrophage maturation.

  7. this study shows that myeloid-specific SIRT1 (show SIRT1 Proteins) restrains pro-inflammatory processes by deacetylating IRF8

  8. IRF8 was a target of miR (show MLXIP Proteins)-451a in vitro and in vivo. The data indicate the function and a target of miR (show MLXIP Proteins)-451a in SLE

  9. the mechanism for the observed differential induction of the mouse Ifit1 (show IFIT1 Proteins), Ifit2 (show IFIT2 Proteins), and Ifit3 genes in B cells and demonstrated that the repressive effect of the transcription factor interferon regulatory factor 8 (IRF8), which is highly expressed in B cells, played an essential role in this regulation.

  10. direct the expression of a set of genes, the IRF8/IRF1 (show IRF1 Proteins) regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively

IRF8 Protein Profile

Protein Summary

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.

Alternative names and synonyms associated with IRF8

  • interferon regulatory factor 8 (irf8)
  • interferon regulatory factor 8 (IRF8)
  • interferon regulatory factor 8 (LOC100350620)
  • interferon regulatory factor 8 (Irf8)
  • AI893568 protein
  • DKFZp469B0320 protein
  • H-ICSBP protein
  • ICSBP protein
  • Icsbp1 protein
  • IRF-8 protein
  • IRF8 protein
  • MGC140338 protein
  • Myls protein
  • zgc:92252 protein

Protein level used designations for IRF8

DKEYP-77B5.1 , interferon regulatory factor 8 , interferon regulatory factor 8-like , interferon consensus sequence binding protein 1 , interferon consensus sequence-binding protein , transcription factor ICSBP , IRF-8 , interferon consensus sequence binding protein

GENE ID SPECIES
436895 Danio rerio
454294 Pan troglodytes
489673 Canis lupus familiaris
614909 Bos taurus
693933 Macaca mulatta
100018105 Monodelphis domestica
100056218 Equus caballus
100173775 Pongo abelii
100350620 Oryctolagus cuniculus
100405221 Callithrix jacchus
100469809 Ailuropoda melanoleuca
100598495 Nomascus leucogenys
3394 Homo sapiens
446986 Xenopus laevis
15900 Mus musculus
292060 Rattus norvegicus
396385 Gallus gallus
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