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Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma.
Propose that degradation of MYC (show MYC ELISA Kits) limits the accumulation of MYC (show MYC ELISA Kits)/PAF1C complexes during transcriptional activation.
Mechanistic studies indicated that PAF1C could promote lung cancer cell proliferation through regulating c-MYC (show MYC ELISA Kits) transcription.
CNOT4 (show CNOT4 ELISA Kits) controls the degradation of chromatin-unbound PAF1 (show PEX2 ELISA Kits) via the 26S proteasome (show Psmd4 ELISA Kits).
this study found that Pol II-associated factor 1 (PAF1 (show PEX2 ELISA Kits)) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb (show CDK9 ELISA Kits)) directly regulates the initial recruitment of PAF1 (show PEX2 ELISA Kits) complex (PAF1C) to genes, and that the subsequent recruitment of CDK12 (show CRKRS ELISA Kits) is dependent on PAF1C.
This study reveals an evolutionarily conserved role for PAF1 (show PEX2 ELISA Kits) as a regulator of promoter-proximal pausing by RNA Pol II in all metazoans, including human.
PD2 is a novel cancer stem cell (CSC) maintenance protein, loss of which renders the CSCs more susceptible to drug-induced cell death.
Together, these results indicate that human adenovirus E1A (show BCKDHA ELISA Kits) uses hBre1 (show RNF20 ELISA Kits) to recruit the hPaf1 complex in order to optimally activate viral early transcription by enhancing transcriptional elongation.
The results show that the Paf1 (show PEX2 ELISA Kits)/Leo1 (show LEO1 ELISA Kits) heterodimer is necessary for its binding to histone H3 (show HIST3H3 ELISA Kits), the histone octamer, and nucleosome in vitro.
E1A (show BCKDHA ELISA Kits) changes the function of hBre1 (show RNF20 ELISA Kits) from a ubiquitin ligase involved in substrate selection to a scaffold which recruits hPaf1 as a means to stimulate transcription and transcription-coupled histone modifications.
link Paf1C with PolII elongation and RNA processing indicates that Paf1C subunits could play roles in controlling transcript length through suppression of PolII accumulation at transcription start site (TSS (show RPL38 ELISA Kits))-proximal pA sites
The PAF1 (show PEX2 ELISA Kits) complex is required for mammalian development, likely through regulation of H3K36me3, indicating a functional conservation of the PAF1 (show PEX2 ELISA Kits) complex from yeast to mammals in vivo.
As part of a cell-intrinsic transcriptional pathway, Paf1 (show PEX2 ELISA Kits) regulates neuronal migration in the brain.
MLL (show MLL ELISA Kits) interacts directly with the polymerase associated factor complex (PAFc) via Paf1 (show PEX2 ELISA Kits) and CTR9 (show CTR9 ELISA Kits). PAFc augments MLL (show MLL ELISA Kits) and MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits) mediated transcriptional activation of Hoxa9 (show HOXA9 ELISA Kits) and their interaction is essential for leukemogenesis.
show that Paf1/PD2 is overexpressed in mouse embryonic stem cells (ESCs (show NR2E3 ELISA Kits)) and is involved in the maintenance of mouse ESCs (show NR2E3 ELISA Kits).
The PAF1 complex differentially regulates cardiomyocyte specification.
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
RNA polymerase II-associated factor 1 homolog
, pancreatic differentiation protein 2
, PD2-like protein
, paf1, RNA polymerase II associated factor, homolog, like