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The effect of dobutamine as a positive inotrope is impaired in mice with cecal ligation and puncture-induced sepsis without changes in cardiac beta1-adrenoceptor signaling as a result of cAMP breakdown achieved by upregulated phosphodiesterase 4D
In vivo knockdown of (show FN1 ELISA Kits) PDE4D5 inhibited inflammation at athero-prone sites (show TWIST1 ELISA Kits)
Results indicate that the cyclic AMP (show TMPRSS5 ELISA Kits) (cAMP) increase is caused by the attenuation of phosphodiesterase (PDE (show TWIST1 ELISA Kits)) activity adrenal cortex-derived Y-1 cell line.
The authors demonstrate that the Attention Deficit Disorder with Hyperactivity phenotype depends on a dysregulation of CREB (show CREB1 ELISA Kits) signaling exerted by a kinase-independent PI3Kgamma (show PIK3CG ELISA Kits)-PDE4D interaction in the noradrenergic neurons of the locus coeruleus.
SIK1 (show SIK1 ELISA Kits) serves as a part of a self-regulatory circuit to modulate insulin (show INS ELISA Kits) secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D activity.
Cytokine-induced iNOS (show NOS2 ELISA Kits) and ERK1/2 (show MAPK1/3 ELISA Kits) inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle, contributing to colonic dysmotility during inflammation.
the loss of function of either DISC1 (show DISC1 ELISA Kits) or ATF4 (show ATF4 ELISA Kits) increases PDE4D9 transcription, and the association of DISC1 (show DISC1 ELISA Kits) with the PDE4D9 locus requires ATF4 (show ATF4 ELISA Kits)
these results suggest that Pde4d might serve specific biological functions in regulating the development process of the mouse embryo, and that CpG methylation of the Pde4d promoter may play an important role in regulating Pde4d at a transcriptional level.
Calcineurin regulates degradation of phosphodiesterase 3B, in addition to phosphodiesterase 4D.
Beta-arrestin-2 (show ARRB2 ELISA Kits) scaffolding of phosphodiesterase PDE4D5 to the plasma membrane was required for TRPV1 (show TRPV1 ELISA Kits) desensitization.
High PDE4D expression is associated with melanoma.
cells on fibronectin (show FN1 ELISA Kits) suppressed cAMP via enhanced phosphodiesterase (PDE (show ALDH7A1 ELISA Kits)) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5
we performed a meta-analysis of 15 studies, involving 8731 IS patients and 10,756 controls. The results showed nonsignificant association between PDE4D SNP56 and IS risk (T vs. A: OR=1.01, 95%CI=0.88-1.15, P=0.90). Similarly, in the subgroup analysis by ethnicity, no significant association was observed in Asian (T vs. A: OR=1.08, 95%CI=0.80-1.44, P=0.62) or European (T vs. A: OR=0.96, 95%CI=0.86-1.08, P=0.54) population.
RACK1 (show GNB2L1 ELISA Kits) and beta-arrestin2 (show ARRB2 ELISA Kits) inhibit the dimerization of PDE4D5.
PDE4D acts to allow cAMP-elevating agents to regulate VECADs' role as a sensor of flow-associated fluid shear stress (FSS)-encoded information in arterial endothelial cells.
PDE4D gene polymorphisms influence the susceptibility for the development of Sudden Sensorineural Hearing Loss in the southern Taiwanese female population.
focus on recent progress made in PDE4D gene research involving genetic and molecular aspects (review)
No association was found between single-nucleotide polymorphisms of ALOX5AP (show ALOX5AP ELISA Kits) or PDE4D and the risk of overall ischemic stroke in a southeastern Chinese population.
While prior studies have found an association between PDE4D and IL6R (show IL6R ELISA Kits) polymorphisms and ischemic stroke, the results of this study suggest that this association may be different in a hypertensive population.
This review show PDE4D mutation is a risk factor for atrial fibrillation and stroke.
demonstrate the presence of PDE4D transcript and protein, but also show an active enzyme, suggesting a functional role of PDE4D in bovine mammary gland
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
phosphodiesterase E3 dunce homolog, Drosophila
, phosphodiesterase 4D, cAMP-specific
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D-like
, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D
, cAMP-specific phosphodiesterase 4D
, cyclic AMP specific phosphodiesterase PDE4D5A
, cAMP-specific phosphodiesterase PDE4D6
, Phosphodiesterase 4D cAMP-specific (dunce
, Phosphodiesterase 4D, cAMP-specific (dunce
, cAMP-specific phosphodiesterase PDE4D
, cAMP-specific phosphodiesterase splice variant PDE4D8
, phosphodiesterase 4D, cAMP specific
, hypothetical protein