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Human Sphingomyelin Synthase 1 Protein expressed in Wheat germ - ABIN1319834
Lafont, Milhas, Carpentier, Garcia, Jin, Umehara, Okazaki, Schulze-Osthoff, Levade, Benoist, Ségui: Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death. in Cell death and differentiation 2010
SMS (show SMS Proteins) regulates the expression and function of drug transporters P-gp (show ABCB4 Proteins) and MRP2 (show ABCC2 Proteins).
HepG2 cells stably transfected with SMS1 (HepG2-SMS1) exhibit elevated enzyme activity in vitro and increased sphingomyelin content (mainly C22:0- and C24:0-sphingomyelin) but lower hexosylceramide (Hex (show HHEX Proteins)-Cer (show CBLN1 Proteins)) levels.
Sphingomyelin synthase 1 positively regulates KCNQ1 (show KCNQ1 Proteins)/KCNE1 (show KCNE1 Proteins) channel density in a protein kinase D (show PRKD1 Proteins)-dependent manner.
A study of the expression of the full-length SMS1 protein and the sum of the alternative transcripts encoding this protein in human tissues.
The structural organization of 5'-UTR variants of SGMS1 transcripts, directed by alternative promoters, is substantially different; this can provide regulation of the gene functioning on post-transcriptional level.
We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1), sphingomyelinase 3 (SMPD3 (show SMPD3 Proteins)), and glucosylceramide synthase (GCS (show UGCG Proteins)) in the endometrium of endometriotic women.
SGMS activity impacts on amyloid precursor protein (show APP Proteins) processing to produce amyloid-beta (Abeta (show APP Proteins)) and it could be a contributing factor in Abeta (show APP Proteins) pathology associated with Alzheimer's disease.
The amount of SMS1 transcripts varies considerably between different human tissues.
Findings indicate that Sms1 is a downstream target of Bcr-abl (show ABL1 Proteins), involved in sustaining cell proliferation of Bcr-abl (show ABL1 Proteins)-positive cells.
SMS1 and SMS2 (show SGMS2 Proteins) are capable of regulating TGN (show TG Proteins)-mediated protein trafficking and secretion
SMS1 has a wider than anticipated role in testis polyunsaturated fatty acid homeostasis and for male fertility
Sphingomyelin synthase 1 regulates Neuro-2a cell proliferation and cell cycle progression through modulation of p27 (show CDKN1B Proteins) expression and Akt (show AKT1 Proteins) signaling
study reveals that all mouse SMS family members (SMSr, SMS1, and SMS2) have CPE synthase activity
that SMS1 is crucial to control oxidative stress in order to maintain white adipose tissue function.
Defects in the stria vascularis with reductions in endocochlear potentials together with hair cell dysfunction may account, at least partially, for hearing impairments in SMS1-/- mice.
The deficiency of membrane sphingomyelin caused the CD4 (show CD4 Proteins) T-cell dysfunction through impaired lipid raft function contributing to protection of ConA-induced liver injury, and suggesting that the membrane sphingomyelin is critical for full T-cell activation.
Sms1 deficiency decreases sphingomyelin, but dramatically increases the levels of glycosphingolipids. Atherosclerosis in Sms1(-/-)-->Ldlr (show LDLR Proteins)(-/-) mice is significantly decreased.
SMS1 and SMS2 (show SGMS2 Proteins) play distinct roles in regulating local sphingomyelin clustering.
SMS1-mediated SM synthesis directs Tf-TfR to undergo clathrin-dependent endocytosis and recycling, promoting the proliferation of lymphoma cells.
SMS1 is important for controlling ROS (show ROS1 Proteins) generation, and SMS1 is required for normal mitochondrial function and insulin (show INS Proteins) secretion in pancreatic beta-cells
The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain.
phosphatidylcholine:ceramide cholinephosphotransferase 1
, sphingomyelin synthase 1
, phosphatidylcholine:ceramide cholinephosphotransferase 1-like
, medulla oblongata-derived protein
, protein Mob
, transmembrane protein 23