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Browse our anti-AIRE (AIRE) Antibodies

Full name:
anti-Autoimmune Regulator Antibodies (AIRE)
On www.antibodies-online.com are 159 Autoimmune Regulator (AIRE) Antibodies from 27 different suppliers available. Additionally we are shipping AIRE Kits (36) and AIRE Proteins (3) and many more products for this protein. A total of 206 AIRE products are currently listed.
Synonyms:
AIRE1, APECED, APS1, APSI, PGA1
list all antibodies Gene Name GeneID UniProt
AIRE 326 O43918
AIRE 294328  
AIRE 11634 Q9Z0E3

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anti-Human AIRE Antibodies:

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Top referenced anti-AIRE Antibodies

  1. Human Polyclonal AIRE Primary Antibody for IHC, ELISA - ABIN185643 : Niki, Oshikawa, Mouri, Hirota, Matsushima, Yano, Han, Bando, Izumi, Matsumoto, Nakayama, Kuroda, Matsumoto: Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. in The Journal of clinical investigation 2006 (PubMed)
    Show all 3 references for ABIN185643

  2. Cow (Bovine) Polyclonal AIRE Primary Antibody for IHC, WB - ABIN2779777 : Ilmarinen, Kangas, Kytömaa, Eskelin, Saharinen, Seeler, Tanhuanpää, Chan, Slattery, Alakurtti, Palvimo, Ulmanen: Functional interaction of AIRE with PIAS1 in transcriptional regulation. in Molecular immunology 2008 (PubMed)
    Show all 2 references for ABIN2779777

  3. Human Polyclonal AIRE Primary Antibody for IF, WB - ABIN655031 : Conteduca, Ferrera, Pastorino, Fenoglio, Negrini, Sormani, Indiveri, Scarrà, Filaci: The role of AIRE polymorphisms in melanoma. in Clinical immunology (Orlando, Fla.) 2010 (PubMed)

  4. Human Polyclonal AIRE Primary Antibody for IF, ELISA - ABIN1533513 : Hattori, Fujiyama, Taylor, Watanabe, Yada, Park, Toyoda, Ishii, Totoki, Choi, Groner, Soeda, Ohki, Takagi, Sakaki, Taudien, Blechschmidt, Polley, Menzel, Delabar, Kumpf, Lehmann, Patterson, Reichwald et al.: The DNA sequence of human chromosome 21. ... in Nature 2000 (PubMed)

  5. Cow (Bovine) Polyclonal AIRE Primary Antibody for WB - ABIN2779775 : Akiyoshi, Hatakeyama, Pitkänen, Mouri, Doucas, Kudoh, Tsurugaya, Uchida, Matsushima, Oshikawa, Nakayama, Shimizu, Peterson, Matsumoto: Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against AIRE Interaction Partners

Human Autoimmune Regulator (AIRE) interaction partners

  1. the presence of AIRE can trigger molecular events leading to an altered chromatin landscape and the enhanced transcription of low-expressed genes

  2. These data are the first to identify AIRE expression in breast cancer and an association with prognosis.

  3. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3 (show FBXO3 Antibodies)) E3 ubiquitin ligase (show MUL1 Antibodies). In turn, this SCF (show KITLG Antibodies)(FBXO3 (show FBXO3 Antibodies)) (SKP1 (show SKP1 Antibodies)-CUL1 (show CUL1 Antibodies)-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb (show CDK9 Antibodies)), and potentiates its transcriptional activity.

  4. this paper shows that genetic polymorphisms in AIRE do not contribute to the Graves' disease in Spain

  5. This study supports the notion that AIRE mutation could specifically affect human insulin (show INS Antibodies) gene expression in thymic epithelial cells through INS (show INS Antibodies)-VNTR and subsequently induce either insulin (show INS Antibodies) tolerance or autoimmunity.

  6. androgen control of an intrathymic Aire-mediated tolerance mechanism contributes to gender differences in autoimmunity.

  7. results indicate that in females, estrogen induces epigenetic changes in the AIRE gene, leading to reduced AIRE expression under a threshold that increases female susceptibility to autoimmune diseases.

  8. The rs2075876 and rs760426 loci of the AIRE gene are associated with increased risk for rheumatoid arthritis among ethnic Han Chinese from ShaanXi.

  9. The novel mutation of c.622G>T (p.G208W) in AIRE gene is associated autoimmune polyendocrinopathy syndrome type I.

  10. AIRE-655GAIRE-230T haplotype could dramatically alter AIRE transcription.

Mouse (Murine) Autoimmune Regulator (AIRE) interaction partners

  1. this study shows that Aire and some of its partners, notably those implicated in the DNA-damage response, preferentially localize to and activate long chromatin stretches that are overloaded with transcriptional regulators, known as super-enhancers

  2. Results indicated that AIRE influenced gene expression in germ cell 1 spermatogonial (GC1-spg) cells by acting at multiple levels, including transcription, translation, RNA processing, protein transport, protein localization, and protein degradation, thus setting the foundation in understanding the functional role of AIRE in germ cell biology.

  3. this study provides insight into the complex molecular mechanisms that control the medullary thymic epithelial cells-specific expression of Aire

  4. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3 (show FBXO3 Antibodies)) E3 ubiquitin ligase (show MUL1 Antibodies). In turn, this SCF (show KITLG Antibodies)(FBXO3 (show FBXO3 Antibodies)) (SKP1 (show SKP1 Antibodies)-CUL1 (show CUL1 Antibodies)-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb (show CDK9 Antibodies)), and potentiates its transcriptional activity.

  5. we found that Aire up-regulated TLR3 (show TLR3 Antibodies) expression and modulated the downstream cytokine expression and nuclear factor-kappaB (NF-kappaB (show NFKB1 Antibodies)) of the TLR3 (show TLR3 Antibodies) signaling pathway.

  6. Aire-expressing dendritic cells inhibited TCR signaling pathways and decreased quantity of CD4 (show CD4 Antibodies)+IFN-gamma (show IFNG Antibodies)+ autoreactive T cells. Aire plays role in maintenance of peripheral immune tolerance.

  7. Aire may have a role in inducing Th1 (show HAND1 Antibodies) and Th17 differentiation by upregulating cytokine expression in dendritic cells.

  8. androgen control of an intrathymic Aire-mediated tolerance mechanism contributes to gender differences in autoimmunity.

  9. results indicate that in females, estrogen induces epigenetic changes in the AIRE gene, leading to reduced AIRE expression under a threshold that increases female susceptibility to autoimmune diseases.

  10. Our results identify Aire as an important regulator of peripheral T cell homeostasis in gastrointestinal tissues. Given a suitable trigger the absence of peripheral Aire leads to dysregulated T cell proliferation and disease.

AIRE Antigen Profile

Antigen Summary

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

Alternative names and synonyms associated with AIRE

  • autoimmune regulator (AaeL_AAEL013794) antibody
  • autoimmune regulator (CpipJ_CPIJ001208) antibody
  • autoimmune regulator (CpipJ_CPIJ001209) antibody
  • autoimmune regulator (AIRE) antibody
  • autoimmune regulator (Aire) antibody
  • autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) (Aire) antibody
  • autoimmune regulator-like (LOC100621659) antibody
  • AIRE1 antibody
  • APECED antibody
  • APS1 antibody
  • APSI antibody
  • PGA1 antibody

Protein level used designations for AIRE

autoimmune regulator , autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein , autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) , APECED protein homolog , autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog , autoimmune regulator AIRE1a

GENE ID SPECIES
5578645 Aedes aegypti
6032239 Culex quinquefasciatus
6032240 Culex quinquefasciatus
326 Homo sapiens
784775 Bos taurus
294328 Rattus norvegicus
487796 Canis lupus familiaris
100729880 Cavia porcellus
429666 Gallus gallus
101102698 Ovis aries
11634 Mus musculus
100621659 Sus scrofa
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