Browse our CHD8 (CHD8) ELISA Kits

Full name:
Chromodomain Helicase DNA Binding Protein 8 ELISA Kits (CHD8)
On are 0 Chromodomain Helicase DNA Binding Protein 8 (CHD8) ELISA Kits from different suppliers available. Additionally we are shipping CHD8 Antibodies (28) and and many more products for this protein. A total of 30 CHD8 products are currently listed.
5830451P18Rik, AU015341, AUTS18, CHD-8, Chd8, Duplin, fi45h08, HELSNF1, mKIAA1564, si:ch211-10e2.6, wu:fi45h08
list all ELISA KIts Gene Name GeneID UniProt
Human CHD8 CHD8 57680 Q9HCK8
Mouse CHD8 CHD8 67772 Q09XV5
Rat CHD8 CHD8 65027 Q9JIX5

Show all synonyms

More ELISA Kits for CHD8 Interaction Partners

Human Chromodomain Helicase DNA Binding Protein 8 (CHD8) interaction partners

  1. Data suggest that CHD6 (show CHD6 ELISA Kits) and CHD7 (show CHD7 ELISA Kits) both bind with high affinity to short linker DNA, whereas CHD8 requires longer DNA for binding; thus, CHD8 slides nucleosomes into positions with more flanking linker DNA than CHD7 (show CHD7 ELISA Kits); CHD6 (show CHD6 ELISA Kits) disrupts nucleosomes in a distinct non-sliding manner.

  2. present observation and published data suggest that phenotype present in patients with duplication of 14q11.2 region, encompassing the SUPT16H (show SUPT16H ELISA Kits) and CHD8 genes, resemble in some extend features described in cases carrying microdeletion of that genomic region

  3. Review of 16 other CHD8 mutation cases suggests that clinical features and their severity vary considerably across individuals; however, these data support a CHD8 mutation syndrome, further highlighting the importance of genomic medicine to guide clinical assessment and treatment

  4. Our clinical case supports the hypothesis that CHD8 may play a central role in neuronal cell development and Autism spectrum disorders risk

  5. Study provides evidence that links the CHD8 chromatin remodeler to the cancer maintenance functions of BRD4 (show BRD4 ELISA Kits) and NSD3 (show WHSC1L1 ELISA Kits).

  6. Taken together our data demonstrate that CHD8 is involved in late stages of progesterone receptor (show PGR ELISA Kits) enhancers activation.

  7. Loss of CHD8 contributes to autism spectrum disorder by perturbing an ancient gene regulatory network during human brain development.

  8. CHD8 insufficiency results in altered gene expression of coding genes and noncoding RNAs. The changes among protein-coding genes involved genes that are enriched in neuronal development and in previously identified autism candidate genes.

  9. In the first detailed analysis in cancer, a marked loss of CHD8 expression and increased BORIS (show CTCFL ELISA Kits)/CTCF (show CTCF ELISA Kits) ratio indicate frequent disruption of CTCF (show CTCF ELISA Kits) and its effector genes in PCa (show FLVCR1 ELISA Kits).

  10. Recurrent approximately 100 Kb microdeletion in the chromosomal region 14q11.2, involving CHD8 gene, is associated with autism and macrocephaly.

Mouse (Murine) Chromodomain Helicase DNA Binding Protein 8 (CHD8) interaction partners

  1. identified a co-expression module with peak expression in early brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by Chd8

  2. these roles of Chd8 and the dynamics of Chd8 expression during development help negotiate the fine balance between neural progenitor proliferation and differentiation

  3. find altered synaptic physiology in medium spiny neurons of the nucleus accumbens. Perturbation of Chd8 in adult mice recapitulates improved acquired motor learning behavior found in Chd8(+/-) animals, suggesting a role for CHD8 in adult striatal circuits. These results support a mechanism linking chromatin modification to striatal dysfunction and the molecular pathology of ASD (show GUSB ELISA Kits).

  4. results are thus consistent with the notion that CHD8 haploinsufficiency is a highly penetrant risk factor for autism spectrum disorder, with disease pathogenesis probably resulting from a delay in neurodevelopment

  5. The chromatin regulator CHD8 is a context-dependent mediator of cell survival in murine hematopoietic malignancies.

  6. Chd8 promotes the association of beta-catenin (show CTNNB1 ELISA Kits) and histone H1 (show H1F0 ELISA Kits), with formation of the trimeric complex on chromatin being required for inhibition of beta-catenin (show CTNNB1 ELISA Kits)-dependent transactivation.

  7. These data suggest that CHD8 plays a dual role in smooth muscle cells modulating SRF activity toward differentiation genes and promoting cell survival through interactions with both SRF and CTCF (show CTCF ELISA Kits) to regulate expression of Birc5 (show BIRC5 ELISA Kits) and CARD10 (show CARD10 ELISA Kits).

  8. These observations reveal a mode of p53 (show TP53 ELISA Kits) regulation mediated by CHD8, which may set a threshold for induction of apoptosis during early embryogenesis by counteracting p53 (show TP53 ELISA Kits) function through recruitment of histone H1 (show H1F0 ELISA Kits).

Zebrafish Chromodomain Helicase DNA Binding Protein 8 (CHD8) interaction partners

  1. CHD8 precipitates a network of gene-expression changes involved in neurodevelopmental pathways in which many autism spectrum disorder-associated genes may converge on shared mechanisms of pathogenesis

CHD8 Antigen Profile

Antigen Summary

This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CHD8

  • chromodomain helicase DNA binding protein 8 (CHD8) Elisa Kit
  • chromodomain helicase DNA binding protein 8 (Chd8) Elisa Kit
  • chromodomain helicase DNA binding protein 8 (chd8) Elisa Kit
  • 5830451P18Rik Elisa Kit
  • AU015341 Elisa Kit
  • AUTS18 Elisa Kit
  • CHD-8 Elisa Kit
  • Chd8 Elisa Kit
  • Duplin Elisa Kit
  • fi45h08 Elisa Kit
  • HELSNF1 Elisa Kit
  • mKIAA1564 Elisa Kit
  • si:ch211-10e2.6 Elisa Kit
  • wu:fi45h08 Elisa Kit

Protein level used designations for CHD8

chromodomain helicase DNA binding protein 8 , chromodomain-helicase-DNA-binding protein 8 , ATP-dependent helicase CHD8 , chromodomain-helicase-DNA-binding protein 8-like , axis duplication inhibitor , duplin , helicase with SNF2 domain 1 , CHD-8 , beta-catenin binding protein , chromodomain helicase DNA binding protein family

475401 Canis lupus familiaris
507111 Bos taurus
739837 Pan troglodytes
100023377 Monodelphis domestica
100059337 Equus caballus
100192376 Xenopus (Silurana) tropicalis
100406255 Callithrix jacchus
100439513 Pongo abelii
100464946 Ailuropoda melanoleuca
100595705 Nomascus leucogenys
57680 Homo sapiens
67772 Mus musculus
65027 Rattus norvegicus
568214 Danio rerio
Did you look for something else?