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Provide molecular insight into how DHX30 dysfunction might cause a neurodevelopmental disorder.
Here, we provide evidence that overexpression of an RNA helicase (show DDX46 ELISA Kits) named DHX30 enhances HIV-1 gene expression, but leads to the generation of viruses that package significantly low levels of viral RNA and exhibit severely decreased infectivity.
Identifies DHX30 as a nucleoid protein.
An improved gene trap method "trapped" a helG gene expressed in mouse ES cells. The helG product shared a high level of homology with the DExH RNA helicase family (show ASCC3 ELISA Kits). It is required for differentiation during embryogenesis.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The family member encoded by this gene is a mitochondrial nucleoid protein that associates with mitochondrial DNA. It has also been identified as a component of a transcriptional repressor complex that functions in retinal development, and it is required to optimize the function of the zinc-finger antiviral protein. Alternatively spliced transcript variants have been found for this gene.
DEAH (Asp-Glu-Ala-His) box polypeptide 30
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 30
, DEAH box protein 30
, putative ATP-dependent RNA helicase DHX30
, retina co-repressor