Browse our anti-HELLS (HELLS) Antibodies

Full name:
anti-Helicase, Lymphoid-Specific Antibodies (HELLS)
On are 60 Helicase, Lymphoid-Specific (HELLS) Antibodies from 13 different suppliers available. Additionally we are shipping HELLS Proteins (4) and many more products for this protein. A total of 72 HELLS products are currently listed.
AI323785, cb65, E130115I21Rik, HELLS, im:6911667, lsh, Lysh, nbla10143, PASG, sb:cb65, sb:cb749, smarca6, Tbc1d12, YFK8
list all antibodies Gene Name GeneID UniProt
HELLS 15201 Q60848
HELLS 294071  

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Most Popular Reactivities for anti-HELLS (HELLS) Antibodies

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anti-Mouse (Murine) HELLS Antibodies:

anti-Rat (Rattus) HELLS Antibodies:

anti-Human HELLS Antibodies:

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Top referenced anti-HELLS Antibodies

  1. Human Monoclonal HELLS Primary Antibody for WB - ABIN394178 : Zhou, Han, Li, Tong: Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts. in Nucleic acids research 2009 (PubMed)
    Show all 5 references for 394178

  2. Cow (Bovine) Polyclonal HELLS Primary Antibody for WB - ABIN2775238 : Myant, Stancheva: LSH cooperates with DNA methyltransferases to repress transcription. in Molecular and cellular biology 2007 (PubMed)

More Antibodies against HELLS Interaction Partners

Zebrafish Helicase, Lymphoid-Specific (HELLS) interaction partners

  1. Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1 (show DNMT1 Antibodies).

Mouse (Murine) Helicase, Lymphoid-Specific (HELLS) interaction partners

  1. fibroblasts derived from chromatin remodeling ATPase (show DNAH8 Antibodies) LSH (HELLS)-null mouse embryos, which lack DNA methylation from centromeric repeats, transposons and a number of gene promoters, are capable of reestablishing DNA methylation and silencing of misregulated genes upon re-expression of LSH.

  2. Data suggest that HELLS controls cytosine methylation in a nuclear compartment that is in part defined by lamin B1 (show LMNB1 Antibodies) attachment regions.

  3. histone H3 (show HIST3H3 Antibodies) lysine 4 methylation modification was assessed in murine embryonic fibroblasts (MEFs) derived from the DNA methylation mutant Lsh(-/-) mice.

  4. These results indicate that in the absence of HELLS, proliferation of spermatogonia is reduced and germ cell differentiation arrested at the midpachytene stage, implicating an essential role for HELLS during male meiosis.

  5. LSH is essential for developmentally programmed de novo DNA methylation at the promoters of protein coding genes and recruitment of G9a (show EHMT2 Antibodies)/GLP (show GOLGA6A Antibodies) complex to a subset of genomic loci.

  6. Data show that hypomethylation in Lsh-/- cells is associated with efficient transcriptional elongation and splicing.

  7. model in which Lsh is recruited by intact heterochromatin structure and then assists in maintaining heterochromatin organization by establishing CpG methylation patterns

  8. PASG mutant mice display signs of growth retardation and premature aging, including low birth weight, failure to thrive, graying and loss of hair, reduced skin fat deposition, osteoporosis, kyphosis, cachexia, and premature death.

  9. Lsh has a critical and previously unidentified role in epigenetic gene silencing and maintenance of genomic stability during female meiosis.

  10. Lsh is part of a physiological feedback loop that reinforces DNA methylation and silencing of polycomb (show CBX2 Antibodies) repressive complex targets

Human Helicase, Lymphoid-Specific (HELLS) interaction partners

  1. LSH promoted cancer progression in part by regulating expression of fumarate hydratase (FH (show FH Antibodies)).

  2. Mutations in HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome type 4.

  3. Mutations of HELLS gene is associated with stomach and colorectal cancers.

  4. Upregulation of HELLS and UHRF1 (show UHRF1 Antibodies) is essential for the tumor phenotype. Also, these epigenetic regulators are important for the regulation of SYK (show SYK Antibodies).

  5. just as E2F3, HELLS is overexpressed in human tumours including prostate cancer, indicating that either factor may contribute to the malignant progression of tumours

  6. E2F1 (show E2F1 Antibodies) plays a crucial role in transcriptional control of the human Lsh gene and the decrease of Lsh expression in senescent cells is related to the repression of E2F1 (show E2F1 Antibodies)

  7. Data provide strong evidence that CEP55 (show CEP55 Antibodies) and HELLS may be used in conjunction with FOXM1 (show FOXM1 Antibodies) as a biomarker set for early cancer detection and indicators of malignant conversion and progression.

  8. LSH serves as a recruiting factor for DNA methyltransferases and histone deacetylases to establish transcriptionally repressive chromatin which is perhaps further stabilized by DNA methylation at targeted loci

  9. These results suggest differences in cellular consequences of hypomethylation mediated by PASG during development compared to that in somatic cells.

  10. Lsh overexpression delays cell senescence by silencing p16(INK4a (show CDKN2A Antibodies)) in human fibroblasts.

Xenopus laevis Helicase, Lymphoid-Specific (HELLS) interaction partners

  1. Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1 (show DNMT1 Antibodies).

HELLS Antigen Profile

Antigen Summary

This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Alternative names and synonyms associated with HELLS

  • helicase, lymphoid-specific (HELLS) antibody
  • helicase, lymphoid-specific (hells) antibody
  • helicase, lymphoid specific (Hells) antibody
  • AI323785 antibody
  • cb65 antibody
  • E130115I21Rik antibody
  • HELLS antibody
  • im:6911667 antibody
  • lsh antibody
  • Lysh antibody
  • nbla10143 antibody
  • PASG antibody
  • sb:cb65 antibody
  • sb:cb749 antibody
  • smarca6 antibody
  • Tbc1d12 antibody
  • YFK8 antibody

Protein level used designations for HELLS

helicase, lymphoid-specific , helicase, lymphoid specific , lymphoid-specific helicase-like , lymphocyte-specific helicase , proliferation-associated SNF2-like protein , TBC1D12: TBC1 domain family, member 12 , SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6 , SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6 , lymphoid-specific helicase

423750 Gallus gallus
450624 Pan troglodytes
553328 Danio rerio
701598 Macaca mulatta
100061642 Equus caballus
100216265 Xenopus (Silurana) tropicalis
100387530 Callithrix jacchus
100544292 Meleagris gallopavo
100566701 Anolis carolinensis
100601099 Nomascus leucogenys
15201 Mus musculus
294071 Rattus norvegicus
3070 Homo sapiens
446222 Xenopus laevis
486809 Canis lupus familiaris
100154547 Sus scrofa
540933 Bos taurus
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