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Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1 (show DNMT1 Proteins).
fibroblasts derived from chromatin remodeling ATPase LSH (HELLS)-null mouse embryos, which lack DNA methylation from centromeric repeats, transposons and a number of gene promoters, are capable of reestablishing DNA methylation and silencing of misregulated genes upon re-expression of LSH.
Data suggest that HELLS controls cytosine methylation in a nuclear compartment that is in part defined by lamin B1 (show LMNB1 Proteins) attachment regions.
histone H3 (show HIST3H3 Proteins) lysine 4 methylation modification was assessed in murine embryonic fibroblasts (MEFs) derived from the DNA methylation mutant Lsh(-/-) mice.
These results indicate that in the absence of HELLS, proliferation of spermatogonia is reduced and germ cell differentiation arrested at the midpachytene stage, implicating an essential role for HELLS during male meiosis.
LSH is essential for developmentally programmed de novo DNA methylation at the promoters of protein coding genes and recruitment of G9a/GLP complex to a subset of genomic loci.
Data show that hypomethylation in Lsh-/- cells is associated with efficient transcriptional elongation and splicing.
model in which Lsh is recruited by intact heterochromatin structure and then assists in maintaining heterochromatin organization by establishing CpG methylation patterns
PASG mutant mice display signs of growth retardation and premature aging, including low birth weight, failure to thrive, graying and loss of hair, reduced skin fat deposition, osteoporosis, kyphosis, cachexia, and premature death.
Lsh has a critical and previously unidentified role in epigenetic gene silencing and maintenance of genomic stability during female meiosis.
Lsh is part of a physiological feedback loop that reinforces DNA methylation and silencing of polycomb (show CBX2 Proteins) repressive complex targets
LSH promoted cancer progression in part by regulating expression of fumarate hydratase (FH (show FH Proteins)).
Mutations in HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome type 4.
Mutations of HELLS gene is associated with stomach and colorectal cancers.
Upregulation of HELLS and UHRF1 (show UHRF1 Proteins) is essential for the tumor phenotype. Also, these epigenetic regulators are important for the regulation of SYK (show SYK Proteins).
just as E2F3, HELLS is overexpressed in human tumours including prostate cancer, indicating that either factor may contribute to the malignant progression of tumours
E2F1 (show E2F1 Proteins) plays a crucial role in transcriptional control of the human Lsh gene and the decrease of Lsh expression in senescent cells is related to the repression of E2F1 (show E2F1 Proteins)
Data provide strong evidence that CEP55 (show CEP55 Proteins) and HELLS may be used in conjunction with FOXM1 (show FOXM1 Proteins) as a biomarker set for early cancer detection and indicators of malignant conversion and progression.
LSH serves as a recruiting factor for DNA methyltransferases and histone deacetylases to establish transcriptionally repressive chromatin which is perhaps further stabilized by DNA methylation at targeted loci
These results suggest differences in cellular consequences of hypomethylation mediated by PASG during development compared to that in somatic cells.
Lsh overexpression delays cell senescence by silencing p16(INK4a) in human fibroblasts.
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
, helicase, lymphoid specific
, lymphoid-specific helicase-like
, lymphocyte-specific helicase
, proliferation-associated SNF2-like protein
, TBC1D12: TBC1 domain family, member 12
, SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
, SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6
, lymphoid-specific helicase