Browse our anti-HIRA (HIRA) Antibodies

Full name:
anti-HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) Antibodies (HIRA)
On www.antibodies-online.com are 63 HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) Antibodies from 16 different suppliers available. Additionally we are shipping HIRA Proteins (5) and many more products for this protein. A total of 74 HIRA products are currently listed.
Synonyms:
AA138857, D16Ertd95e, dgcr1, HIRA, hira-A, homolog of histone chaperone HIRA, N28177, si:ch211-188g24.3, tup1, tuple1, wu:fb97b07, wu:fi43b08
list all antibodies Gene Name GeneID UniProt
HIRA 363849  
HIRA 15260 Q61666
HIRA 7290 P54198

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Top referenced anti-HIRA Antibodies

  1. Yeast (Saccharomyces cerevisiae) Monoclonal HIRA Primary Antibody for WB - ABIN264454 : Bone, Roth: Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation. in The Journal of biological chemistry 2001 (PubMed)
    Show all 3 references for 264454

  2. Human Polyclonal HIRA Primary Antibody for IF, WB - ABIN521162 : Jiang, Nguyen, Cao, Chang, Reddel: HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a. in PLoS ONE 2011 (PubMed)

  3. Human Polyclonal HIRA Primary Antibody for WB - ABIN390223 : Zhang, Chen, Adams: Molecular dissection of formation of senescence-associated heterochromatin foci. in Molecular and cellular biology 2007 (PubMed)

  4. Human Monoclonal HIRA Primary Antibody for ICC, IF - ABIN4889661 : Inoue, Zhang: Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes. in Nature structural & molecular biology 2014 (PubMed)

More Antibodies against HIRA Interaction Partners

Mouse (Murine) HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. transcriptional regulation by HIRA is crucial for cardiomyocyte homeostasis.

  2. Data show that Hira is important to mediates Histone H3 (show HIST3H3 Antibodies)/H4 replacement during mouse oogenesis which is required for normal 5mC deposition in oocytes. Its loss results in chromatin abnormalities and extensive oocyte loss.

  3. HIRA is not only critical for beta-globin (show HBB Antibodies) expression but is also required for activation of the erythropoietic regulators EKLF (show KLF1 Antibodies) and GATA binding protein 1 (GATA1).

  4. Hira-mediated H3.3 incorporation is essential for parental genome reprogramming and reveal an unexpected role for rRNA transcription in the mouse zygote

  5. WHSC1 (show WHSC1 Antibodies) links transcription elongation to HIRA-mediated histone H3.3 (show H3F3A Antibodies) deposition.

  6. HIRA interacts with H3.3/H4 in the absence of Daxx (show DAXX Antibodies).

  7. HIRA is an essential factor for muscle development by establishing MyoD (show MYOD1 Antibodies) activation in myotubes.

  8. Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality

Human HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. PHB (show PHB Antibodies) has an unexpected nuclear role in human embryonic stem cells that is required for self-renewal and that it acts with HIRA in chromatin organization to link epigenetic organization to a metabolic circuit.

  2. The abnormal lower expression of the HIRA gene in the myocardium may participate in the pathogenesis of Tetralogy of Fallot.

  3. These results support a model in which OGT (show OGT Antibodies) modifies HIRA to regulate HIRA-H3.3 complex formation and H3.3 nucleosome assembly and reveal the mechanism by which OGT (show OGT Antibodies) functions in cellular senescence.

  4. HIRA controls a specialized, dynamic H4K16ac-decorated chromatin landscape in senescent cells and enforces tumor suppression.

  5. Mechanistic studies reveal that HIRA accumulates at sites of UVC irradiation upon detection of DNA damage prior to repair and deposits newly synthesized H3.3 histones. This local action of HIRA depends on ubiquitylation events associated with damage recognition.

  6. HIRA is required for deposition of histone H3.3 (show H3F3A Antibodies) at its binding sites.

  7. NHRD domain of UBN1 (show UBN1 Antibodies) as being an essential region for HIRA interaction and chromatin organization by the HUCA complex

  8. HIRA plays a unique, ASF1a (show ASF1A Antibodies)-independent role, which is required for the localization of HP1 (show DEFA1 Antibodies)

  9. Data show that, like HIRA, UBN1 (show UBN1 Antibodies), and ASF1a (show ASF1A Antibodies), CABIN1 (show CABIN1 Antibodies) is involved in heterochromatinization of the genome of senescent human cells.

  10. phosphorylation of histone H4 Ser 47 catalyzed by the PAK2 kinase, promotes nucleosome assembly of H3.3-H4 and inhibits nucleosome assembly of H3.1-H4 by increasing the binding affinity of HIRA to H3.3-H4 and reducing association of CAF-1 with H3.1-H4

Xenopus laevis HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. Downregulation of the H3.3 histone chaperone HIRA similarly impairs late gastrulation.

Arabidopsis thaliana HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. Loss of HIRA reduces extractable histone H3 protein levels and decreases nucleosome occupancy at both actively transcribed genes and heterochromatic regions.

HIRA Antigen Profile

Antigen Summary

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Alternative names and synonyms associated with HIRA

  • HIR histone cell cycle regulation defective homolog A (S. cerevisiae) (HIRA) antibody
  • HIR histone cell cycle regulation defective homolog A (S. cerevisiae) (hira) antibody
  • HIR histone cell cycle regulation defective homolog A (S. cerevisiae) (Hira) antibody
  • HIRA (LOC732736) antibody
  • histone cell cycle regulation defective homolog A (S. cerevisiae) (Hira) antibody
  • histone cell cycle regulator (HIRA) antibody
  • histone cell cycle regulator (hira) antibody
  • protein HIRA (HIRA) antibody
  • Tuple1/HirA (hira) antibody
  • AA138857 antibody
  • D16Ertd95e antibody
  • dgcr1 antibody
  • HIRA antibody
  • hira-A antibody
  • homolog of histone chaperone HIRA antibody
  • N28177 antibody
  • si:ch211-188g24.3 antibody
  • tup1 antibody
  • tuple1 antibody
  • wu:fb97b07 antibody
  • wu:fi43b08 antibody

Protein level used designations for HIRA

HIR histone cell cycle regulation defective homolog A (S. cerevisiae) , fb97b07 , HIR histone cell cycle regulation defective homolog A-like , protein HIRA-like , histone cell cycle regulation defective homolog A , protein HIRA , TUP1-like enhancer of split protein 1 , cHIRA , histone regulator protein , TUP1-like enhancer of split gene 1 , DiGeorge critical region gene 1 , HIR histone cell cycle regulation defective homolog A

GENE ID SPECIES
470138 Pan troglodytes
568076 Danio rerio
100052845 Equus caballus
100352472 Oryctolagus cuniculus
100368021 Saccoglossus kowalevskii
100407742 Callithrix jacchus
100450459 Pongo abelii
100467668 Ailuropoda melanoleuca
100581135 Nomascus leucogenys
486424 Canis lupus familiaris
100153131 Sus scrofa
511514 Bos taurus
363849 Rattus norvegicus
374074 Gallus gallus
732736 Zea mays
15260 Mus musculus
7290 Homo sapiens
394341 Xenopus laevis
823578 Arabidopsis thaliana
446054 Takifugu rubripes
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