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HMGN1 and HMGN 2 (show HMGN2 ELISA Kits) remodel core and linker histone tail domains within chromatin.
RNA-seq evidence of biallelic expression of HMGN1 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of HMGN1 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (show WRB ELISA Kits) differentially methylated region (DMR (show WDR20 ELISA Kits)) in disomic controls or trisomy (Down syndrome) individuals.
HMGN1 can serve as a useful clinical parameter for evaluating disease progression and predicting the outcomes for early-stage patients with non-small cell lung cancer .
nucleosome binding protein HMGN1 as a new PCNA (show PCNA ELISA Kits)-interacting protein that enhances the binding of PCNA (show PCNA ELISA Kits) to chromatin
extracellular HMGN1 acts as a novel alarmin critical for LPS (show IRF6 ELISA Kits)-induced development of innate and adaptive immune responses.
HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) in mouse and human, and affects the behavior of mice
HMGN1 is not randomly distributed throughout the genome. Instead, the protein preferentially localizes to DNase I (show DNASE1 ELISA Kits) hypersensitive (HS) sites, promoters, functional enhancers, and transcription factor binding sites.
Results show that four serine residues, i.e., Ser6, Ser85, Ser88, and Ser98, can be phosphorylated in high mobility group (show SSRP1 ELISA Kits) N1 (HMGN1).
HMGN1 optimizes the cellular response to ionizing radiation and to other tumorigenic events; therefore, loss of this protein increases the tumor burden in mice.
SWI (show SMARCA1 ELISA Kits)/SNF (show SNRPA ELISA Kits) functions independently of HMGN1
Suggest Hmgn1/Cebpb (show CEBPB ELISA Kits) signaling may play an important role during mouse decidualization.
our findings show that HMGN1 contributes to antitumor immunity and it may offer an effective adjuvant to heighten responses to cancer vaccines.
in mice, loss of HMGN1 leads to transcription changes that accelerate the progression of DEN-induced hepatocarcinogenesis, without affecting the type of tumors or the final total tumor burden of these mice.
HMGN1 is a nucleosome remodeling protein encoded on chromosome 21q22 that suppresses H3K27me3 and promotes both B cell proliferation in vitro and B-ALL in vivo
HMGN1 binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I (show DNASE1 ELISA Kits) hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and neural progenitors.
Phenotypic analysis of Hmgn1(tm1/tm1 (show TPM2 ELISA Kits)), Hmgn3 (show HMGN3 ELISA Kits)(tm1/tm1 (show TPM2 ELISA Kits)), and Hmgn5 (show HMGN5 ELISA Kits)(tm1/tm1 (show TPM2 ELISA Kits)) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities.
a regulatory role for HMGN1 in PARP-1 (show PARP1 ELISA Kits) activation.
extracellular HMGN1 acts as a novel alarmin critical for LPS (show TLR4 ELISA Kits)-induced development of innate and adaptive immune responses.
Regulation of Hmgn1 and Fgf18 (show FGF18 ELISA Kits) at the digit-interdigit junction suggests retinoic acid controls tissue remodeling as well as apoptosis.
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes.
high mobility group nucleosome-binding domain-containing protein 1
, high-mobility group (nonhistone chromosomal) protein 14
, high-mobility group nucleosome binding 1
, high-mobility group nucleosome binding domain 1
, non-histone chromosomal protein HMG-14
, nonhistone chromosomal protein HMG-14
, high-mobility group nucleosome binding domain 1 b
, high mobility group protein 14
, high-mobility group nucleosome-binding domain-containing protein 1
, HMG-14 protein
, non-histone chromosomal protein HMG-14B